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Chemical Compound Review

Zinc sulfate     zinc sulfate

Synonyms: Medizinc, Zincomed, Bonazen, Goslarite, Optised, ...
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Disease relevance of Zinc sulfate


Psychiatry related information on Zinc sulfate


High impact information on Zinc sulfate


Chemical compound and disease context of Zinc sulfate


Biological context of Zinc sulfate


Anatomical context of Zinc sulfate

  • (ii) Zinc, copper, manganese, or nickel sulfate administered in equimolar amounts under the same regimen did not induce viral reactivation; however, zinc sulfate in molar ratios 25-fold greater than those of cadmium induced viral replication in 2 of 16 ganglia tested [26].
  • When normal and SV40-transformed human tumor cells are plated and grown in medium containing zinc sulfate, a significant fraction of the transformed cells fail to grow at zinc concentrations which are relatively nontoxic to the normal fibroblasts [27].
  • Biocytin application to the normal or zinc sulfate-treated nasal cavity of Xenopus laevis was used to trace retrogradely neurons associated with the terminal nerve (TN) [28].
  • Response of olfactory Schwann cells to intranasal zinc sulfate irrigation [29].
  • Destruction of the receptors in the main olfactory system with zinc sulfate eliminated the increase in fos immunoreactivity in the amygdala, bed nucleus of the stria terminalis and preoptic area following exposure to sexually stimulating pheromones [30].

Associations of Zinc sulfate with other chemical compounds


Gene context of Zinc sulfate


Analytical, diagnostic and therapeutic context of Zinc sulfate

  • Children aged 2-23 mo (n = 299) who were hospitalized with severe pneumonia were randomly assigned to receive 10-mg tablets of zinc sulfate or placebo twice a day during hospitalization, along with standard therapy for severe pneumonia [41].
  • The mechanisms of the previously described competitive zinc:iron interaction were explored in healthy human volunteers, using the increment in plasma zinc concentration after an oral dose of 25 mg of zinc as zinc sulfate as the index of zinc absorption [42].
  • A modified zinc sulfate flotation technique using Formalinized fecal specimens (F-ZnSO4) was compared to the Formalin-ether (FE) concentration method for the laboratory diagnosis of intestinal parasites [43].
  • In other offspring subjected to either unilateral nephrectomy or orchidectomy, induction of ATase activity by zinc sulfate was also seen in kidney (5.7- and 8.4-fold) and testis (1.7- and 3.1-fold), although these observations were made with small numbers of mice.(ABSTRACT TRUNCATED AT 400 WORDS)[44]
  • We therefore tested the effect of chronic oral administration of zinc sulfate (0.075 and 0.375 g/kg) on disease onset and survival of mSOD1 transgenic mice [45].


