Gene Review:
Xpc - xeroderma pigmentosum, complementation...
Mus musculus
Synonyms:
DNA repair protein complementing XP-C cells homolog, Xeroderma pigmentosum group C-complementing protein homolog, p125
- DMBA-induced toxic and mutagenic responses vary dramatically between NER-deficient Xpa, Xpc and Csb mice. Wijnhoven, S.W., Kool, H.J., Mullenders, L.H., Slater, R., van Zeeland, A.A., Vrieling, H. Carcinogenesis (2001)
- Tissue specific mutagenic and carcinogenic responses in NER defective mouse models. Wijnhoven, S.W., Hoogervorst, E.M., de Waard, H., van der Horst, G.T., van Steeg, H. Mutat. Res. (2007)
- Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process. Nahari, D., McDaniel, L.D., Task, L.B., Daniel, R.L., Velasco-Miguel, S., Friedberg, E.C. DNA Repair (Amst.) (2004)
- Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors. Cheo, D.L., Meira, L.B., Burns, D.K., Reis, A.M., Issac, T., Friedberg, E.C. Cancer Res. (2000)
- Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis. van Oosten, M., Rebel, H., Friedberg, E.C., van Steeg, H., van der Horst, G.T., van Kranen, H.J., Westerman, A., van Zeeland, A.A., Mullenders, L.H., de Gruijl, F.R. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome mice. Laposa, R.R., Huang, E.J., Cleaver, J.E. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Epidermal transit of replication-arrested, undifferentiated keratinocytes in UV-exposed XPC mice: an alternative to in situ apoptosis. Stout, G.J., Westdijk, D., Calkhoven, D.M., Pijper, O., Backendorf, C.M., Willemze, R., Mullenders, L.H., de Gruijl, F.R. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions. Meira, L.B., Reis, A.M., Cheo, D.L., Nahari, D., Burns, D.K., Friedberg, E.C. Mutat. Res. (2001)
- Defective nucleotide excision repair in xpc mutant mice and its association with cancer predisposition. Friedberg, E.C., Bond, J.P., Burns, D.K., Cheo, D.L., Greenblatt, M.S., Meira, L.B., Nahari, D., Reis, A.M. Mutat. Res. (2000)
- Relationship between UV-induced mutant p53 patches and skin tumours, analysed by mutation spectra and by induction kinetics in various DNA-repair-deficient mice. Rebel, H., Kram, N., Westerman, A., Banus, S., van Kranen, H.J., de Gruijl, F.R. Carcinogenesis (2005)
- DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse. Hsia, K.T., Millar, M.R., King, S., Selfridge, J., Redhead, N.J., Melton, D.W., Saunders, P.T. Development (2003)
- Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair. Wijnhoven, S.W., Kool, H.J., Mullenders, L.H., van Zeeland, A.A., Friedberg, E.C., van der Horst, G.T., van Steeg, H., Vrieling, H. Oncogene (2000)
- Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes. van Oosten, M., Stout, G.J., Backendorf, C., Rebel, H., de Wind, N., Darroudi, F., van Kranen, H.J., de Gruijl, F.R., Mullenders, L.H. DNA Repair (Amst.) (2005)
- T cell-dependent activation of resting B cells: requirement for both nonspecific unrestricted and antigen-specific Ia-restricted soluble factors. Anderson, J., Melchers, F. Proc. Natl. Acad. Sci. U.S.A. (1981)
- The Ig-ITIM superfamily member PECAM-1 regulates the "outside-in" signaling properties of integrin alpha(IIb)beta3 in platelets. Wee, J.L., Jackson, D.E. Blood (2005)
- 2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair. Hoogervorst, E.M., van Oostrom, C.T., Beems, R.B., van Benthem, J., van den Berg, J., van Kreijl, C.F., Vos, J.G., de Vries, A., van Steeg, H. DNA Repair (Amst.) (2005)
- 3,4-Epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice. Wickliffe, J.K., Galbert, L.A., Ammenheuser, M.M., Herring, S.M., Xie, J., Masters, O.E., Friedberg, E.C., Lloyd, R.S., Ward, J.B. Environ. Mol. Mutagen. (2006)
- Focal adhesion-associated proteins p125FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells. Leeb-Lundberg, L.M., Song, X.H., Mathis, S.A. J. Biol. Chem. (1994)
- Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor. Seufferlein, T., Withers, D.J., Mann, D., Rozengurt, E. Mol. Biol. Cell (1996)
- Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells. Watanabe, T., Nakao, A., Emerling, D., Hashimoto, Y., Tsukamoto, K., Horie, Y., Kinoshita, M., Kurokawa, K. J. Biol. Chem. (1994)
- Genotype-specific Trp53 mutational analysis in ultraviolet B radiation-induced skin cancers in Xpc and Xpc Trp53 mutant mice. Reis, A.M., Cheo, D.L., Meira, L.B., Greenblatt, M.S., Bond, J.P., Nahari, D., Friedberg, E.C. Cancer Res. (2000)