Gene Review:
Pax4 - paired box 4
Mus musculus
Synonyms:
Paired box protein Pax-4, Pax-4
- Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation. Tang, D.Q., Cao, L.Z., Chou, W., Shun, L., Farag, C., Atkinson, M.A., Li, S.W., Chang, L.J., Yang, L.J. Lab. Invest. (2006)
- Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. St-Onge, L., Sosa-Pineda, B., Chowdhury, K., Mansouri, A., Gruss, P. Nature (1997)
- The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Sosa-Pineda, B., Chowdhury, K., Torres, M., Oliver, G., Gruss, P. Nature (1997)
- Opposing actions of Arx and Pax4 in endocrine pancreas development. Collombat, P., Mansouri, A., Hecksher-Sorensen, J., Serup, P., Krull, J., Gradwohl, G., Gruss, P. Genes Dev. (2003)
- Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Prado, C.L., Pugh-Bernard, A.E., Elghazi, L., Sosa-Pineda, B., Sussel, L. Proc. Natl. Acad. Sci. U.S.A. (2004)
- The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Wang, J., Elghazi, L., Parker, S.E., Kizilocak, H., Asano, M., Sussel, L., Sosa-Pineda, B. Dev. Biol. (2004)
- Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Blyszczuk, P., Czyz, J., Kania, G., Wagner, M., Roll, U., St-Onge, L., Wobus, A.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas. Fujitani, Y., Kajimoto, Y., Yasuda, T., Matsuoka, T.A., Kaneto, H., Umayahara, Y., Fujita, N., Watada, H., Miyazaki, J.I., Yamasaki, Y., Hori, M. Mol. Cell. Biol. (1999)
- Cloning of the mouse Pax4 gene promoter and identification of a pancreatic beta cell specific enhancer. Xu, W., Murphy, L.J. Mol. Cell. Endocrinol. (2000)
- Pax 4 and 6 regulate gastrointestinal endocrine cell development. Larsson, L.I., St-Onge, L., Hougaard, D.M., Sosa-Pineda, B., Gruss, P. Mech. Dev. (1998)
- DNA binding and transactivating properties of the paired and homeobox protein Pax4. Kalousová, A., Benes, V., Paces, J., Paces, V., Kozmik, Z. Biochem. Biophys. Res. Commun. (1999)
- High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells. Cao, L.Z., Tang, D.Q., Horb, M.E., Li, S.W., Yang, L.J. Diabetes (2004)
- The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6. Ritz-Laser, B., Estreicher, A., Gauthier, B.R., Mamin, A., Edlund, H., Philippe, J. Diabetologia (2002)
- Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4. Smith, S.B., Gasa, R., Watada, H., Wang, J., Griffen, S.C., German, M.S. J. Biol. Chem. (2003)
- Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells. Blyszczuk, P., Asbrand, C., Rozzo, A., Kania, G., St-Onge, L., Rupnik, M., Wobus, A.M. Int. J. Dev. Biol. (2004)
- Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Smith, S.B., Ee, H.C., Conners, J.R., German, M.S. Mol. Cell. Biol. (1999)
- Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4. Matsushita, T., Yamaoka, T., Otsuka, S., Moritani, M., Matsumoto, T., Itakura, M. Biochem. Biophys. Res. Commun. (1998)