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Gene Review

Ptgis  -  prostaglandin I2 (prostacyclin) synthase

Rattus norvegicus

Synonyms: Cyp8, Prostacyclin synthase, Prostaglandin I2 synthase
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Disease relevance of Ptgis


High impact information on Ptgis


Chemical compound and disease context of Ptgis


Biological context of Ptgis


Anatomical context of Ptgis


Associations of Ptgis with chemical compounds

  • A single injection of rat PGIS cDNA-encoding plasmid into thigh muscle 3 days after bupivacaine pretreatment transiently increased muscle PGIS protein expression and muscle and serum levels of a stable prostacyclin metabolite (6-keto-prostaglandin F1) [2].
  • Conray did not significantly alter iNOS, COX-2, prostacyclin synthase, or PGE(2) synthase content [18].
  • Indeed, the scavenging action of indapamide significantly attenuated the inhibitory activity of 15-hydroperoxy-arachidonate to prostacyclin synthase activity [16].
  • Effect of an imidazolineoxyl nitric oxide on prostaglandin synthesis in experimental shock: possible role of nitrogen dioxide in prostacyclin synthase inactivation [3].
  • PCS gene transfer and BPS 300 micrograms/kg/day significantly suppressed the BrdU index [19].

Other interactions of Ptgis


Analytical, diagnostic and therapeutic context of Ptgis


  1. Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. Geraci, M.W., Gao, B., Shepherd, D.C., Moore, M.D., Westcott, J.Y., Fagan, K.A., Alger, L.A., Tuder, R.M., Voelkel, N.F. J. Clin. Invest. (1999) [Pubmed]
  2. Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats. Tahara, N., Kai, H., Niiyama, H., Mori, T., Sugi, Y., Takayama, N., Yasukawa, H., Numaguchi, Y., Matsui, H., Okumura, K., Imaizumi, T. Hum. Gene Ther. (2004) [Pubmed]
  3. Effect of an imidazolineoxyl nitric oxide on prostaglandin synthesis in experimental shock: possible role of nitrogen dioxide in prostacyclin synthase inactivation. Soler, M., Camacho, M., Molins-Pujol, A.M., Vila, L. J. Infect. Dis. (2001) [Pubmed]
  4. Increased splanchnic prostacyclin synthase and cyclooxygenase content and activity during ischemia is due to new protein synthesis. Myers, S.I., Evans, C.T., Hernandez, R., Bartula, L. Surgery (1994) [Pubmed]
  5. Post-suspension hypotension is attenuated in Sprague-Dawley rats by prostacyclin synthase inhibition. Bayorh, M.A., Eatman, D., Walton, M., Socci, R.R., Emmett, N. Prostaglandins Leukot. Essent. Fatty Acids (2002) [Pubmed]
  6. Up-regulation of the enzymes involved in prostacyclin synthesis via Ras induces vascular endothelial growth factor. Buchanan, F.G., Chang, W., Sheng, H., Shao, J., Morrow, J.D., DuBois, R.N. Gastroenterology (2004) [Pubmed]
  7. Expression of prostaglandin H2-mediated mechanism of vascular contraction in hypertensive rats. Relation to lipoxygenase and prostacyclin synthase activities. Lin, L., Balazy, M., Pagano, P.J., Nasjletti, A. Circ. Res. (1994) [Pubmed]
  8. Increased bioavailability of enzymes of eicosanoid synthesis in hepatic and extrahepatic tissues after portacaval shunting. Goerig, M., Wernze, H., Kommerell, B., Grün, M. Hepatology (1989) [Pubmed]
  9. Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance. Hink, U., Oelze, M., Kolb, P., Bachschmid, M., Zou, M.H., Daiber, A., Mollnau, H., August, M., Baldus, S., Tsilimingas, N., Walter, U., Ullrich, V., Münzel, T. J. Am. Coll. Cardiol. (2003) [Pubmed]
  10. Exaggerated splanchnic PGI2 release following acute hemorrhage is due to new protein synthesis. Myers, S.I., Hernandez, R. Prostaglandins Leukot. Essent. Fatty Acids (1993) [Pubmed]
