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Gene Review

MAPK8IP2  -  mitogen-activated protein kinase 8...

Homo sapiens

Synonyms: C-Jun-amino-terminal kinase-interacting protein 2, IB-2, IB2, Islet-brain-2, JIP-2, ...
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Disease relevance of MAPK8IP2


High impact information on MAPK8IP2

  • METHODS: We studied primary tumours and 156 lymph nodes from 32 patients with cervical cancer (stage IA2, IB1, and IB2) and 32 lymph nodes from nine patients with benign disease [6].
  • PATIENTS AND METHODS: Patients with squamous cell, International Federation of Gynecology and Obstetrics stage IB2 to III cervical cancer were eligible for the study [7].
  • Overexpression of JIP1b slightly enhances the JNK-dependent threonine phosphorylation of APP in cultured cells, but that of JIP2 suppresses it [8].
  • We previously found that the JNK-interacting proteins JIP1b and JIP2 associate with the cytoplasmic domain of the Alzheimer's amyloid precursor protein (APP) (Taru, H., Iijima, K., Hase, M., Kirino, Y., Yagi, Y., and Suzuki, T. (2002) J. Biol. Chem. 277, 20070-20078) [9].
  • Forty-one patients with histologic diagnosis of cervical carcinoma, with no previous treatment and staged as IB2 to IIIB, were treated with three 21-day courses of cisplatin 100 mg/m2 day I and gemcitabine 1000 mg/m2 days 1 and 8, followed by locoregional treatment with either surgery or concomitant chemoradiation [10].

Biological context of MAPK8IP2


Anatomical context of MAPK8IP2


Associations of MAPK8IP2 with chemical compounds

  • PATIENTS AND METHODS: Sixteen pts (group I), FIGO stage IB1 (1), IB2 (4), IIB (10), IIIB (1), received external beam radiotherapy (EBT) with a total dose of 45 Gy in 5 weeks and concomitant CISPLATIN 40 mg/m(2) weekly, followed by BT up to a total dose of 15 Gy [17].
  • We investigated the feasibility of sentinel lymph node (SN) identification using radioisotopic lymphatic mapping with technetium-99m-labeled nanocolloid and blue-dye injection in 100 patients with early cervical cancer (FIGO stage IB1 in 58, IB2 in 18, and IIA in 24) undergoing radical hysterectomy with pelvic lymphadenectomy [18].
  • Ten consecutive patients clinically staged IB1, IB2 and IIA were treated with a neoadjuvant immunotherapy regimen that consisted in a single IV dose of cyclophosphamide at 300 mg/m2 on day 1, oral indomethacin or ibuprofen and zinc sulfate were administered from days I to 21 and 10 regional perilymphatic injections of IRX-2 on days 3 to 14 [19].
  • Forty-one untreated cervical carcinoma patients staged as IB2 to IIIB received three 21-day courses of cisplatin 100mg/m2 on day 1 and gemcitabine 1000 mg/m2 on days 1 and 8 followed by surgery or concomitant chemoradiation [20].
  • Fifteen women with International Federation of Gynecology and Obstetrics (FIGO) stages IB2 through IIIB or recurrent carcinoma of the cervix were treated with megavoltage irradiation and weekly intravenous carboplatin (7 women, 60 mg/m2; 8 women, 90 mg/m2) [21].

Physical interactions of MAPK8IP2


Regulatory relationships of MAPK8IP2

  • These data establish IB2 as a novel scaffold protein that regulates the JNK signaling pathway in brain and pancreatic beta-cells and indicate that IB2 represents a novel candidate gene for diabetes [11].

Analytical, diagnostic and therapeutic context of MAPK8IP2

  • Patients with locally advanced cervical cancer (stage IB2, IIA or IIB, 10 patients) underwent laparoscopic pelvic and para-aortic lymphadenectomy after SN biopsy and prior neoadjuvant concomitant chemoradiotherapy [22].
  • The 10-year disease-free survival (DFS) rate was 88% for Stage IB1, 44% for Stage IB2, 65% for Stage IIA, and 48% for Stage IIB [23].
  • A comparison of stages IB1 and IB2 cervical cancers treated with radical hysterectomy. Is size the real difference [24]?
  • The patient's age, clinical stage (IB1 or IB2), histological classification, grade of differentiation, tumor volume, and lymphatic vascular space invasion (LVSI) were evaluated [25].
  • RESULTS: Regarding the stage of our cases, 3 of them were IB1, IB2 and IIB; the more advanced the stage, the fewer lymphadenectomies were performed by laparoscopy [26].


