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MeSH Review


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Disease relevance of Laryngectomy


High impact information on Laryngectomy


Chemical compound and disease context of Laryngectomy


Biological context of Laryngectomy

  • Relative a priori utility of several intervals of gentamicin or tobramycin (AMG) peak and trough serum levels were assigned by a group of pharmacokinetics experts, assuming prophylactic administration for laryngectomy interventions [13].
  • Between 1981-1999, 75 patients treated for supraglottic SCC with horizontal supraglottic laryngectomy (HSL) at the Otolaryngology Head and Neck Surgery Department of Lausanne University Hospital were retrospectively studied [14].
  • Four patients had wound healing problems; 1 of them developed a laryngotracheocutaneous fistula 15 months after SCL-CHP as a consequence of chondronecrosis, prompting total laryngectomy [15].

Anatomical context of Laryngectomy

  • Each dog underwent laryngectomy and serial coronal sections of paraffin blocks from the posterior part of the vocal folds were made [16].
  • METHODS: Sixty patients who had undergone total laryngectomy received a videofiberoptic examination of the PES and esophagus at the OPD office during follow-up [17].
  • The cyclic AMP response to thyrotrophin (TSH) has been investigated in cells prepared from human thyroid tissue obtained during surgery for subtotal laryngectomy, and maintained under in vitro conditions as primary monolayer cultures [18].

Associations of Laryngectomy with chemical compounds


Gene context of Laryngectomy

  • Laryngectomy seems to erase the prognostic impact of EGFR expression [24].
  • In order to test this concept further, neoplastic tissues from 68 patients (64 males, 4 females) were obtained during planned total laryngectomies and were tested for the presence of androgen (AR) and estrogen (ER) receptors [25].
  • Subtotal laryngectomy with cricohyoidopexy (CHP) results in a satisfactory cure rate in selected T1b, T2, and T3 supraglottic and glottic cancers [26].
  • Pulmonary function after total laryngectomy [27].
  • METHODS: Twenty-one patients underwent frontolateral laryngectomy for radiation failure, T1 and T2 glottic SCC, at the Cancer Institute Hospital, Tokyo, from 1976 to 1991 [28].

