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Chemical Compound Review

SODIUM PYRUVATE     sodium 2-oxopropanoate

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Disease relevance of pyruvic acid


High impact information on pyruvic acid


Chemical compound and disease context of pyruvic acid


Biological context of pyruvic acid

  • 3. The kinetics of the inactivating phosphorylation were investigated by measuring inactivation of the complex with MgATP2-. The apparent Km for the Mg complex of ATP was 25.5 microM; ADP was a competitive inhibitor (Ki 69.8 microM) and sodium pyruvate an uncompetitive inhibitor (Ki 2.8 microM) [16].
  • Addition of catalase or sodium pyruvate to the surfaces of agar plates increased enumeration of TCE-injured cells by as much as 100-fold, indicating that the TCE-injured cells were ultrasensitive to oxidative stress [17].
  • Treating intoxicated rats with sodium pyruvate, we hypothesized, would bypass the putative neurotoxin-induced blockade in glycolysis, thus ameliorating neurobehavioral and morphologic measures of neurotoxicity [18].
  • Midway through each study, higher culturable cell counts began to be observed on plates containing catalase or sodium pyruvate; during the latter stages of the study, the plate counts on such media were up to 1,000-fold higher than those on unsupplemented plates [19].
  • MEASUREMENTS AND MAIN RESULTS: The intravenous infusion of calcium and sodium pyruvate resulted in increased cardiac output, left ventricular contractility, and mixed venous oxygen saturation values in the experimental group compared with the control group of four dogs [20].

Anatomical context of pyruvic acid

  • Effects of sodium pyruvate in nonserum maturation medium on maturation, fertilization, and subsequent development of bovine oocytes with or without cumulus cells [21].
  • These results indicate that sodium pyruvate promotes nuclear maturation of bovine CDOs and that a continuing presence of cumulus cells during maturation is important for subsequent development of zygotes to the blastocyst stage [21].
  • In 82 tissues with microscopic granulomas and acid-fast bacilli, a significantly greater number of isolates were obtained on Middlebrook 7H10 medium with sodium pyruvate than on Stonebrink medium, Herrold egg yolk agar medium, or Lowenstein-Jensen medium (P=0.01) [22].
  • DOs, obtained by mechanically removing cells from cumulus-oocyte complexes (COCs) with a small-bore pipette, were cultured for 45 h in TCM199 supplemented with sodium pyruvate, gonadotropins, estradiol, and 10% porcine follicular fluid, with or without cysteamine (150 microM) [23].
  • Hog carotid artery segments were allowed to replete glycogen stores to over 6 micromol/g of new 13C-labeled glycogen by incubation at 37 degrees C with 5 mM [1-13C]glucose for 6-16 h and then were isometrically contracted for 3 h with 80 mM KCl in the presence of 5 mM [2-13C]glucose and either 2 mM sodium acetate or 5 mM sodium pyruvate [24].

Associations of pyruvic acid with other chemical compounds


Gene context of pyruvic acid

  • Catalase and the intracellular hydrogen peroxide scavenger sodium pyruvate decreased, while hydrogen peroxide increased HUVEC proliferation, migration and activity of eNOS [30].
  • Supplementation of the PPIX-based growth media with catalase or sodium pyruvate resulted in normal growth of the H. influenzae oxyR mutant [31].
  • In contrast, sodium pyruvate appeared to antagonize D-glucose-induced TGF-beta 1 and MCP-1 secretion [32].
  • To test the hypothesis that EP can ameliorate gut barrier dysfunction induced by other forms of inflammation, we incubated Caco-2 monolayers for 24 to 48 h with cytomix (a mixture of interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta) in the presence or absence of graded concentrations of EP or sodium pyruvate [26].
  • Because autoclaving is known to generate hydrogen peroxide in rich media, and because catalase and sodium pyruvate are known to eliminate hydrogen peroxide, it appears that the conditions of the experiments led to the selection of a hydrogen peroxide-sensitive culturable cell subpopulation [19].

