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Gene Review

Tek  -  endothelial-specific receptor tyrosine kinase

Mus musculus

Synonyms: AA517024, Angiopoietin-1 receptor, Cd202b, Endothelial tyrosine kinase, HYK, ...
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Disease relevance of Tek


High impact information on Tek


Chemical compound and disease context of Tek


Biological context of Tek


Anatomical context of Tek


Associations of Tek with chemical compounds


Physical interactions of Tek


Co-localisations of Tek


Regulatory relationships of Tek


Other interactions of Tek

  • In this study, we reveal that lymphatic vascular endothelial hyaluronan receptor 1-positive (LYVE-1(+)) lymphatic endothelial cells (LECs) express Tie2 in both embryonic and adult settings, indicating that Ang signaling occurs in lymphatic vessels [15].
  • Consistent with this notion, we showed with the primitive hematopoietic colony assay that primitive erythropoietic progenitors are enriched in PECAM-1- and Tie2-positive cells [25].
  • Exogenous VEGF-A and Ang-1 stimulated Tie2 expression in the BM vasculature [10].
  • Furthermore, Tie-1 was strongly induced during repair with a prolonged expression in diabetic mice, whereas Tie-2 expression was constitutive during normal repair but completely absent in diabetes-impaired healing [26].
  • The RT-PCR analysis of the retinas of the Tek-treated animals showed a similar (80%; p = 0.001) inhibition of the MMP-9 expression, which correlated with the decrease in angiogenesis [1].

Analytical, diagnostic and therapeutic context of Tek


  1. Angiopoietin/Tek interactions regulate mmp-9 expression and retinal neovascularization. Das, A., Fanslow, W., Cerretti, D., Warren, E., Talarico, N., McGuire, P. Lab. Invest. (2003) [Pubmed]
  2. Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway. Siemeister, G., Schirner, M., Weindel, K., Reusch, P., Menrad, A., Marmé, D., Martiny-Baron, G. Cancer Res. (1999) [Pubmed]
  3. Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases. Fabris, L., Cadamuro, M., Fiorotto, R., Roskams, T., Spirlì, C., Melero, S., Sonzogni, A., Joplin, R.E., Okolicsanyi, L., Strazzabosco, M. Hepatology (2006) [Pubmed]
  4. Targeting the Tie2/Tek receptor in astrocytomas. Zadeh, G., Qian, B., Okhowat, A., Sabha, N., Kontos, C.D., Guha, A. Am. J. Pathol. (2004) [Pubmed]
  5. Angiopoietin-1, angiopoietin-2 and Tie-2 in tumour and non-tumour tissues during growth of experimental melanoma. Pomyje, J., Zivný, J.H., Stopka, T., Simák, J., Vanková, H., Necas, E. Melanoma Res. (2001) [Pubmed]
  6. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G.Y., Suda, T. Cell (2004) [Pubmed]
  7. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. De Palma, M., Venneri, M.A., Roca, C., Naldini, L. Nat. Med. (2003) [Pubmed]
  8. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Sato, T.N., Tozawa, Y., Deutsch, U., Wolburg-Buchholz, K., Fujiwara, Y., Gendron-Maguire, M., Gridley, T., Wolburg, H., Risau, W., Qin, Y. Nature (1995) [Pubmed]
  9. Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells. Kurihara, N., Iwama, A., Tatsumi, J., Ikeda, K., Suda, T. Blood (1996) [Pubmed]
  10. Tie2 activation contributes to hemangiogenic regeneration after myelosuppression. Kopp, H.G., Avecilla, S.T., Hooper, A.T., Shmelkov, S.V., Ramos, C.A., Zhang, F., Rafii, S. Blood (2005) [Pubmed]
  11. Expression and potential role of angiopoietins and Tie-2 in early development of the mouse metanephros. Kolatsi-Joannou, M., Li, X.Z., Suda, T., Yuan, H.T., Woolf, A.S. Dev. Dyn. (2001) [Pubmed]
  12. Interleukin-1beta regulates angiopoietin-1 expression in human endothelial cells. Fan, F., Stoeltzing, O., Liu, W., McCarty, M.F., Jung, Y.D., Reinmuth, N., Ellis, L.M. Cancer Res. (2004) [Pubmed]
  13. Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. Fiedler, U., Krissl, T., Koidl, S., Weiss, C., Koblizek, T., Deutsch, U., Martiny-Baron, G., Marmé, D., Augustin, H.G. J. Biol. Chem. (2003) [Pubmed]
  14. The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors. Dumont, D.J., Gradwohl, G.J., Fong, G.H., Auerbach, R., Breitman, M.L. Oncogene (1993) [Pubmed]
  15. Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Morisada, T., Oike, Y., Yamada, Y., Urano, T., Akao, M., Kubota, Y., Maekawa, H., Kimura, Y., Ohmura, M., Miyamoto, T., Nozawa, S., Koh, G.Y., Alitalo, K., Suda, T. Blood (2005) [Pubmed]
  16. Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice. Pitera, J.E., Woolf, A.S., Gale, N.W., Yancopoulos, G.D., Yuan, H.T. Am. J. Pathol. (2004) [Pubmed]
  17. Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, Ang-1, and Tie-2. Abbott, B.D., Buckalew, A.R. Dev. Dyn. (2000) [Pubmed]
  18. Expression and hypoxic regulation of angiopoietins in human astrocytomas. Ding, H., Roncari, L., Wu, X., Lau, N., Shannon, P., Nagy, A., Guha, A. Neuro-oncology (2001) [Pubmed]
  19. Vascular endothelial growth factor and angiopoietin are required for prostate regeneration. Wang, G.M., Kovalenko, B., Huang, Y., Moscatelli, D. Prostate (2007) [Pubmed]
  20. Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes. Lee, S., Kim, W., Moon, S.O., Sung, M.J., Kim, D.H., Kang, K.P., Jang, K.Y., Lee, S.Y., Park, B.H., Koh, G.Y., Park, S.K. Nephrol. Dial. Transplant. (2007) [Pubmed]
  21. The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Jones, N., Dumont, D.J. Oncogene (1998) [Pubmed]
  22. Expressional regulation of the angiopoietin-1 and -2 and the endothelial-specific receptor tyrosine kinase Tie2 in adrenal atrophy: a study of adrenocorticotropin-induced repair. Féraud, O., Mallet, C., Vilgrain, I. Endocrinology (2003) [Pubmed]
  23. Deficiency in the p110alpha subunit of PI3K results in diminished Tie2 expression and Tie2(-/-)-like vascular defects in mice. Lelievre, E., Bourbon, P.M., Duan, L.J., Nussbaum, R.L., Fong, G.H. Blood (2005) [Pubmed]
  24. Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Ara, T., Tokoyoda, K., Sugiyama, T., Egawa, T., Kawabata, K., Nagasawa, T. Immunity (2003) [Pubmed]
  25. Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo. Ema, M., Yokomizo, T., Wakamatsu, A., Terunuma, T., Yamamoto, M., Takahashi, S. Blood (2006) [Pubmed]
  26. Expressional regulation of angiopoietin-1 and -2 and the tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: a comparative study of normal and impaired repair. Kämpfer, H., Pfeilschifter, J., Frank, S. Lab. Invest. (2001) [Pubmed]
  27. Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation. Yuan, H.T., Suri, C., Yancopoulos, G.D., Woolf, A.S. J. Am. Soc. Nephrol. (1999) [Pubmed]
  28. Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development. Dunk, C., Shams, M., Nijjar, S., Rhaman, M., Qiu, Y., Bussolati, B., Ahmed, A. Am. J. Pathol. (2000) [Pubmed]
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