  1. Identification of an internalising peptide in differentiated Calu-3 cells by phage display technology; application to gene delivery to the airways. Florea, B.I., Molenaar, T.J., Bot, I., Michon, I.N., Kuiper, J., Van Berkel, T.J., Junginger, H.E., Biessen, E.A., Borchard, G. Journal of drug targeting. (2003) [Pubmed]
  2. Detection of sentinel lymph nodes in cervical cancer. A comparison of two protocols. Kraft, O., Sevcík, L., Klát, J., Koliba, P., Curík, R., Kríozvá, H. Nuclear medicine review. Central & Eastern Europe : journal of Bulgarian, Czech, Macedonian, Polish, Romanian, Russian, Slovak, Yugoslav societies of nuclear medicine and Ukrainian Society of Radiology. (2006) [Pubmed]
  3. The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer. Holschneider, C.H., Baldwin, R.L., Tumber, K., Aoyama, C., Karlan, B.Y. Clin. Cancer Res. (2005) [Pubmed]
  4. Neoadjuvant gemcitabine and cisplatin followed by radical surgery in (bulky) squamous cell carcinoma of cervix stage IB2. Termrungruanglert, W., Tresukosol, D., Vasuratna, A., Sittisomwong, T., Lertkhachonsuk, R., Sirisabya, N. Gynecol. Oncol. (2005) [Pubmed]
  5. Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy for women with locally advanced carcinoma of the uterine cervix-Final results of a prospective phase II-study. Vrdoljak, E., Omrcen, T., Novakovi??, Z.S., Jelavi??, T.B., Prskalo, T., Hrepi??, D., Hamm, W. Gynecol. Oncol. (2006) [Pubmed]
  6. Molecular quantification and mapping of lymph-node micrometastases in cervical cancer. Van Trappen, P.O., Gyselman, V.G., Lowe, D.G., Ryan, A., Oram, D.H., Bosze, P., Weekes, A.R., Shepherd, J.H., Dorudi, S., Bustin, S.A., Jacobs, I.J. Lancet (2001) [Pubmed]
  7. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. Benedetti-Panici, P., Greggi, S., Colombo, A., Amoroso, M., Smaniotto, D., Giannarelli, D., Amunni, G., Raspagliesi, F., Zola, P., Mangioni, C., Landoni, F. J. Clin. Oncol. (2002) [Pubmed]
  8. Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. Taru, H., Iijima, K., Hase, M., Kirino, Y., Yagi, Y., Suzuki, T. J. Biol. Chem. (2002) [Pubmed]
  9. Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. Taru, H., Kirino, Y., Suzuki, T. J. Biol. Chem. (2002) [Pubmed]
  10. A phase II study of gemcitabine and cisplatin combination as induction chemotherapy for untreated locally advanced cervical carcinoma. Dueñas-Gonzalez, A., Lopez-Graniel, C., Gonzalez, A., Reyes, M., Mota, A., Muñoz, D., Solorza, G., Hinojosa, L.M., Guadarrama, R., Florentino, R., Mohar, A., Meléndez, J., Maldonado, V., Chanona, J., Robles, E., De la Garza, J. Ann. Oncol. (2001) [Pubmed]
  11. cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein. Negri, S., Oberson, A., Steinmann, M., Sauser, C., Nicod, P., Waeber, G., Schorderet, D.F., Bonny, C. Genomics (2000) [Pubmed]
  12. Cervical cancer diagnosed shortly after pregnancy: prognostic variables and delivery routes. Sood, A.K., Sorosky, J.I., Mayr, N., Anderson, B., Buller, R.E., Niebyl, J. Obstetrics and gynecology. (2000) [Pubmed]
  13. Body mass predicts the survival of patients with new International Federation of Gynecology and Obstetrics Stage IB1 and IB2 cervical carcinoma treated with radical hysterectomy. Finan, M.A., Hoffman, M.S., Chambers, R., Fiorica, J.V., DeCesare, S., Kline, R.C., Roberts, W.S., Cavanagh, D. Cancer (1998) [Pubmed]
  14. A pilot study of neoadjuvant chemotherapy with mitomycin C, etoposide, cisplatin, and epirubicin for adenocarcinoma of the cervix. Tabata, T., Nishiura, K., Yanoh, K., Okugawa, T., Obata, H., Tanaka, K., Toyoda, N. Int. J. Clin. Oncol. (2004) [Pubmed]
