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Gene Review

Cd276  -  CD276 antigen

Mus musculus

Synonyms: 6030411F23Rik, AU016588, B7 homolog 3, B7-H3, B7RP-2, ...
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Disease relevance of Cd276


High impact information on Cd276


Biological context of Cd276

  • Taken together, these results indicate that B7-H3 and its unknown counterreceptor play a positive regulatory role in bone formation [1].
  • Although B7-H3 KO mice had no gross skeletal abnormalities, they displayed a lower bone mineral density in cortical (but not trabecular) bones compared with WT controls [1].
  • The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization [1].
  • We found that B7-H3 is highly expressed in developing bones during embryogenesis and that its expression increases as osteoblast precursor cells differentiate into mature osteoblasts [1].
  • Our results demonstrate that a dose-dependent cross-linking of a costimulatory molecule dictates the functional phenotype of the elicited effector T cell response [11].

Anatomical context of Cd276


Associations of Cd276 with chemical compounds


Physical interactions of Cd276


Regulatory relationships of Cd276


Other interactions of Cd276


Analytical, diagnostic and therapeutic context of Cd276


  1. The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Suh, W.K., Wang, S.X., Jheon, A.H., Moreno, L., Yoshinaga, S.K., Ganss, B., Sodek, J., Grynpas, M.D., Mak, T.W. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Murine B7-H3 is a negative regulator of T cells. Prasad, D.V., Nguyen, T., Li, Z., Yang, Y., Duong, J., Wang, Y., Dong, C. J. Immunol. (2004) [Pubmed]
  3. Mouse B7-H3 induces antitumor immunity. Sun, X., Vale, M., Leung, E., Kanwar, J.R., Gupta, R., Krissansen, G.W. Gene Ther. (2003) [Pubmed]
  4. Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation. Fukumoto, T., Torigoe, N., Kawabata, S., Murakami, M., Uede, T., Nishi, T., Ito, Y., Sugimura, K. Nat. Biotechnol. (1998) [Pubmed]
  5. Expression of costimulatory molecule CD40 in murine heart with acute myocarditis and reduction of inflammation by treatment with anti-CD40L/B7-1 monoclonal antibodies. Seko, Y., Takahashi, N., Azuma, M., Yagita, H., Okumura, K., Yazaki, Y. Circ. Res. (1998) [Pubmed]
  6. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Mathur, R.K., Awasthi, A., Wadhone, P., Ramanamurthy, B., Saha, B. Nat. Med. (2004) [Pubmed]
  7. Dendritic cell development and survival require distinct NF-kappaB subunits. Ouaaz, F., Arron, J., Zheng, Y., Choi, Y., Beg, A.A. Immunity (2002) [Pubmed]
  8. Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Chen, A.I., McAdam, A.J., Buhlmann, J.E., Scott, S., Lupher, M.L., Greenfield, E.A., Baum, P.R., Fanslow, W.C., Calderhead, D.M., Freeman, G.J., Sharpe, A.H. Immunity (1999) [Pubmed]
  9. Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1). Chambers, B.J., Salcedo, M., Ljunggren, H.G. Immunity (1996) [Pubmed]
  10. Duration of TCR stimulation determines costimulatory requirement of T cells. Kündig, T.M., Shahinian, A., Kawai, K., Mittrücker, H.W., Sebzda, E., Bachmann, M.F., Mak, T.W., Ohashi, P.S. Immunity (1996) [Pubmed]
  11. Differential CD40/CD40L Expression Results in Counteracting Antitumor Immune Responses. Murugaiyan, G., Agrawal, R., Mishra, G.C., Mitra, D., Saha, B. J. Immunol. (2007) [Pubmed]
  12. Enhanced Osteoclastogenesis in 4-1BB-Deficient Mice Caused by Reduced Interleukin-10. Shin, H.H., Lee, J.E., Lee, E.A., Kwon, B.S., Choi, H.S. J. Bone Miner. Res. (2006) [Pubmed]
  13. B7H1-Ig Fusion Protein Activates the CD4+ IFN-{gamma} Receptor+ Type 1 T Regulatory Subset through IFN-{gamma}-Secreting Th1 Cells. Ding, Q., Lu, L., Wang, B., Zhou, Y., Jiang, Y., Zhou, X., Xin, L., Jiao, Z., Chou, K.Y. J. Immunol. (2006) [Pubmed]