  11. Increased pulmonary prostacyclin synthesis in rats with chronic hypoxic pulmonary hypertension. Blumberg, F.C., Lorenz, C., Wolf, K., Sandner, P., Riegger, G.A., Pfeifer, M. Cardiovasc. Res. (2002) [Pubmed]
  12. Interleukin 1beta decreases prostacyclin synthase activity in rat mesangial cells via endogenous peroxynitrite formation. Zou, M.H., Klein, T., Pasquet, J.P., Ullrich, V. Biochem. J. (1998) [Pubmed]
  13. Pregnancy and lipid peroxide-induced alterations of eicosanoid-metabolizing enzymes in the aorta of the rat. Davidge, S.T., Everson, W.V., Parisi, V.M., McLaughlin, M.K. Am. J. Obstet. Gynecol. (1993) [Pubmed]
  14. Rat prostacyclin synthase. Cloning and regulation of gene expression in the lung. Geraci, M., Shepherd, D., Moore, M., Vernon, J., Allard, J., Shannon, J., Voelkel, N.F. Chest (1997) [Pubmed]
  15. Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury. Numaguchi, Y., Naruse, K., Harada, M., Osanai, H., Mokuno, S., Murase, K., Matsui, H., Toki, Y., Ito, T., Okumura, K., Hayakawa, T. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  16. Radical scavengers of indapamide in prostacyclin synthesis in rat smooth muscle cell. Uehara, Y., Shirahase, H., Nagata, T., Ishimitsu, T., Morishita, S., Osumi, S., Matsuoka, H., Sugimoto, T. Hypertension (1990) [Pubmed]
  17. Prostaglandin endoperoxide synthase in rat ovarian follicles: content, cellular distribution, and evidence for hormonal induction preceding ovulation. Hedin, L., Gaddy-Kurten, D., Kurten, R., DeWitt, D.L., Smith, W.L., Richards, J.S. Endocrinology (1987) [Pubmed]
  18. Iodinated contrast induced renal vasoconstriction is due in part to the downregulation of renal cortical and medullary nitric oxide synthesis. Myers, S.I., Wang, L., Liu, F., Bartula, L.L. J. Vasc. Surg. (2006) [Pubmed]
  19. Prostacyclin synthase gene transfer inhibits neointimal formation in rat balloon-injured arteries without bleeding complications. Harada, M., Toki, Y., Numaguchi, Y., Osanai, H., Ito, T., Okumura, K., Hayakawa, T. Cardiovasc. Res. (1999) [Pubmed]
  20. On the induction of cyclooxygenase-2, inducible nitric oxide synthase and soluble phospholipase A2 in rat mesangial cells by a nonsteroidal anti-inflammatory drug: the role of cyclic AMP. Klein, T., Ullrich, V., Pfeilschifter, J., Nüsing, R. Mol. Pharmacol. (1998) [Pubmed]
  21. Prostacyclin synthase gene transfer modulates cyclooxygenase-2-derived prostanoid synthesis and inhibits neointimal formation in rat balloon-injured arteries. Yamada, M., Numaguchi, Y., Okumura, K., Harada, M., Naruse, K., Matsui, H., Ito, T., Hayakawa, T. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  22. Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats. Numaguchi, Y., Harada, M., Osanai, H., Hayashi, K., Toki, Y., Okumura, K., Ito, T., Hayakawa, T. Cardiovasc. Res. (1999) [Pubmed]
  23. Effect of cyclic AMP and prostaglandin E2 on the induction of nitric oxide- and prostanoid-forming pathways in cultured rat mesangial cells. Nüsing, R.M., Klein, T., Pfeilschifter, J., Ullrich, V. Biochem. J. (1996) [Pubmed]
  24. 17beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthase. Ospina, J.A., Krause, D.N., Duckles, S.P. Stroke (2002) [Pubmed]
  25. Oxygen-radical regulation of renal blood flow following suprarenal aortic clamping. Myers, S.I., Wang, L., Liu, F., Bartula, L.L. J. Vasc. Surg. (2006) [Pubmed]
  26. Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats. Suhara, H., Sawa, Y., Fukushima, N., Kagisaki, K., Yokoyama, C., Tanabe, T., Ohtake, S., Matsuda, H. J. Thorac. Cardiovasc. Surg. (2002) [Pubmed]
  27. Prostaglandin I2 synthase in the lymphatic endothelium of rat liver as revealed by preembedding immunoelectron microscopy. Ito, Y., Magari, S., Sakanaka, M. Lymphology. (1989) [Pubmed]
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