Disease relevance of Tridiphane

• RET Is Constitutively Activated by Novel Tandem Mutations that Alter the Active Site Resulting in Multiple Endocrine Neoplasia Type 2B [1].
• We concluded that the Tandem Icon best meets our criteria and we advocate its use in the emergency room or ward as the first-line investigation of ectopic pregnancy [2].
• CONCLUSIONS: Tandem mass spectrometric quantification directly from residual blood spots is a useful method for the early detection of hepatorenal tyrosinemia in newborn-screening programs [3].
• Increased Genome Instability in Escherichia coli lon Mutants: Relation to Emergence of Multiple-Antibiotic-Resistant (Mar) Mutants Caused by Insertion Sequence Elements and Large Tandem Genomic Amplifications [4].
• METHODS: The concentration of PSA secreted into the extracellular fluid (ECF) in normal human prostate tissue, primary prostate cancers obtained directly from patients, and serially passageable human prostate cancer xenografts (PC-82, LNCaP, LAPC-4) were determined using Tandem assays [5].

Psychiatry related information on Tridiphane

• The particular applications within a forensic psychiatric center of the Tandem 16 computer system, utilizing both "canned psychological tests" and specialized assessment techniques, are examined and highlighted with a case vignette [6].

High impact information on Tridiphane

• DESIGN: Prospective blinded study using the Tandem PSA and free PSA assays (Hybritech Inc, San Diego, Calif) [7].
• Homologies between cell interaction molecular controlled by major histocompatibility complex- and Igh-V-linked genes that T cells use for communication. Tandem "adaptive" differentiation of producer and acceptor cells [8].
• Elsewhere we have reported an efficient method for isolating VNTR (Variable Number of Tandem Repeats) markers [9].
• Domains T1, T2, T3, and T4 were isolated by column chromatography. "Tandem domain" T1-T2 (56 kDa) is fully active in the aminoacylation of tRNA and is further cleaved with trypsin into domains T1 and T2 [10].
• Sequence Dependence of BNIP3 Transmembrane Domain Dimerization Implicates Side-chain Hydrogen Bonding and a Tandem GxxxG Motif in Specific Helix-Helix Interactions [11].

Chemical compound and disease context of Tridiphane

• Newborn screening for hepatorenal tyrosinemia: Tandem mass spectrometric quantification of succinylacetone [3].
• Mapping Noncovalent Ligand Binding to Stemloop Domains of the HIV-1 Packaging Signal by Tandem Mass Spectrometry [12].
• In 1726 men between 55 and 76 years old, 67 prostate carcinomas were detected by DRE, TRUS, and total serum PSA (Abbott IMx, Hybritech Tandem E) [13].
• Two enzyme-linked immunosorbent assays (Tandem Visual, Hybritech; Mod C1, Monoclonal Antibodies), with a sensitivity of 50 mIU of beta-HCG, were positive in 90% of ectopic pregnancies [14].

Biological context of Tridiphane

• (iii) Tandem copies of the dyad symmetry region alone cooperatively activate replication, suggesting that the region contains the actual origin of replication [15].
• The kits examined included immunoenzymometric assays (Tandem Icon hCG, Model Plus, Diapreg-25, Pregnastick, Nimbus) and reverse hemagglutination inhibition assays (NeoPregnosticon 75 Duoclon, Pregtest) [2].
• Novel Synthetic Approach Toward (+/-)-beta-Cuparenone via Palladium-Catalyzed Tandem Heck Cyclization of 1-Bromo-5-methyl-1-aryl-hexa-1,5-dien-3-ol Derivatives [16].
• We have reported elsewhere some interesting new results obtained by means of a preliminary program for finding Tandem Repeats in DNA sequences, together with a brief description of the basic ideas of the algorithm [17].
• Synthesis of Tricyclic Heterocycles via a Tandem Aryl Alkylation/Heck Coupling Sequence [18].

Anatomical context of Tridiphane

• Seminal plasma PSA was determined using Hybritech Tandem MP assay [19].
• Examination of livers from mice treated with 250 mg/kg tridiphane revealed that an increase in hepatic peroxisomes was apparent after 3 days of treatment [20].
• Prostate-specific antigen levels in patients with metastatic lymph nodes ranged from 0.7 to 130 ng/mL (Hybritech Tandem assay), with a mean level of 42 ng/mL [21].
• The transformation of the herbicide tridiphane (Tandem, Dowco 356, 2-(3,5-dichlorophenyl)-2(2,2,2-trichloroethyl)oxirane by the epoxide-metabolizing enzymes, epoxide hydrolases (EH) and glutathione S-transferases (GST), was investigated in mouse liver microsomes and cytosol [22].
• BACKGROUND: Tandem stem cell transplantation is an important treatment option for patients with myeloma and some additional tumors [23].

Associations of Tridiphane with other chemical compounds

• Paired comparison of the results from each kit indicated that the NovoClone Target assay showed significantly lower diagnostic sensitivity (P less than 0.05) than did the Tandem Icon II or Abbott TestPack, both for urine and for serum samples [24].
• Tetrahydrofuran Lignans via Tandem Oxidative Anionic-Radical Processes or Reductive Radical Cyclizations [25].
• The occurrence of the C-terminally elongated form of SP-C has implications for the in vivo processing of proSP-C and the Tandem mass spectrometry (MS/MS) was used to confirm the amino acid sequence of SP-C and the presence of palmitoyl groups covalently linked to the peptide [26].
• Tridiphane diol was a poor inhibitor of the enzymes studied, and the glutathione conjugate of tridiphane caused marked inhibition of only the GST activity (I50, 2.0 x 10(-5)M) [22].
• Therefore, it can be concluded that tridiphane has no meaningful effect on the pharmacokinetics and/or metabolism of atrazine in the rat [27].

Gene context of Tridiphane

• Establishment of a Stroma-Dependent Human Acute Myelomonocytic Leukemia Cell Line, NAMO-2, with FLT3 Tandem Duplication [28].
• We approached this question by utilizing Tandem Mass Spectrometry (MS/MS) analysis to identify proteins from normal rat kidney whole cell lysates that could interact with the C-terminal region of Cx43 [29].
• Variable Number of Tandem Repeats of TNF Receptor Type 2 Promoter as Genetic Biomarker of Susceptibility to Develop Invasive Pulmonary Aspergillosis [30].
• Negligible cross-reactivity to hK2 was measured by Tandem PSA assays (Hybritech) [31].
• 1. Tandem arrangement of two cell-cell adhesion molecules from the cadherin family has also been reported in chicken [32].

Analytical, diagnostic and therapeutic context of Tridiphane

• CONCLUSIONS: Tandem MS assay is a realistic alternative to immunoassay for the routine monitoring of CsA in transplant recipients [33].
• Occasional problems arose because of the instability of Tandem Icon QSR reagents at room temperature but this was resolved by storing the reagents at 4 degrees C. We conclude that this simplified quantitative method for hCG is reliable and suitable for use outside of the routine immunoassay laboratory [34].
• We used Tandem Icon II (Hybritech) pregnancy test reagents and evaluated the reagents for possible "false-positive" findings at the 25 int. units/L limit of hCG detectability by analyzing 100 post-menopausal and more than 4000 premenopausal serum specimens [35].
• When creatine kinase MB (CKMB) concentration was measured with intact antibody conjugate in these 81 samples, 18 (22%) samples had apparent CKMB values significantly greater than values measured with Hybritech's "Tandem -E CKMB immunoenzymetric" assay and Corning agarose-gel electrophoresis [36].
• (Hybritech Tandem assay) or digital rectal examination was suspicious for cancer [37].

References