  14. Lipopolysaccharide interferes with the induction of peripheral T cell death. Vella, A.T., McCormack, J.E., Linsley, P.S., Kappler, J.W., Marrack, P. Immunity (1995) [Pubmed]
  15. Evidence that glycoprotein 96 (B2), a stress protein, functions as a Th2-specific costimulatory molecule. Banerjee, P.P., Vinay, D.S., Mathew, A., Raje, M., Parekh, V., Prasad, D.V., Kumar, A., Mitra, D., Mishra, G.C. J. Immunol. (2002) [Pubmed]
  16. Increased threshold for TCR-mediated signaling controls self reactivity of intraepithelial lymphocytes. Guehler, S.R., Finch, R.J., Bluestone, J.A., Barrett, T.A. J. Immunol. (1998) [Pubmed]
  17. Cytosine arabinoside induces costimulatory molecule expression in acute myeloid leukemia cells. Vereecque, R., Saudemont, A., Quesnel, B. Leukemia (2004) [Pubmed]
  18. Physiological concentrations of retinoic acid favor myeloid dendritic cell development over granulocyte development in cultures of bone marrow cells from mice. Hengesbach, L.M., Hoag, K.A. J. Nutr. (2004) [Pubmed]
  19. The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function. Wang, J., Foster, A., Chin, R., Yu, P., Sun, Y., Wang, Y., Pfeffer, K., Fu, Y.X. Eur. J. Immunol. (2002) [Pubmed]
  20. Enhanced activation of T cells by dendritic cells engineered to hyperexpress a triad of costimulatory molecules. Hodge, J.W., Rad, A.N., Grosenbach, D.W., Sabzevari, H., Yafal, A.G., Gritz, L., Schlom, J. J. Natl. Cancer Inst. (2000) [Pubmed]
  21. Differential T-cell activation by B7-1 expression. Li, W., Rosenzweig, A., Huber, B.T. Immunology (2003) [Pubmed]
  22. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. Guo, Y., Wu, Y., Shinde, S., Sy, M.S., Aruffo, A., Liu, Y. J. Exp. Med. (1996) [Pubmed]
  23. Heterogeneity of single cell cytokine gene expression in clonal T cell populations. Bucy, R.P., Panoskaltsis-Mortari, A., Huang, G.Q., Li, J., Karr, L., Ross, M., Russell, J.H., Murphy, K.M., Weaver, C.T. J. Exp. Med. (1994) [Pubmed]
  24. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. Murata, K., Ishii, N., Takano, H., Miura, S., Ndhlovu, L.C., Nose, M., Noda, T., Sugamura, K. J. Exp. Med. (2000) [Pubmed]
  25. Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells: modulation by tacrolimus. Morelli, A.E., Antonysamy, M.A., Takayama, T., Hackstein, H., Chen, Z., Qian, S., Zurowski, N.B., Thomson, A.W. J. Immunol. (2000) [Pubmed]
  26. Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Lu, L., McCaslin, D., Starzl, T.E., Thomson, A.W. Transplantation (1995) [Pubmed]
  27. Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness. Ohteki, T., MacDonald, H.R. Eur. J. Immunol. (1993) [Pubmed]
  28. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. Burne, M.J., Daniels, F., El Ghandour, A., Mauiyyedi, S., Colvin, R.B., O'Donnell, M.P., Rabb, H. J. Clin. Invest. (2001) [Pubmed]
  29. Murine T lymphocytes incapable of producing macrophage inhibitory protein-1 are impaired in causing graft-versus-host disease across a class I but not class II major histocompatibility complex barrier. Serody, J.S., Cook, D.N., Kirby, S.L., Reap, E., Shea, T.C., Frelinger, J.A. Blood (1999) [Pubmed]
  30. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. Takahashi, C., Mittler, R.S., Vella, A.T. J. Immunol. (1999) [Pubmed]
  31. Signal thresholds and modular synergy during expression of costimulatory molecules in B lymphocytes. Natarajan, K., Sahoo, N.C., Rao, K.V. J. Immunol. (2001) [Pubmed]
  32. The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites. Iwasaki, A., Torres, C.A., Ohashi, P.S., Robinson, H.L., Barber, B.H. J. Immunol. (1997) [Pubmed]
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