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Gene Review

Ptgir  -  prostaglandin I receptor (IP)

Mus musculus

Synonyms: IP, PGI receptor, PGI2, PGI2 receptor, Prostacyclin receptor, ...
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Disease relevance of Ptgir


High impact information on Ptgir


Biological context of Ptgir


Anatomical context of Ptgir


Associations of Ptgir with chemical compounds


Physical interactions of Ptgir


Other interactions of Ptgir

  • Ptgdr mapped to proximal Chr 14, Ptgfr mapped to distal Chr 3, Ptgerepl mapped to middle Chr 8, and Ptgir mapped to proximal Chr 7 [22].

Analytical, diagnostic and therapeutic context of Ptgir


  1. Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: a model with prostanoid-related cachexia. Wang, W., Andersson, M., Lõnnroth, C., Svanberg, E., Lundholm, K. Int. J. Cancer (2005) [Pubmed]
  2. Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor. Hara, A., Yuhki, K., Fujino, T., Yamada, T., Takayama, K., Kuriyama, S., Takahata, O., Karibe, H., Okada, Y., Xiao, C.Y., Ma, H., Narumiya, S., Ushikubi, F. Circulation (2005) [Pubmed]
  3. Translocation of alpha subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells. Negishi, M., Hashimoto, H., Ichikawa, A. J. Biol. Chem. (1992) [Pubmed]
  4. Intrinsic prostacyclin contributes to exudation induced by bradykinin or carrageenin: a study on the paw edema induced in IP-receptor-deficient mice. Ueno, A., Naraba, H., Ikeda, Y., Ushikubi, F., Murata, T., Narumiya, S., Oh-ishi, S. Life Sci. (2000) [Pubmed]
  5. Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. Kobayashi, T., Tahara, Y., Matsumoto, M., Iguchi, M., Sano, H., Murayama, T., Arai, H., Oida, H., Yurugi-Kobayashi, T., Yamashita, J.K., Katagiri, H., Majima, M., Yokode, M., Kita, T., Narumiya, S. J. Clin. Invest. (2004) [Pubmed]
  6. Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. Fujino, T., Nakagawa, N., Yuhki, K., Hara, A., Yamada, T., Takayama, K., Kuriyama, S., Hosoki, Y., Takahata, O., Taniguchi, T., Fukuzawa, J., Hasebe, N., Kikuchi, K., Narumiya, S., Ushikubi, F. J. Clin. Invest. (2004) [Pubmed]
  7. Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. Fabre, J.E., Nguyen, M., Athirakul, K., Coggins, K., McNeish, J.D., Austin, S., Parise, L.K., FitzGerald, G.A., Coffman, T.M., Koller, B.H. J. Clin. Invest. (2001) [Pubmed]
  8. Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Hirata, M., Kakizuka, A., Aizawa, M., Ushikubi, F., Narumiya, S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling. Lawler, O.A., Miggin, S.M., Kinsella, B.T. J. Biol. Chem. (2001) [Pubmed]
  10. cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. Namba, T., Oida, H., Sugimoto, Y., Kakizuka, A., Negishi, M., Ichikawa, A., Narumiya, S. J. Biol. Chem. (1994) [Pubmed]
  11. Investigation of the effect of the farnesyl protein transferase inhibitor R115777 on isoprenylation and intracellular signalling by the prostacyclin receptor. O'Meara, S.J., Kinsella, B.T. Br. J. Pharmacol. (2004) [Pubmed]
  12. Two types of prostacyclin receptor coupling to stimulation of adenylate cyclase and phosphatidylinositol hydrolysis in a cultured mast cell line, BNu-2cl3 cells. Oka, M., Negishi, M., Nishigaki, N., Ichikawa, A. Cell. Signal. (1993) [Pubmed]
  13. Novel 1-oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines: Synthesis, selectively analgesic action, and QSAR analysis. Zhao, M., Li, Z., Peng, L., Tang, Y.R., Wang, C., Zhang, Z., Peng, S. Bioorg. Med. Chem. (2007) [Pubmed]
  14. Identification of a prostacyclin receptor coupled to the adenylate cyclase system via a stimulatory GTP-binding protein in mouse mastocytoma P-815 cells. Hashimoto, H., Negishi, M., Ichikawa, A. Prostaglandins (1990) [Pubmed]
  15. PPAR delta functions as a prostacyclin receptor in blastocyst implantation. Lim, H., Dey, S.K. Trends Endocrinol. Metab. (2000) [Pubmed]
  16. Augmentation of allergic inflammation in prostanoid IP receptor deficient mice. Takahashi, Y., Tokuoka, S., Masuda, T., Hirano, Y., Nagao, M., Tanaka, H., Inagaki, N., Narumiya, S., Nagai, H. Br. J. Pharmacol. (2002) [Pubmed]
  17. 7,7-Difluoroprostacyclin derivative, AFP-07, a highly selective and potent agonist for the prostacyclin receptor. Chang, C.S., Negishi, M., Nakano, T., Morizawa, Y., Matsumura, Y., Ichikawa, A. Prostaglandins (1997) [Pubmed]
  18. Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. Minami, T., Okuda-Ashitaka, E., Nishizawa, M., Mori, H., Ito, S. Br. J. Pharmacol. (1997) [Pubmed]
  19. Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. Cheng, H.F., Wang, S.W., Zhang, M.Z., McKanna, J.A., Breyer, R., Harris, R.C. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  20. TEI-3356, a highly selective agonist for the prostaglandin EP3 receptor. Negishi, M., Harazono, A., Sugimoto, Y., Hazato, A., Kurozumi, S., Ichikawa, A. Prostaglandins (1994) [Pubmed]
  21. Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics. Chow, K.B., Wong, Y.H., Wise, H. Br. J. Pharmacol. (2001) [Pubmed]
  22. Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors. Ishikawa, T.O., Tamai, Y., Rochelle, J.M., Hirata, M., Namba, T., Sugimoto, Y., Ichikawa, A., Narumiya, S., Taketo, M.M., Seldin, M.F. Genomics (1996) [Pubmed]
  23. Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis. Honda, T., Segi-Nishida, E., Miyachi, Y., Narumiya, S. J. Exp. Med. (2006) [Pubmed]
  24. In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs. Oida, H., Namba, T., Sugimoto, Y., Ushikubi, F., Ohishi, H., Ichikawa, A., Narumiya, S. Br. J. Pharmacol. (1995) [Pubmed]
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