Analytical, diagnostic and therapeutic context of pyruvic acid


  1. Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex. Phillis, J.W., Ren, J., O'Regan, M.H. J. Neurochem. (2001) [Pubmed]
  2. Effect of ferrous sulfate, sodium metabisulfite, and sodium pyruvate on survival of Campylobacter jejuni. Chou, S.P., Dular, R., Kasatiya, S. J. Clin. Microbiol. (1983) [Pubmed]
  3. Involvement of rpoS in the survival of Escherichia coli in the viable but non-culturable state. Boaretti, M., Lleò, M.M., Bonato, B., Signoretto, C., Canepari, P. Environ. Microbiol. (2003) [Pubmed]
  4. Heat injury and repair in Campylobacter jejuni. Palumbo, S.A. Appl. Environ. Microbiol. (1984) [Pubmed]
  5. Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine. Mongan, P.D., Capacchione, J., West, S., Karaian, J., Dubois, D., Keneally, R., Sharma, P. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  6. Inhibition of AP-1 and NF-kappaB by manganese-containing superoxide dismutase in human breast cancer cells. Li, J.J., Oberley, L.W., Fan, M., Colburn, N.H. FASEB J. (1998) [Pubmed]
  7. Effect of pyruvate on regional ventricular function in normal and stunned myocardium. Mentzer, R.M., Van Wylen, D.G., Sodhi, J., Weiss, R.J., Lasley, R.D., Willis, J., Bünger, R., Habil, n.u.l.l., Flint, L.M. Ann. Surg. (1989) [Pubmed]
  8. Amino acid metabolism of myeloma cells in culture. Roberts, R.S., Hsu, H.W., Lin, K.D., Yang, T.J. J. Cell. Sci. (1976) [Pubmed]
  9. Heat shock inactivates cellular antioxidant defenses against hydrogen peroxide: protection by glucose. Lord-Fontaine, S., Averill-Bates, D.A. Free Radic. Biol. Med. (2002) [Pubmed]
  10. Efficacy of vitamin E, phosphatidyl choline, and pyruvate on buffering neuronal degeneration and oxidative stress in cultured cortical neurons and in central nervous tissue of apolipoprotein E-deficient mice. Shea, T.B., Ekinci, F.J., Ortiz, D., Dawn-Linsley, M., Wilson, T.O., Nicolosi, R.J. Free Radic. Biol. Med. (2002) [Pubmed]
  11. Evaluation of cultural techniques for isolating Campylobacter pyloridis from endoscopic biopsies of gastric mucosa. Goodwin, C.S., Blincow, E.D., Warren, J.R., Waters, T.E., Sanderson, C.R., Easton, L. J. Clin. Pathol. (1985) [Pubmed]
  12. Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock. Slovin, P.N., Huang, C.J., Cade, J.R., Wood, C.E., Nasiroglu, O., Privette, M., Orbach, P., Skimming, J.W. Resuscitation. (2001) [Pubmed]
  13. Improved detection of acid mine water stressed coliform bacteria on media containing catalase and sodium pyruvate. Calabrese, J.P., Bissonnette, G.K. Can. J. Microbiol. (1990) [Pubmed]
  14. Rapid determination of Listeria monocytogenes in foods using a resuscitation/selection/kit system detection. Martin, A., Katz, S.E. Journal of AOAC International. (1993) [Pubmed]
  15. Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate. Zhao, W., Devamanoharan, P.S., Henein, M., Ali, A.H., Varma, S.D. Diabetes, obesity & metabolism. (2000) [Pubmed]
  16. Regulation of kinase reactions in pig heart pyruvate dehydrogenase complex. Kerbey, A.L., Radcliffe, P.M., Randle, P.J., Sugden, P.H. Biochem. J. (1979) [Pubmed]
  17. Cytotoxicity associated with trichloroethylene oxidation in Burkholderia cepacia G4. Yeager, C.M., Bottomley, P.J., Arp, D.J. Appl. Environ. Microbiol. (2001) [Pubmed]
  18. Does pyruvate prevent acrylamide neurotoxicity? Implications for disease pathogenesis. Sterman, A.B., Panasci, D.J., Persons, W. Exp. Neurol. (1983) [Pubmed]
  19. Recovery of hydrogen peroxide-sensitive culturable cells of Vibrio vulnificus gives the appearance of resuscitation from a viable but nonculturable state. Bogosian, G., Aardema, N.D., Bourneuf, E.V., Morris, P.J., O'Neil, J.P. J. Bacteriol. (2000) [Pubmed]
