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Gene Review

Tsg101  -  tumor susceptibility gene 101

Mus musculus

Synonyms: AI255943, CC2, ESCRT-I complex subunit TSG101, Tumor susceptibility gene 101 protein
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Disease relevance of Tsg101


High impact information on Tsg101


Biological context of Tsg101


Anatomical context of Tsg101

  • Our results clearly demonstrate that Tsg101 is not a primary tumor suppressor in mouse embryonic fibroblasts [4].
  • Additionally, endocytosed EGF receptors that are normally sorted to the lysosome are instead rapidly recycled back to the cell surface in tsg101 mutant cells [7].
  • The mammalian tumor susceptibility gene tsg101 encodes the homologue of Vps23p, a class E Vps protein essential for normal membrane trafficking in the late endosome/multivesicular body of yeast [7].
  • MAb CC2 was shown to detect specifically the underlying granular material of the cyst wall without binding to the limiting membrane of the parasitophorous vacuole [8].
  • One antibody (CC2) appeared to recognize a differently expressed antigen depending on the parasite stage, reacting with a 40-kDa molecule in tachyzoites and a 115-kDa antigen in bradyzoites and oocysts [9].

Associations of Tsg101 with chemical compounds

  • Antibody CC2 reacts with a complex glycolipid which contains a branched chain oligosaccharide terminating with alpha-galactose and alpha-fucose [10].
  • OBJECTIVE: To evaluate CC2 (N, N'-dichloro-bis [2, 4, 6-trichlorophenyl] urea) in various hydrophilic and lipophilic formulations as a personnel decontaminant for sulphur mustard (SM) [11].
  • RESULTS: CC2 reacted with peanut oil and neem oil, and was unstable in povidone iodine and Fuller's earth [11].

Other interactions of Tsg101


Analytical, diagnostic and therapeutic context of Tsg101


  1. Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Wagner, K.U., Krempler, A., Qi, Y., Park, K., Henry, M.D., Triplett, A.A., Riedlinger, G., Rucker III, E.B., Hennighausen, L. Mol. Cell. Biol. (2003) [Pubmed]
  2. Clinical implications of aberrant TSG101 transcripts in acute myeloblastic leukemia. Lin, S.F., Lin, P.M., Liu, T.C., Chang, J.G., Sue, Y.C., Chen, T.P. Leuk. Lymphoma (2000) [Pubmed]
  3. Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. Carstens, M.J., Krempler, A., Triplett, A.A., Van Lohuizen, M., Wagner, K.U. J. Biol. Chem. (2004) [Pubmed]
  4. Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53-independent cell death. Krempler, A., Henry, M.D., Triplett, A.A., Wagner, K.U. J. Biol. Chem. (2002) [Pubmed]
  5. Assignment of the murine tumor susceptibility gene 101 (tsg101) and a processed tsg101 pseudogene (tsg101-ps1) to mouse chromosome 7 band B5 and chromosome 15 band D1 by in situ hybridization. Wagner, K.U., Dierisseau, P., Hennighausen, L. Cytogenet. Cell Genet. (1999) [Pubmed]
  6. The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains. Agou, F., Traincard, F., Vinolo, E., Courtois, G., Yamaoka, S., Israël, A., Véron, M. J. Biol. Chem. (2004) [Pubmed]
  7. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Babst, M., Odorizzi, G., Estepa, E.J., Emr, S.D. Traffic (2000) [Pubmed]
  8. Cyst formation by Toxoplasma gondii in vivo and in brain-cell culture: a comparative morphology and immunocytochemistry study. Sahm, M., Fischer, H.G., Gross, U., Reiter-Owona, I., Seitz, H.M. Parasitol. Res. (1997) [Pubmed]
  9. Monoclonal rat antibodies directed against Toxoplasma gondii suitable for studying tachyzoite-bradyzoite interconversion in vivo. Gross, U., Bormuth, H., Gaissmaier, C., Dittrich, C., Krenn, V., Bohne, W., Ferguson, D.J. Clin. Diagn. Lab. Immunol. (1995) [Pubmed]
  10. Subsets of olfactory and vomeronasal sensory epithelial cells and axons revealed by monoclonal antibodies to carbohydrate antigens. Schwarting, G.A., Crandall, J.E. Brain Res. (1991) [Pubmed]
  11. Evaluation of CC2 as a decontaminant in various hydrophilic and lipophilic formulations against sulphur mustard. Vijayaraghavan, R., Kumar, P., Dubey, D.K., Singh, R. Biomed. Environ. Sci. (2002) [Pubmed]
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