The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PTGIS  -  prostaglandin I2 (prostacyclin) synthase

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PTGIS


High impact information on PTGIS


Biological context of PTGIS


Anatomical context of PTGIS


Associations of PTGIS with chemical compounds

  • PGIS shares only 16% sequence identity with human thromboxane synthase and has a different hydropathy pattern near the amino terminus, suggesting a different membrane anchoring topology [7].
  • The effect of various oxidants on bovine aortic prostacyclin synthase was tested with 14C-labelled prostaglandin endoperoxide as substrate [10].
  • Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inhibits bovine aortic prostacyclin synthase [10].
  • Studies on the interaction of minoxidil with prostacyclin synthase in vitro [11].
  • These findings coupled with our earlier demonstration of a requisite addition of exogenous arachidonate in order to observe strain-induced PGI2 release, implicates a mechanism that more likely involves strain-induced stimulation of PGIS activity [12].

Analytical, diagnostic and therapeutic context of PTGIS


  1. Hypoxia-reoxygenation triggers coronary vasospasm in isolated bovine coronary arteries via tyrosine nitration of prostacyclin synthase. Zou, M.H., Bachschmid, M. J. Exp. Med. (1999) [Pubmed]
  2. Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta. DeWitt, D.L., Day, J.S., Sonnenburg, W.K., Smith, W.L. J. Clin. Invest. (1983) [Pubmed]
  3. Specific nitration at tyrosine 430 revealed by high resolution mass spectrometry as basis for redox regulation of bovine prostacyclin synthase. Schmidt, P., Youhnovski, N., Daiber, A., Balan, A., Arsic, M., Bachschmid, M., Przybylski, M., Ullrich, V. J. Biol. Chem. (2003) [Pubmed]
  4. Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. Kozak, K.R., Crews, B.C., Morrow, J.D., Wang, L.H., Ma, Y.H., Weinander, R., Jakobsson, P.J., Marnett, L.J. J. Biol. Chem. (2002) [Pubmed]
  5. Selective nitration of prostacyclin synthase and defective vasorelaxation in atherosclerotic bovine coronary arteries. Zou, M.H., Leist, M., Ullrich, V. Am. J. Pathol. (1999) [Pubmed]
  6. Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells. Hara, S., Miyata, A., Yokoyama, C., Inoue, H., Brugger, R., Lottspeich, F., Ullrich, V., Tanabe, T. J. Biol. Chem. (1994) [Pubmed]
  7. Molecular cloning and characterization of bovine prostacyclin synthase. Pereira, B., Wu, K.K., Wang, L.H. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  8. Cellular distribution of prostacyclin synthase and specific prostacyclin binding sites in bovine corpora lutea of pregnancy. Chegini, N., Lei, Z.M., Rao, C.V. Mol. Cell. Endocrinol. (1990) [Pubmed]
  9. Characterization of monoclonal antibodies generated against bovine and porcine prostacyclin synthase and quantitation of bovine prostacyclin synthase. Siegle, I., Nüsing, R., Brugger, R., Sprenger, R., Zecher, R., Ullrich, V. FEBS Lett. (1994) [Pubmed]
  10. Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inhibits bovine aortic prostacyclin synthase. Zou, M.H., Ullrich, V. FEBS Lett. (1996) [Pubmed]
  11. Studies on the interaction of minoxidil with prostacyclin synthase in vitro. Hecker, M., Ullrich, V. Biochem. Pharmacol. (1988) [Pubmed]
  12. Cyclic strain is a weak inducer of prostacyclin synthase expression in bovine aortic endothelial cells. Segurola, R.J., Oluwole, B., Mills, I., Yokoyama, C., Tanabe, T., Kito, H., Nakajima, N., Sumpio, B.E. J. Surg. Res. (1997) [Pubmed]
  13. Bovine prostacyclin synthase: purification and isolation of partial cDNA. Pereira, B., Wu, K.K., Wang, L.H. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
WikiGenes - Universities