  20. Hemodynamic effects of intravenous pyruvate in the intact, anesthetized dog. Yanos, J., Patti, M.J., Stanko, R.T. Crit. Care Med. (1994) [Pubmed]
  21. Effects of sodium pyruvate in nonserum maturation medium on maturation, fertilization, and subsequent development of bovine oocytes with or without cumulus cells. Geshi, M., Takenouchi, N., Yamauchi, N., Nagai, T. Biol. Reprod. (2000) [Pubmed]
  22. Comparison of four culture media for isolation of Mycobacterium avium complex from porcine tissues. Thoen, C.O., Himes, E.M., Jarnagin, J.L., Harrington, R. J. Clin. Microbiol. (1979) [Pubmed]
  23. Male pronuclear formation in denuded porcine oocytes after in vitro maturation in the presence of cysteamine. Yamauchi, N., Nagai, T. Biol. Reprod. (1999) [Pubmed]
  24. Differential regulation of glucose and glycogen metabolism in vascular smooth muscle by exogenous substrates. Hardin, C.D., Roberts, T.M. J. Mol. Cell. Cardiol. (1997) [Pubmed]
  25. Pyruvate neutralizes peritoneal dialysate cytotoxicity: maintained integrity and proliferation of cultured human mesothelial cells. Brunkhorst, R., Mahiout, A. Kidney Int. (1995) [Pubmed]
  26. Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers. Sappington, P.L., Han, X., Yang, R., Delude, R.L., Fink, M.P. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  27. Fermentative metabolism of pyruvate by Rhodospirillum rubrum after anaerobic growth in darkness. Gorrell, T.E., Uffen, R.L. J. Bacteriol. (1977) [Pubmed]
  28. Antagonism of [3H]fatty acid incorporation into vimentin by sodium pyruvate: pitfalls of protein acylation. Cenedella, R.J., Mitchell, J. Lipids (1993) [Pubmed]
  29. Rapid separation of dehydrogenases by affinity chromatography with new induced specificity phases. Torreilles, J., Guérin, M.C., Descomps, B. Biochimie (1986) [Pubmed]
  30. Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity. Polytarchou, C., Papadimitriou, E. Eur. J. Pharmacol. (2005) [Pubmed]
  31. Lack of expression of the global regulator OxyR in Haemophilus influenzae has a profound effect on growth phenotype. Maciver, I., Hansen, E.J. Infect. Immun. (1996) [Pubmed]
  32. Glucose-mediated induction of TGF-beta 1 and MCP-1 in mesothelial cells in vitro is osmolality and polyol pathway dependent. Wong, T.Y., Phillips, A.O., Witowski, J., Topley, N. Kidney Int. (2003) [Pubmed]
  33. Improving stable transfection efficiency: antioxidants dramatically improve the outgrowth of clones under dominant marker selection. Brielmeier, M., Béchet, J.M., Falk, M.H., Pawlita, M., Polack, A., Bornkamm, G.W. Nucleic Acids Res. (1998) [Pubmed]
  34. Behavior of an Aeromonas hydrophila aroA live vaccine in water microcosms. Vivas, J., Carracedo, B., Riaño, J., Razquin, B.E., López-Fierro, P., Acosta, F., Naharro, G., Villena, A.J. Appl. Environ. Microbiol. (2004) [Pubmed]
  35. Improved membrane filtration method incorporating catalase and sodium pyruvate for detection of chlorine-stressed coliform bacteria. Calabrese, J.P., Bissonnette, G.K. Appl. Environ. Microbiol. (1990) [Pubmed]
  36. Sodium pyruvate protects against H(2)O(2) mediated apoptosis in human neuroblastoma cell line-SK-N-MC. Jagtap, J.C., Chandele, A., Chopde, B.A., Shastry, P. J. Chem. Neuroanat. (2003) [Pubmed]
  37. Anti-inflammatory activity of sodium pyruvate--a physiological antioxidant. Gupta, S.K., Rastogi, S., Prakash, J., Joshi, S., Gupta, Y.K., Awor, L., Verma, S.D. Indian J. Physiol. Pharmacol. (2000) [Pubmed]
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