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Gene Review

Ptgfr  -  prostaglandin F receptor

Mus musculus

Synonyms: AI957154, FP, PGF, PGF receptor, PGF2-alpha receptor, ...
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Disease relevance of Ptgfr


High impact information on Ptgfr


Chemical compound and disease context of Ptgfr

  • Although PGF caused reduced granuloma macrophage Ia expression and O2- production, it did not suppress IL-1 production [3].
  • Prostaglandin F2 alpha (PGF 2 alpha) has a bronchoconstrictive effect on the smooth muscles of the bronchial tree, while a prostaglandin of the E series (PGE) provokes bronchodilatation in bronchial asthma (BA) [8].

Biological context of Ptgfr


Anatomical context of Ptgfr


Associations of Ptgfr with chemical compounds

  • PGF2alpha receptor (FP) is coupled to stimulation of phospholipase C-inositol trisphosphate (IP3) pathway and Ca2+ mobilization [15].
  • Sulprostone and (+)-fluprostenol failed to modulate any of responses tested, suggesting lack of involvement/expression of EP(1), EP(3), and FP receptors in DC activation [16].
  • Control cultures prelabelled with either AA or EPA produced similar amounts of the respective PGF, PGE, and PGD [17].
  • In the freeze-thawed preparations, use of AA as a substrate resulted in significantly more PGF than when EPA was used as the substrate [17].
  • AL-3138 competed for [3H]PGF2alpha binding to FP receptors with a relatively high affinity (IC50high = 312 +/- 95 nM) matching its functional antagonist potency [18].

Regulatory relationships of Ptgfr

  • These results strongly suggest that RA suppresses the phospholipase D activated by PGF2 alpha in osteoblast-like cells and that the effect of RA is exerted at the point between PGF2 alpha receptor and G-protein [19].

Other interactions of Ptgfr


Analytical, diagnostic and therapeutic context of Ptgfr

  • Similar TUNEL staining results were found in all tissues of FP-deficient mice compared with those of wild type mice [9].
  • This study describes an effective and selective noncompetitive FP antagonist, THG113, which significantly delays preterm delivery; this provides the basis for future investigations for its use in tocolysis [2].
  • Prostaglandin E (PGE) and prostaglandin F (PGF) levels, measured by radioimmunoassay, were much reduced in the EFA deficient mice skin [23].
  • Northern blot analysis showed that the pattern of expression of the transgene corresponded to that of FP expression, except in the ovary [24].
  • PGE and PGF were determined in endometrial curettage samples [25].


