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KIN  -  Kin17 DNA and RNA binding protein

Homo sapiens

Synonyms: BTCD, Binding to curved DNA, DNA/RNA-binding protein KIN17, KIN, antigenic determinant of recA protein homolog, KIN17, ...
 
 
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Disease relevance of KIN

  • By recloning the cDNA into an appropriate vector, we produced kin17 protein in E. coli, purified it partially and shown that kin17 protein binds to double-stranded DNA [1].
  • Among 16 cell lines, the highest KIN17 protein level was observed in H1299 non-small cell lung cancer cells, whereas the lowest was detected in MeWo melanoma cells [2].
 

High impact information on KIN

 

Biological context of KIN

  • The human stress-activated protein kin17 accumulates in the nuclei of proliferating cells with predominant colocalization with sites of active DNA replication [4].
  • We demonstrated here that kin17 protein strongly associates in vivo with DNA fragments containing replication origins in both human HeLa and monkey CV-1 cells [4].
  • In addition, the association of kin17 protein to DNA fragments containing replication origins was also analyzed as a function of the cell cycle [4].
  • High binding of kin17 protein was found at the G(1)/S border and throughout the S phase and was negligible in both G(0) and M phases [4].
  • Cells unable to repair UVC-induced DNA damage responded to lower doses of UVC with an even greater accumulation of c-fos and Kin17 mRNAs than repair-proficient wild-type cells, suggesting that a process in which a repair protein is involved regulates mRNA stability [5].
 

Anatomical context of KIN

 

Associations of KIN with chemical compounds

  • Kin17 gene encodes a 45 kDa protein which binds to DNA and presents a limited similarity with a functional domain of the bacterial RecA protein [8].
  • After L-mimosine block and withdrawal we observed that kin17 protein was recruited in the nucleus during re-entry and progression through S phase [9].
  • In the presence of DNA damage in S phase cells, the distribution of kin17 protein became mainly associated with chromosomal DNA, as judged by limited formaldehyde cross-linking of living cells [9].
  • A Tandem of SH3-like Domains Participates in RNA Binding in KIN17, a Human Protein Activated in Response to Genotoxics [10].
  • NMR Assignment of Region 51-160 of Human KIN17, a DNA and RNA-binding Protein [11].
 

Regulatory relationships of KIN

 

Other interactions of KIN

 

Analytical, diagnostic and therapeutic context of KIN

References

  1. Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein. Angulo, J.F., Rouer, E., Mazin, A., Mattei, M.G., Tissier, A., Horellou, P., Benarous, R., Devoret, R. Nucleic Acids Res. (1991) [Pubmed]
  2. Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells. Despras, E., Miccoli, L., Créminon, C., Rouillard, D., Angulo, J.F., Biard, D.S. Radiat. Res. (2003) [Pubmed]
  3. Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication. Masson, C., Menaa, F., Pinon-Lataillade, G., Frobert, Y., Chevillard, S., Radicella, J.P., Sarasin, A., Angulo, J.F. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. Miccoli, L., Frouin, I., Novac, O., Di Paola, D., Harper, F., Zannis-Hadjopoulos, M., Maga, G., Biard, D.S., Angulo, J.F. Mol. Cell. Biol. (2005) [Pubmed]
  5. UV-Induced stabilization of c-fos and other short-lived mRNAs. Blattner, C., Kannouche, P., Litfin, M., Bender, K., Rahmsdorf, H.J., Angulo, J.F., Herrlich, P. Mol. Cell. Biol. (2000) [Pubmed]
  6. Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. Biard, D.S., Miccoli, L., Despras, E., Harper, F., Pichard, E., Créminon, C., Angulo, J.F. Mol. Cancer Res. (2003) [Pubmed]
  7. Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. Miccoli, L., Biard, D.S., Créminon, C., Angulo, J.F. Cancer Res. (2002) [Pubmed]
  8. Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells. Kannouche, P., Angulo, J.F. J. Cell. Sci. (1999) [Pubmed]
  9. Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. Miccoli, L., Biard, D.S., Frouin, I., Harper, F., Maga, G., Angulo, J.F. Nucleic Acids Res. (2003) [Pubmed]
  10. A Tandem of SH3-like Domains Participates in RNA Binding in KIN17, a Human Protein Activated in Response to Genotoxics. le Maire, A., Schiltz, M., Stura, E.A., Pinon-Lataillade, G., Couprie, J., Moutiez, M., Gondry, M., Angulo, J.F., Zinn-Justin, S. J. Mol. Biol. (2006) [Pubmed]
  11. NMR Assignment of Region 51-160 of Human KIN17, a DNA and RNA-binding Protein. Carlier, L., le Maire, A., Braud, S., Masson, C., Gondry, M., Zinn-Justin, S., Guilhaudis, L., Milazzo, I., Davoust, D., Gilquin, B., Couprie, J. J. Biomol. NMR (2006) [Pubmed]
  12. Identification of KIN (KIN17), a human gene encoding a nuclear DNA-binding protein, as a novel component of the TP53-independent response to ionizing radiation. Masson, C., Menaa, F., Pinon-Lataillade, G., Frobert, Y., Radicella, J.P., Angulo, J.F. Radiat. Res. (2001) [Pubmed]
  13. Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. Kannouche, P., Mauffrey, P., Pinon-Lataillade, G., Mattei, M.G., Sarasin, A., Daya-Grosjean, L., Angulo, J.F. Carcinogenesis (2000) [Pubmed]
  14. Crystallization and halide phasing of the C-terminal domain of human KIN17. le Maire, A., Schiltz, M., Braud, S., Gondry, M., Charbonnier, J.B., Zinn-Justin, S., Stura, E. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
 
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