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Gene Review

Cd47  -  CD47 antigen (Rh-related antigen, integrin...

Mus musculus

Synonyms: 9130415E20Rik, AA407862, AI848868, AW108519, B430305P08Rik, ...
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Disease relevance of Cd47


Psychiatry related information on Cd47


High impact information on Cd47


Biological context of Cd47


Anatomical context of Cd47


Associations of Cd47 with chemical compounds


Regulatory relationships of Cd47


Other interactions of Cd47

  • Thus, CD47-SIRPalpha signaling can have a profound influence on the severity of AIHA, making manipulation of this signaling pathway a theoretically appealing avenue in the treatment of the disease [8].
  • Overexpression of CD47 resulted in the activation of both Rac and Cdc42 [3].
  • Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 (SHPS-1) is a member of the signal regulatory protein family in which the extracellular region interacts with its ligand, CD47 [20].
  • Its extracellular region interacts with the transmembrane ligand CD47 expressed on the surface of adjacent cells, and its cytoplasmic region binds the protein tyrosine phosphatases SHP-1 and SHP-2 [21].
  • Also, by transiently expressing mutant forms of this kinase, we demonstrated that Fyn is required for the integrin associated PI 3K activity [22].

Analytical, diagnostic and therapeutic context of Cd47


  1. Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Olsson, M., Bruhns, P., Frazier, W.A., Ravetch, J.V., Oldenborg, P.A. Blood (2005) [Pubmed]
  2. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Lindberg, F.P., Bullard, D.C., Caver, T.E., Gresham, H.D., Beaudet, A.L., Brown, E.J. Science (1996) [Pubmed]
  3. Promotion of neurite and filopodium formation by CD47: roles of integrins, Rac, and Cdc42. Miyashita, M., Ohnishi, H., Okazawa, H., Tomonaga, H., Hayashi, A., Fujimoto, T.T., Furuya, N., Matozaki, T. Mol. Biol. Cell (2004) [Pubmed]
  4. Functional blocking of integrin-associated protein impairs memory retention and decreases glutamate release from the hippocampus. Chang, H.P., Ma, Y.L., Wan, F.J., Tsai, L.Y., Lindberg, F.P., Lee, E.H. Neuroscience (2001) [Pubmed]
  5. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Walsh, C.P., Chaillet, J.R., Bestor, T.H. Nat. Genet. (1998) [Pubmed]
  6. Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas. Cohen, J.B., Unger, T., Rechavi, G., Canaani, E., Givol, D. Nature (1983) [Pubmed]
  7. CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis. Oldenborg, P.A., Gresham, H.D., Lindberg, F.P. J. Exp. Med. (2001) [Pubmed]
  8. Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice. Oldenborg, P.A., Gresham, H.D., Chen, Y., Izui, S., Lindberg, F.P. Blood (2002) [Pubmed]
  9. Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. Lindberg, F.P., Gresham, H.D., Schwarz, E., Brown, E.J. J. Cell Biol. (1993) [Pubmed]
  10. Ectodomain shedding of SHPS-1 and its role in regulation of cell migration. Ohnishi, H., Kobayashi, H., Okazawa, H., Ohe, Y., Tomizawa, K., Sato, R., Matozaki, T. J. Biol. Chem. (2004) [Pubmed]
  11. Resistance of B16 melanoma cells to CD47-induced negative regulation of motility as a result of aberrant N-glycosylation of SHPS-1. Ogura, T., Noguchi, T., Murai-Takebe, R., Hosooka, T., Honma, N., Kasuga, M. J. Biol. Chem. (2004) [Pubmed]
  12. Integrin-associated protein is a ligand for the P84 neural adhesion molecule. Jiang, P., Lagenaur, C.F., Narayanan, V. J. Biol. Chem. (1999) [Pubmed]
  13. Expression of a synapse-associated membrane protein, P84/SHPS-1, and its ligand, IAP/CD47, in mouse retina. Mi, Z.P., Jiang, P., Weng, W.L., Lindberg, F.P., Narayanan, V., Lagenaur, C.F. J. Comp. Neurol. (2000) [Pubmed]
  14. Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Wang, H., Verhalen, J., Madariaga, M.L., Xiang, S., Wang, S., Lan, P., Oldenborg, P.A., Sykes, M., Yang, Y.G. Blood (2007) [Pubmed]
  15. Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. Rebres, R.A., Vaz, L.E., Green, J.M., Brown, E.J. J. Biol. Chem. (2001) [Pubmed]
  16. Overexpression of integrin-associated protein (CD47) in rat kidney treated with a renal carcinogen, ferric nitrilotriacetate. Nishiyama, Y., Tanaka, T., Naitoh, H., Mori, C., Fukumoto, M., Hiai, H., Toyokuni, S. Jpn. J. Cancer Res. (1997) [Pubmed]
  17. Expression of the 50-kDa integrin-associated protein on myeloid cells and erythrocytes. Rosales, C., Gresham, H.D., Brown, E.J. J. Immunol. (1992) [Pubmed]
  18. Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1. Yamao, T., Noguchi, T., Takeuchi, O., Nishiyama, U., Morita, H., Hagiwara, T., Akahori, H., Kato, T., Inagaki, K., Okazawa, H., Hayashi, Y., Matozaki, T., Takeda, K., Akira, S., Kasuga, M. J. Biol. Chem. (2002) [Pubmed]
  19. Engagement of CD47 inhibits the contact hypersensitivity response via the suppression of motility and B7 expression by Langerhans cells. Yu, X., Fukunaga, A., Nagai, H., Oniki, S., Honma, N., Ichihashi, M., Matozaki, T., Nishigori, C., Horikawa, T. J. Invest. Dermatol. (2006) [Pubmed]
  20. Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes. Fukunaga, A., Nagai, H., Noguchi, T., Okazawa, H., Matozaki, T., Yu, X., Lagenaur, C.F., Honma, N., Ichihashi, M., Kasuga, M., Nishigori, C., Horikawa, T. J. Immunol. (2004) [Pubmed]
  21. Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. Okazawa, H., Motegi, S., Ohyama, N., Ohnishi, H., Tomizawa, T., Kaneko, Y., Oldenborg, P.A., Ishikawa, O., Matozaki, T. J. Immunol. (2005) [Pubmed]
  22. Chemoattractant induces LFA-1 associated PI 3K activity and cell migration that are dependent on Fyn signaling. Bernardini, G., Kim, J.Y., Gismondi, A., Butcher, E.C., Santoni, A. FASEB J. (2005) [Pubmed]
  23. Impaired memory retention and decreased long-term potentiation in integrin-associated protein-deficient mice. Chang, H.P., Lindberg, F.P., Wang, H.L., Huang, A.M., Lee, E.H. Learn. Mem. (1999) [Pubmed]
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