Analytical, diagnostic and therapeutic context of Laryngectomy


  1. Gastroesophageal reflux prophylaxis decreases the incidence of pharyngocutaneous fistula after total laryngectomy. Seikaly, H., Park, P. Laryngoscope (1995) [Pubmed]
  2. Cancer of the larynx--treatment results after primary radiotherapy with salvage surgery in a series of 1005 patients. Jørgensen, K., Godballe, C., Hansen, O., Bastholt, L. Acta oncologica (Stockholm, Sweden) (2002) [Pubmed]
  3. Concomitant chemotherapy and split-course radiation for cure and preservation of speech and swallowing in head and neck cancer. Hirsch, S.M., Caldarelli, D.D., Hutchinson, J.C., Holinger, L.D., Murthy, A.K., Showell, J.L., Taylor, S.G. Laryngoscope (1991) [Pubmed]
  4. Surgical treatment of laryngeal carcinoma with subglottis involvement. Chiesa, F., Tradati, N., Calabrese, L., Zurrida, S., DePaoli, F., Costa, L., Molinari, R. Oncol. Rep. (2001) [Pubmed]
  5. High prognostic impact of growth fraction parameters in advanced stage laryngeal squamous cell carcinoma. Valente, G., Giusti, U., Kerim, S., Gabriele, P., Motta, M., Ragona, R., Navone, R., Palestro, G. Oncol. Rep. (1999) [Pubmed]
  6. Long-term regional control after radiation therapy and neck dissection for base of tongue carcinoma. Lee, H.J., Zelefsky, M.J., Kraus, D.H., Pfister, D.G., Strong, E.W., Raben, A., Shah, J.P., Harrison, L.B. Int. J. Radiat. Oncol. Biol. Phys. (1997) [Pubmed]
  7. Distinguishing tumor recurrence from irradiation sequelae with positron emission tomography in patients treated for larynx cancer. Greven, K.M., Williams, D.W., Keyes, J.W., McGuirt, W.F., Harkness, B.A., Watson, N.E., Raben, M., Frazier, L.C., Geisinger, K.R., Cappellari, J.O. Int. J. Radiat. Oncol. Biol. Phys. (1994) [Pubmed]
  8. Diagnostic and classification value of metalloproteinases in squamous human laryngeal carcinoma. Christopoulos, T.A., Papageorgakopoulou, N., Theocharis, D.A., Aletras, A.J., Tsiganos, C.P., Papadas, T.A., Mastronikolis, N.S., Goumas, P., Vynios, D.H. Int. J. Oncol. (2004) [Pubmed]
  9. Induction chemotherapy with paclitaxel and cisplatin and CT-based 3D radiotherapy in patients with advanced laryngeal and hypopharyngeal carcinomas--a possibility for organ preservation. Pfreundner, L., Hoppe, F., Willner, J., Preisler, V., Bratengeier, K., Hagen, R., Helms, J., Flentje, M. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2003) [Pubmed]
  10. Surgical management of gastroesophageal reflux and outcome after laryngectomy in patients using tracheoesophageal speech. Jobe, B.A., Rosenthal, E., Wiesberg, T.T., Cohen, J.I., Domreis, J.S., Deveney, C.W., Sheppard, B. Am. J. Surg. (2002) [Pubmed]
  11. Obstructive sleep apnea syndrome after reconstructive laryngectomy for glottic carcinoma. Rombaux, P., Hamoir, M., Plouin-Gaudon, I., Liistro, G., Aubert, G., Rodenstein, D. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. (2000) [Pubmed]
  12. Wound infection following laryngectomy. The effect of topical ampicillin and carbenicillin. Robinson, J.M. The Journal of laryngology and otology. (1976) [Pubmed]
  13. Selection of optimal prophylactic aminoglycoside dosage in cancer patients: population pharmacokinetic approaches. Ordovás, J.P., Ronchera, C.L., Poveda, J.L., Jiménez, N.V., López, R. Journal of clinical pharmacy and therapeutics. (1994) [Pubmed]
  14. Horizontal partial laryngectomy for supraglottic squamous cell carcinoma. Bron, L.P., Soldati, D., Monod, M.L., Mégevand, C., Brossard, E., Monnier, P., Pasche, P. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. (2005) [Pubmed]
  15. Supracricoid laryngectomy with cricohyoidopexy for recurrence of early-stage glottic carcinoma after irradiation. Long-term oncological and functional results. Marchese-Ragona, R., Marioni, G., Chiarello, G., Staffieri, A., Pastore, A. Acta Otolaryngol. (2005) [Pubmed]
  16. Histology of injected autologous fascia in the paralyzed canine vocal fold. Reijonen, P., Leivo, I., Nevalainen, T., Rihkanen, H. Laryngoscope (2001) [Pubmed]
  17. Videofiberoptic examination of the pharyngoesophageal segment and esophagus in patients after total laryngectomy. Chu, P.Y., Guo, Y.C., Tai, S.K., Hwang, J.L., Tsai, T.L., Chang, S.Y. Head & neck. (2003) [Pubmed]
  18. Characterisation of the cyclic AMP response to thyrotrophin in monolayer cultures of normal human thyroid cells. Bidey, S.P., Marshall, N.J., Ekins, R.P. Acta Endocrinol. (1981) [Pubmed]
  19. Technique of en block laser endoscopic frontolateral laryngectomy for glottic cancer. Zeitels, S.M., Dailey, S.H., Burns, J.A. Laryngoscope (2004) [Pubmed]
  20. Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. Johansen, L.V., Overgaard, J., Elbrønd, O. Cancer (1988) [Pubmed]
  21. Persistence of injectable collagen in the human larynx: a histopathologic study. Ford, C.N., Gilchrist, K.W., Bartell, T.E. Laryngoscope (1987) [Pubmed]
  22. Parathyroid hormone-related peptide as a cause of hypercalcemia in squamous cell carcinoma of the head and neck: a case presentation and subject review. Brawner, J.T., Zitsch, R.P. Head & neck. (2004) [Pubmed]
  23. The submandibular triangle in squamous cell carcinoma of the larynx and hypopharynx. Wenig, B.L., Applebaum, E.L. Laryngoscope (1991) [Pubmed]
  24. Prognostic impact of the epidermal growth factor receptor levels for patients with larynx and hypopharynx cancer. Pivot, X., Magné, N., Guardiola, E., Poissonnet, G., Dassonville, O., Francoual, M., Formento, J.L., Bensadoun, R.J., Demard, F., Schneider, M., Milano, G. Oral Oncol. (2005) [Pubmed]
  25. Cytoplasmic steroid receptors in cancer of the larynx. Reiner, Z., Cvrtila, D., Petric, V. Archives of oto-rhino-laryngology. (1988) [Pubmed]
  26. Supracricoid laryngectomy with cricohyoidopexy (CHP) in the treatment of laryngeal cancer: a functional and oncologic experience. de Vincentiis, M., Minni, A., Gallo, A. Laryngoscope (1996) [Pubmed]
  27. Pulmonary function after total laryngectomy. Hess, M.M., Schwenk, R.A., Frank, W., Loddenkemper, R. Laryngoscope (1999) [Pubmed]
  28. Partial laryngectomy in the treatment of radiation-failure of early glottic carcinoma. Nibu, K., Kamata, S., Kawabata, K., Nakamizo, M., Nigauri, T., Hoki, K. Head & neck. (1997) [Pubmed]
  29. Endoprosthesis implantation at the pharyngo-esophageal level: Problems, limitations and challenges. Eleftheriadis, E., Kotzampassi, K. World J. Gastroenterol. (2006) [Pubmed]
  30. Use of injectable hydroxyapatite in the secondary setting to restore glottic competence after partial laryngectomy with arytenoidectomy. Lee, B., Woo, P. The Annals of otology, rhinology, and laryngology. (2004) [Pubmed]
  31. First clinical experience with a new non-indwelling voice prosthesis (Provox NID) for voice rehabilitation after total laryngectomy. Hancock, K., Houghton, B., Van As-Brooks, C.J., Coman, W. Acta Otolaryngol. (2005) [Pubmed]
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