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Gene Review

Rbp4  -  retinol binding protein 4, plasma

Mus musculus

Synonyms: PRBP, Plasma retinol-binding protein, RBP, Rbp-4, Retinol-binding protein 4, ...
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Disease relevance of Rbp4

  • Using the mouse hepatoma cell line (Hepa 1-6), we examined the role of cAMP in the molecular regulation of RBP [1].
  • The Su(H) and J kappa RBP proteins are 82% identical over most of their length, and share with bacteriophage integrates and yeast recombinases a motif that includes residues directly involved in catalyzing recombination [2].
  • Serum retinol-binding protein (RBP) specifically binds to and is internalized by F9 embryonal carcinoma cells [3].
  • Studies were conducted to determine if the expression of the gene for retinol-binding protein (RBP) and/or transthyretin (TTR) could be induced upon differentiation of F9 teratocarcinoma cells to either visceral endoderm or parietal endoderm [4].

High impact information on Rbp4

  • RBP has elicited great interest lately because of its established roles in regulating gene expression, in Drosophila and mouse development, and as a component of the Notch signal transduction pathway [5].
  • Unlike wild-type mice, serum retinol levels in adult RBP(-/-) animals become undetectable after only a week on a vitamin A-deficient diet and their retinal function rapidly deteriorates [6].
  • Given a vitamin A-sufficient diet, the RBP(-/-) mice acquire normal vision by 5 months of age even though blood retinol levels remain low [6].
  • Presomitic and 3- to 12-somite pair cultured mouse embryos were deprived of retinoic acid (RA) by yolk-sac injections of antisense oligodeoxynucleotides for retinol binding protein (RBP) [7].
  • The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression [8].

Biological context of Rbp4

  • This result would suggest host flanking sequences with enhancer activity may have either activated the lacZ reporter gene or cooperated with the RBP promoter to create novel region-specific transcription [9].
  • RNase protection assays of the R197 mRNA indicate that the lacZ sequences are appropriately transcribed downstream of the RBP canonical TATA box, even though the RBP promoter is itself silent [9].
  • Our data show that retinol-RBP is the primary contributor to fetal development, whereas retinyl ester are largely responsible for accumulation of fetal retinoid stores [10].
  • The Rbp-4 locus is just proximal to Cyp-2c at the distal end of chromosome 19 [11].
  • Retinol binding protein (RBP) is the primary circulating transport molecule for retinol, facilitating its transport to target tissues and influencing target cell uptake [1].

Anatomical context of Rbp4

  • The labyrinthine region of the chorio-allantoic placenta, where exchange of substances can occur between the maternal and fetal circulations, did not contain RBP (mRNA or protein) or antigen(s) similar to the bovine RBP-receptor p63, whereas the visceral endoderm of the yolk sac placenta, the second site for materno-fetal transport, did [12].
  • RBP-null cardiac myocytes, especially in the subepicardial layer, display increased cell proliferation [13].
  • RBP contents in plasma and in liver microsomes were also similar in normal and Er/+ adults despite different retinol contents in the Er/+ tissues [14].
  • These data may suggest that there is a partial blockage in RBP secretion from TTR- hepatocytes that leads to lessened plasma levels of retinol-RBP [15].

Associations of Rbp4 with chemical compounds

  • The RBP(-/-) mice can acquire hepatic retinol stores, but these cannot be mobilized [6].
  • Dibutyryl cAMP (dbcAMP) or the adenylate cyclase activator, forskolin, increased RBP mRNA levels >6-fold at 24 h [1].
  • Cycloheximide (10 microgram/ml) did not prevent cAMP-mediated induction of RBP mRNA, indicating that de novo protein synthesis is not required for cAMP-mediated induction of RBP transcription.These studies demonstrate that cAMP, or agents which elevate intracellular cAMP, increase RBP transcript levels [1].

Other interactions of Rbp4

  • Plasma retinol binding protein (RBP) was tested as a possible candidate gene for the Er defect because of the importance of retinol as a modulator of epithelial morphogenesis and differentiation [16].
  • Most remarkably, RBP-null hearts display augmented deposition of fibronectin protein in the cardiac jelly at E9.0 through E10.5 and in the outflow tract at E12 [13].

Analytical, diagnostic and therapeutic context of Rbp4


  1. Induction of mouse retinol binding protein gene expression by cyclic AMP in Hepa 1-6 cells. Jessen, K.A., Satre, M.A. Arch. Biochem. Biophys. (1998) [Pubmed]
  2. Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Schweisguth, F., Posakony, J.W. Cell (1992) [Pubmed]
  3. Specific uptake of retinol-binding protein by variant F9 cell lines. Matarese, V., Lodish, H.F. J. Biol. Chem. (1993) [Pubmed]
  4. Induction of the expression of retinol-binding protein and transthyretin in F9 embryonal carcinoma cells differentiated to embryoid bodies. Soprano, D.R., Soprano, K.J., Wyatt, M.L., Goodman, D.S. J. Biol. Chem. (1988) [Pubmed]
  5. The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription. Olave, I., Reinberg, D., Vales, L.D. Genes Dev. (1998) [Pubmed]
  6. Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. Quadro, L., Blaner, W.S., Salchow, D.J., Vogel, S., Piantedosi, R., Gouras, P., Freeman, S., Cosma, M.P., Colantuoni, V., Gottesman, M.E. EMBO J. (1999) [Pubmed]
  7. Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis. Båvik, C., Ward, S.J., Chambon, P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  8. The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression. Kannabiran, C., Zeng, X., Vales, L.D. Mol. Cell. Biol. (1997) [Pubmed]
  9. Liver-specific and position-effect expression of a retinol-binding protein-lacZ fusion gene (RBP-lacZ) in transgenic mice. Tan, S.S. Dev. Biol. (1991) [Pubmed]
  10. Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency. Quadro, L., Hamberger, L., Gottesman, M.E., Wang, F., Colantuoni, V., Blaner, W.S., Mendelsohn, C.L. Endocrinology (2005) [Pubmed]
  11. Localization of the gene for plasma retinol binding protein to the distal half of mouse chromosome 19. Chainani, M., Sampsell, B., Elliott, R.W. Genomics (1991) [Pubmed]
  12. Retinoid binding proteins in mouse yolk sac and chorio-allantoic placentas. Johansson, S., Gustafson, A.L., Donovan, M., Romert, A., Eriksson, U., Dencker, L. Anat. Embryol. (1997) [Pubmed]
  13. Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice. Wendler, C.C., Schmoldt, A., Flentke, G.R., Case, L.C., Quadro, L., Blaner, W.S., Lough, J., Smith, S.M. Circ. Res. (2003) [Pubmed]
  14. Altered retinoid distribution in the repeated epilation (Er) mutant mouse. Jones, A.H., Lehman, P., Dale, B.A. J. Craniofac. Genet. Dev. Biol. (1992) [Pubmed]
  15. Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination. Wei, S., Episkopou, V., Piantedosi, R., Maeda, S., Shimada, K., Gottesman, M.E., Blaner, W.S. J. Biol. Chem. (1995) [Pubmed]
  16. Chromosomal localization of the retinol binding protein gene and its elimination as a candidate gene for the repeated epilation (Er) mutation in mice. Dale, B.A., Jones, A.H., Presland, R., Adler, D.A., Disteche, C.M. J. Craniofac. Genet. Dev. Biol. (1992) [Pubmed]
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