Gene Review:
TSG101 - tumor susceptibility 101
Homo sapiens
Synonyms:
ESCRT-I complex subunit TSG101, TSG10, Tumor susceptibility gene 101 protein, VPS23
- Retraction. The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. Li, L., Francke, U., Cohen, S.N. Cell (1998)
- The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. Stuchell, M.D., Garrus, J.E., Müller, B., Stray, K.M., Ghaffarian, S., McKinnon, R., Kräusslich, H.G., Morham, S.G., Sundquist, W.I. J. Biol. Chem. (2004)
- Overexpression of tumor susceptibility gene TSG101 in human papillary thyroid carcinomas. Liu, R.T., Huang, C.C., You, H.L., Chou, F.F., Hu, C.C., Chao, F.P., Chen, C.M., Cheng, J.T. Oncogene (2002)
- TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins. Bennett, N.A., Pattillo, R.A., Lin, R.S., Hsieh, C.Y., Murphy, T., Lyn, D. Cell. Mol. Biol. (Noisy-le-grand) (2001)
- Analysis of BRCA1, TP53, and TSG101 germline mutations in German breast and/or ovarian cancer families. Balz, V., Prisack, H.B., Bier, H., Bojar, H. Cancer Genet. Cytogenet. (2002)
- Up-regulation of tumor susceptibility gene 101 protein in ovarian carcinomas revealed by proteomics analyses. Young, T.W., Mei, F.C., Rosen, D.G., Yang, G., Li, N., Liu, J., Cheng, X. Mol. Cell Proteomics (2007)
- Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. Young, T.W., Rosen, D.G., Mei, F.C., Li, N., Liu, J., Wang, X.F., Cheng, X. Clin. Cancer Res. (2007)
- AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Strack, B., Calistri, A., Craig, S., Popova, E., Göttlinger, H.G. Cell (2003)
- DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Rountree, M.R., Bachman, K.E., Baylin, S.B. Nat. Genet. (2000)
- Absence of rearrangements in the tumour susceptibility gene TSG101 in human breast cancer. Steiner, P., Barnes, D.M., Harris, W.H., Weinberg, R.A. Nat. Genet. (1997)
- The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. Li, L., Li, X., Francke, U., Cohen, S.N. Cell (1997)
- Loss of the TSG101 leucine zipper domain in aggressive non-Hodgkin's lymphomas. Ferrer, M., Hernández, S., Campo, E., Lazo, P.A. Leukemia (2000)
- Pharmacogenomics on gastric cancer. Katoh, M., Katoh, M. Cancer Biol. Ther. (2004)
- Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. Hittelman, A.B., Burakov, D., Iñiguez-Lluhí, J.A., Freedman, L.P., Garabedian, M.J. EMBO J. (1999)
- TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. Lu, Q., Hope, L.W., Brasch, M., Reinhard, C., Cohen, S.N. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1). Oh, H., Mammucari, C., Nenci, A., Cabodi, S., Cohen, S.N., Dotto, G.P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites. Mattera, R., Puertollano, R., Smith, W.J., Bonifacino, J.S. J. Biol. Chem. (2004)
- Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours. Gayther, S.A., Barski, P., Batley, S.J., Li, L., de Foy, K.A., Cohen, S.N., Ponder, B.A., Caldas, C. Oncogene (1997)
- The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B. Katoh, K., Suzuki, H., Terasawa, Y., Mizuno, T., Yasuda, J., Shibata, H., Maki, M. Biochem. J. (2005)
- HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. Pornillos, O., Higginson, D.S., Stray, K.M., Fisher, R.D., Garrus, J.E., Payne, M., He, G.P., Wang, H.E., Morham, S.G., Sundquist, W.I. J. Cell Biol. (2003)
- Reversal of multidrug resistance of gastric cancer cells by downregulation of TSG101 with TSG101siRNA. Shen, H., Pan, Y., Han, Z., Hong, L., Liu, N., Han, S., Yao, L., Xie, H., Zhaxi, C., Shi, Y., Fan, D. Cancer Biol. Ther. (2004)
- Role of myristylation in HIV-1 Gag assembly. Bouamr, F., Scarlata, S., Carter, C. Biochemistry (2003)
- TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. Bishop, N., Woodman, P. J. Biol. Chem. (2001)
- Physical and functional interactions between Daxx and TSG101. Muromoto, R., Sugiyama, K., Yamamoto, T., Oritani, K., Shimoda, K., Matsuda, T. Biochem. Biophys. Res. Commun. (2004)
- Stabilization of the unliganded glucocorticoid receptor by TSG101. Ismaili, N., Blind, R., Garabedian, M.J. J. Biol. Chem. (2005)
- The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Bache, K.G., Slagsvold, T., Cabezas, A., Rosendal, K.R., Raiborg, C., Stenmark, H. Mol. Biol. Cell (2004)
- TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination. Burgdorf, S., Leister, P., Scheidtmann, K.H. J. Biol. Chem. (2004)
- Enhanced alpha1 microglobulin secretion from Hepatitis E virus ORF3-expressing human hepatoma cells is mediated by the tumor susceptibility gene 101. Surjit, M., Oberoi, R., Kumar, R., Lal, S.K. J. Biol. Chem. (2006)
- Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation. Razi, M., Futter, C.E. Mol. Biol. Cell (2006)
- A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control. Li, L., Liao, J., Ruland, J., Mak, T.W., Cohen, S.N. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Use of a combined ex vivo/in vivo population approach for screening of human genes involved in the human immunodeficiency virus type 1 life cycle for variants influencing disease progression. Bleiber, G., May, M., Martinez, R., Meylan, P., Ott, J., Beckmann, J.S., Telenti, A. J. Virol. (2005)