Disease relevance of Laryngectomy

• This study was designed to evaluate the effects of a gastroesophageal reflux prophylaxis regimen on the incidence of fistula after laryngectomy [1].
• T2 glottic carcinomas treated by initial supracricoid partial laryngectomy in a selected series have yielded very high DSS rates with better organ preservation than was observed in the present series [2].
• To assess the ability of simultaneous cisplatin, 5-Fluorouracil, and radiation to substitute for surgery and radiation in advanced head and neck cancer, we have retrospectively selected from our phase II study a subgroup of 29 patients having primary disease requiring either more than a hemiglossectomy or a laryngectomy for control [3].
• Stomal relapses in laryngectomized patients without HT/SPD have been more frequent (0.55% rate per month) than in those treated with laryngectomy and HT/SPD (0.07% rate per month) [4].
• One hundred and two cases of laryngeal squamous cell carcinoma, all treated in the same center with total or supraglottic laryngectomy, bilateral neck dissection and postoperative radiotherapy, were investigated with both Ki67 and MIB-1 monoclonal antibodies [5].

High impact information on Laryngectomy

• Neoadjuvant cisplatin-based chemotherapy was administered to nine patients who would have required a total laryngectomy if their primary tumors had been surgically managed [6].
• Positron emission tomography scans revealed increased FDG uptake in the larynx in five patients and laryngectomy confirmed the presence of carcinoma in these patients [7].
• Normal parts from laryngectomies contained, in addition, significant amounts of active MMP-2 [8].
• BACKGROUND: To evaluate the effect of paclitaxel/cisplatin induction chemotherapy (ICHT) and CT-based radiotherapy (RT) on larynx preservation, tumor control, and survival in patients with larynx/hypopharynx carcinoma eligible for total laryngectomy (TL) or TL plus partial pharyngectomy (TLPP) [9].
• Surgical management of gastroesophageal reflux and outcome after laryngectomy in patients using tracheoesophageal speech [10].

Chemical compound and disease context of Laryngectomy

• OSAS may arise in the post-operative period of reconstructive laryngectomy for glottic carcinoma and can be managed by CO2 laser vaporization (laryngeal edema in the reconstructed area) in association with nCPAP treatment [11].
• Wound infection following laryngectomy. The effect of topical ampicillin and carbenicillin [12].

Biological context of Laryngectomy

• Relative a priori utility of several intervals of gentamicin or tobramycin (AMG) peak and trough serum levels were assigned by a group of pharmacokinetics experts, assuming prophylactic administration for laryngectomy interventions [13].
• Between 1981-1999, 75 patients treated for supraglottic SCC with horizontal supraglottic laryngectomy (HSL) at the Otolaryngology Head and Neck Surgery Department of Lausanne University Hospital were retrospectively studied [14].
• Four patients had wound healing problems; 1 of them developed a laryngotracheocutaneous fistula 15 months after SCL-CHP as a consequence of chondronecrosis, prompting total laryngectomy [15].

Anatomical context of Laryngectomy

• Each dog underwent laryngectomy and serial coronal sections of paraffin blocks from the posterior part of the vocal folds were made [16].
• METHODS: Sixty patients who had undergone total laryngectomy received a videofiberoptic examination of the PES and esophagus at the OPD office during follow-up [17].
• The cyclic AMP response to thyrotrophin (TSH) has been investigated in cells prepared from human thyroid tissue obtained during surgery for subtotal laryngectomy, and maintained under in vitro conditions as primary monolayer cultures [18].

Associations of Laryngectomy with chemical compounds

• During the last 30 years, there has been expansion of the role of endoscopic partial laryngectomy procedures since Jako, Strong, and Vaughan explored the possibilities of CO2 laser microlaryngeal procedures [19].
• Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole [20].
• The patient's management before augmentation with collagen included extended supraglottic laryngectomy, radiation therapy, and Polytef injection [21].
• The patient was acutely managed with intravenous fluids, furosemide, and zoledronic acid and then underwent a total laryngectomy and modified radical neck dissection [22].
• A 15-year retrospective analysis was carried out at the University of Illinois College of Medicine, Chicago, reviewing the tumor staging and pathology data of 239 patients treated for carcinoma of the larynx and hypopharynx requiring laryngectomy alone, laryngectomy with neck dissection, or laryngopharyngectomy and neck dissection [23].

Gene context of Laryngectomy

• Laryngectomy seems to erase the prognostic impact of EGFR expression [24].
• In order to test this concept further, neoplastic tissues from 68 patients (64 males, 4 females) were obtained during planned total laryngectomies and were tested for the presence of androgen (AR) and estrogen (ER) receptors [25].
• Subtotal laryngectomy with cricohyoidopexy (CHP) results in a satisfactory cure rate in selected T1b, T2, and T3 supraglottic and glottic cancers [26].
• Pulmonary function after total laryngectomy [27].
• METHODS: Twenty-one patients underwent frontolateral laryngectomy for radiation failure, T1 and T2 glottic SCC, at the Cancer Institute Hospital, Tokyo, from 1976 to 1991 [28].

Analytical, diagnostic and therapeutic context of Laryngectomy

• These two patients had an esophagocutaneous fistula following laryngectomy and a Flamingo Wall stent was used [29].
• Use of injectable hydroxyapatite in the secondary setting to restore glottic competence after partial laryngectomy with arytenoidectomy [30].
• First clinical experience with a new non-indwelling voice prosthesis (Provox NID) for voice rehabilitation after total laryngectomy [31].

References