  1. Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Mu, J., Kanzaki, T., Si, X., Tomimatsu, T., Fukuda, H., Shioji, M., Murata, Y., Sugimoto, Y., Ichikawa, A. Biol. Reprod. (2003) [Pubmed]
  2. THG113: a novel selective FP antagonist that delays preterm labor. Peri, K.G., Quiniou, C., Hou, X., Abran, D., Varma, D.R., Lubell, W.D., Chemtob, S. Semin. Perinatol. (2002) [Pubmed]
  3. Modulation of murine schistosomiasis by exogenously administered prostaglandins. Chensue, S.W., Remick, D.G., Higashi, G.I., Boros, D.L., Kunkel, S.L. Am. J. Pathol. (1986) [Pubmed]
  4. The in vitro effect of indomethacin on basal bone resorption, on prostaglandin production and on the response to added prostaglandins. Katz, J.M., Skinner, S.J., Wilson, T., Gray, D.H. Prostaglandins (1983) [Pubmed]
  5. Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Takayama, K., Yuhki, K., Ono, K., Fujino, T., Hara, A., Yamada, T., Kuriyama, S., Karibe, H., Okada, Y., Takahata, O., Taniguchi, T., Iijima, T., Iwasaki, H., Narumiya, S., Ushikubi, F. Nat. Med. (2005) [Pubmed]
  6. Failure of parturition in mice lacking the prostaglandin F receptor. Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., Hasumoto, K., Murata, T., Hirata, M., Ushikubi, F., Negishi, M., Ichikawa, A., Narumiya, S. Science (1997) [Pubmed]
  7. Cloning and expression of a cDNA for mouse prostaglandin F receptor. Sugimoto, Y., Hasumoto, K., Namba, T., Irie, A., Katsuyama, M., Negishi, M., Kakizuka, A., Narumiya, S., Ichikawa, A. J. Biol. Chem. (1994) [Pubmed]
  8. Suppression of mitogen-induced, cell-mediated cytotoxicity by prostaglandin F2 alpha in bronchial asthma. Podleski, W.K., Wardlow, M. Annals of allergy. (1979) [Pubmed]
  9. Apoptosis and related proteins during parturition in prostaglandin F receptor-deficient mice. Mu, J., Kanzaki, T., Si, X., Tomimatsu, T., Fukuda, H., Fujii, E., Hosono, T., Murata, Y., Sugimoto, Y., Ichikawa, A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  10. Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice. Tsuboi, K., Sugimoto, Y., Iwane, A., Yamamoto, K., Yamamoto, S., Ichikawa, A. Endocrinology (2000) [Pubmed]
  11. Hormonal regulation of prostaglandin F2 alpha receptor gene expression in mouse ovary. Sugatani, J., Masu, Y., Nishizawa, M., Sakamoto, K., Houtani, T., Sugimoto, T., Ito, S. Am. J. Physiol. (1996) [Pubmed]
  12. Characterization of prostanoid receptors in podocytes. Bek, M., Nüsing, R., Kowark, P., Henger, A., Mundel, P., Pavenstädt, H. J. Am. Soc. Nephrol. (1999) [Pubmed]
  13. Identification of a single (FP) receptor associated with prostanoid-induced Ca2+ signals in Swiss 3T3 cells. Woodward, D.F., Lawrence, R.A. Biochem. Pharmacol. (1994) [Pubmed]
  14. Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract. Saito, O., Guan, Y., Qi, Z., Davis, L.S., Kömhoff, M., Sugimoto, Y., Narumiya, S., Breyer, R.M., Breyer, M.D. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  15. Potential sites of prostaglandin actions in the periimplantation mouse uterus: differential expression and regulation of prostaglandin receptor genes. Yang, Z.M., Das, S.K., Wang, J., Sugimoto, Y., Ichikawa, A., Dey, S.K. Biol. Reprod. (1997) [Pubmed]
  16. Exogenous but not endogenous prostanoids regulate cytokine secretion from murine bone marrow dendritic cells: EP2, DP, and IP but not EP1, EP3, and FP prostanoid receptors are involved. Józefowski, S., Bobek, M., Marcinkiewicz, J. Int. Immunopharmacol. (2003) [Pubmed]
  17. Eicosapentaenoic and arachidonic acid: comparison of metabolism and activity in murine epidermal cells. Belury, M.A., Patrick, K.E., Locniskar, M., Fischer, S.M. Lipids (1989) [Pubmed]
  18. AL-3138 antagonizes FP prostanoid receptor-mediated inositol phosphates generation: comparison with some purported FP antagonists. Sharif, N.A., Crider, J.Y., Davis, T.L. J. Pharm. Pharmacol. (2000) [Pubmed]
  19. Effect of retinoic acid on prostaglandin F2 alpha-induced phospholipase D activity in osteoblast-like cells. Kozawa, O., Suzuki, A., Shinoda, J., Oiso, Y. Prostaglandins Leukot. Essent. Fatty Acids (1996) [Pubmed]
  20. Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors. Ishikawa, T.O., Tamai, Y., Rochelle, J.M., Hirata, M., Namba, T., Sugimoto, Y., Ichikawa, A., Narumiya, S., Taketo, M.M., Seldin, M.F. Genomics (1996) [Pubmed]
  21. Prostanoid EP4 receptor is involved in suppression of 3T3-L1 adipocyte differentiation. Tsuboi, H., Sugimoto, Y., Kainoh, T., Ichikawa, A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  22. Role of prostaglandin H2 synthase 2 in murine parturition: study on ovariectomy-induced parturition in prostaglandin F receptor-deficient mice. Tsuboi, K., Iwane, A., Nakazawa, S., Sugimoto, Y., Ichikawa, A. Biol. Reprod. (2003) [Pubmed]
  23. Linoleic acid effects on epidermal DNA synthesis and cutaneous prostaglandin levels in essential fatty acid deficiency. Lowe, N.J., DeQuoy, P.R. J. Invest. Dermatol. (1978) [Pubmed]
  24. Characterization of the mouse prostaglandin F receptor gene: a transgenic mouse study of a regulatory region that controls its expression in the stomach and kidney but not in the ovary. Hasumoto, K., Sugimoto, Y., Gotoh, M., Segi, E., Yamasaki, A., Yamaguchi, M., Honda, H., Hirai, H., Negishi, M., Kakizuka, A., Ichikawa, A. Genes Cells (1997) [Pubmed]
  25. Steroid and prostaglandin relations during the menstrual cycle. Jordan, V.C., Pokoly, T.B. Obstetrics and gynecology. (1977) [Pubmed]
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