  15. Cervical cancer in pregnant women: laparoscopic evaluation before delaying treatment. Stan, C., Megevand, E., Irion, O., Wang, C., Bruchim, I., Petignat, P. Eur. J. Gynaecol. Oncol. (2005) [Pubmed]
  16. Stage IB1 vs IB2 carcinoma of the cervix: should the new FIGO staging system define therapy? Grigsby, P.W. Gynecol. Oncol. (1996) [Pubmed]
  17. Correlation between the treated volume, the GTV and the CTV at the time of brachytherapy and the histopathologic findings in 33 patients with operable cervix carcinoma. Muschitz, S., Petrow, P., Briot, E., Petit, C., De Crevoisier, R., Duvillard, P., Morice, P., Haie-Meder, C. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2004) [Pubmed]
  18. Sentinel node identification in cervical cancer patients undergoing transperitoneal radical hysterectomy: a study of 100 cases. Wydra, D., Sawicki, S., Wojtylak, S., Bandurski, T., Emerich, J. Int. J. Gynecol. Cancer (2006) [Pubmed]
  19. A pilot study of perilymphatic leukocyte cytokine mixture (IRX-2) as neoadjuvant treatment for early stage cervical carcinoma. Dueñas-Gonzalez, A., Verastegui, E., Lopez-Graniel, C., Gonzalez, A., Mota, A., Barrera-Franco, J.L., Meneses, A., Chanona, J., de la Garza, J., Chavez-Blanco, A., Hadden, J.W. Int. Immunopharmacol. (2002) [Pubmed]
  20. Type III radical hysterectomy after induction chemotherapy for patients with locally advanced cervical carcinoma. Lopez-Graniel, C., Reyes, M., Chanona, G., Gonzalez, A., Robles, E., Mohar, A., Lopez-Basave, H., De La Garza, J.G., Dueñas-Gonzalez, A. Int. J. Gynecol. Cancer (2001) [Pubmed]
  21. Concomitant irradiation and dose-escalating carboplatin for locally advanced carcinoma of the uterine cervix: an updated report. Corn, B.W., Micaily, B., Dunton, C.J., Heller, P., Valicenti, R.K., Anderson, L., Hernandez, E. Am. J. Clin. Oncol. (1998) [Pubmed]
  22. Sentinel node biopsy is reliable in early-stage cervical cancer but not in locally advanced disease. Barranger, E., Coutant, C., Cortez, A., Uzan, S., Darai, E. Ann. Oncol. (2005) [Pubmed]
  23. Operable Stages IB and II cervical carcinomas: a retrospective study comparing preoperative uterovaginal brachytherapy and postoperative radiotherapy. Atlan, D., Touboul, E., Deniaud-Alexandre, E., Lefranc, J.P., Antoine, J.M., Jannet, D., Lhuillier, P., Uzan, M., Huart, J., Genestie, C., Antoine, M., Jamali, M., Ganansia, V., Milliez, J., Uzan, S., Blondon, J. Int. J. Radiat. Oncol. Biol. Phys. (2002) [Pubmed]
  24. A comparison of stages IB1 and IB2 cervical cancers treated with radical hysterectomy. Is size the real difference? Rutledge, T.L., Kamelle, S.A., Tillmanns, T.D., Gould, N.S., Wright, J.D., Cohn, D.E., Herzog, T.J., Rader, J.S., Gold, M.A., Johnson, G.A., Walker, J.L., Mannel, R.S., McMeekin, D.S. Gynecol. Oncol. (2004) [Pubmed]
  25. Clinicopathological features influencing pelvic lymph node metastasis and vaginal and parametrial involvement in patients with carcinoma of the cervix. Silva-Filho, A.L., Reis, F.M., Traiman, P., Pedrosa, M.S., Miranda, D., Triginelli, S.A. Gynecol. Obstet. Invest. (2005) [Pubmed]
  26. Laparoscopy versus laparotomy for pelvic and lombo-aortic lymphadenectomy. A 11-year experience. Socolov, R.V., Raudrantz, D., Golfier, F., Socolov, D., Vaudoyer, F. Revista medico-chirurgical¿ a Societ¿¿ii de Medici ¿i Naturali¿ti din Ia¿i. (2005) [Pubmed]
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