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  19. Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice. Satoh, M., Shimada, A., Zhang, B., Tohyama, C. Biochem. Pharmacol. (2000) [Pubmed]
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  21. Drug resistance and gene amplification potential regulated by transforming growth factor beta 1 gene expression. Huang, A., Jin, H., Wright, J.A. Cancer Res. (1995) [Pubmed]
  22. Bioavailability of zinc from zinc-histidine complexes. I. Comparison with zinc sulfate in healthy men. Schölmerich, J., Freudemann, A., Köttgen, E., Wietholtz, H., Steiert, B., Löhle, E., Häussinger, D., Gerok, W. Am. J. Clin. Nutr. (1987) [Pubmed]
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  25. Zinc deficiency affects neither platelet arachidonic acid metabolism nor platelet aggregation in rats. Hwang, D.H., Chanmugam, P., Wheeler, C. J. Nutr. (1984) [Pubmed]
  26. Induction of reactivation of herpes simplex virus in murine sensory ganglia in vivo by cadmium. Fawl, R.L., Roizman, B. J. Virol. (1993) [Pubmed]
  27. SV40-transformed human cells fail to grow in zinc concentrations which permit normal human fibroblast proliferation. Epstein, J. J. Cell. Physiol. (1982) [Pubmed]
  28. A subpopulation of nervus terminalis neurons projects to the olfactory mucosa in Xenopus laevis. Koza, J.M., Wirsig-Wiechmann, C.R. J. Neurosci. Res. (2001) [Pubmed]
  29. Response of olfactory Schwann cells to intranasal zinc sulfate irrigation. Chuah, M.I., Tennent, R., Jacobs, I. J. Neurosci. Res. (1995) [Pubmed]
  30. The main olfactory system mediates pheromone-induced fos expression in the extended amygdala and preoptic area of the male Syrian hamster. Swann, J., Rahaman, F., Bijak, T., Fiber, J. Neuroscience (2001) [Pubmed]
  31. A reference method for measurement of alkaline phosphatase activity in human serum. Tietz, N.W., Burtis, C.A., Duncan, P., Ervin, K., Petitclerc, C.J., Rinker, A.D., Shuey, D., Zygowicz, E.R. Clin. Chem. (1983) [Pubmed]
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  33. Effect of three concentration techniques on viability of Cryptosporidium parvum oocysts recovered from bovine feces. Bukhari, Z., Smith, H.V. J. Clin. Microbiol. (1995) [Pubmed]
  34. Zinc enhancement of 17beta-estradiol's anabolic effect in osteoblastic MC3T3-E1 cells. Yamaguchi, M., Matsui, T. Calcif. Tissue Int. (1997) [Pubmed]
  35. Effect of zinc-chelating dipeptides on osteoblastic MC3T3-E1 cells: activation of aminoacyl-tRNA synthetase. Yamaguchi, M., Kishi, S., Hashizume, M. Peptides (1994) [Pubmed]
  36. C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration. Ebisch, I.M., van Heerde, W.L., Thomas, C.M., van der Put, N., Wong, W.Y., Steegers-Theunissen, R.P. Fertil. Steril. (2003) [Pubmed]
  37. Receptor activator of NF-kappaB ligand-stimulated osteoclastogenesis in mouse marrow culture is suppressed by zinc in vitro. Yamaguchi, M., Uchiyama, S. Int. J. Mol. Med. (2004) [Pubmed]
  38. Effects of parathyroid hormone on plasma zinc concentration in rat with chronic renal failure. Chen, S.M., Kuo, C.D., Liao, J.F., Ho, L.T. The Chinese journal of physiology. (2005) [Pubmed]
  39. Odorant deprivation reversibly modulates transsynaptic changes in the NR2B-mediated CREB pathway in mouse piriform cortex. Kim, H.H., Puche, A.C., Margolis, F.L. J. Neurosci. (2006) [Pubmed]
  40. Methods in pathology. Optimization of proliferating cell nuclear antigen immunohistochemical staining by microwave heating in zinc sulfate solution. Shin, H.J., Shin, D.M., Shah, T., Ro, J.Y. Mod. Pathol. (1994) [Pubmed]
  41. Efficacy of zinc in the treatment of severe pneumonia in hospitalized children <2 y old. Bose, A., Coles, C.L., Gunavathi, n.u.l.l., John, H., Moses, P., Raghupathy, P., Kirubakaran, C., Black, R.E., Brooks, W.A., Santosham, M. Am. J. Clin. Nutr. (2006) [Pubmed]
  42. Studies on the bioavailability of zinc in humans: mechanism of the intestinal interaction of nonheme iron and zinc. Solomons, N.W., Pineda, O., Viteri, F., Sandstead, H.H. J. Nutr. (1983) [Pubmed]
  43. Comparative evaluation of a modified zinc sulfate flotation technique. Bartlett, M.S., Harper, K., Smith, N., Verbanac, P., Smith, J.W. J. Clin. Microbiol. (1978) [Pubmed]
  44. Tissue-specific expression and induction of human O6-alkylguanine-DNA alkyltransferase in transgenic mice. Rafferty, J.A., Fan, C.Y., Potter, P.M., Watson, A.J., Cawkwell, L., O'Connor, P.J., Margison, G.P. Mol. Carcinog. (1992) [Pubmed]
  45. Zinc amplifies mSOD1-mediated toxicity in a transgenic mouse model of amyotrophic lateral sclerosis. Groeneveld, G.J., de Leeuw van Weenen, J., van Muiswinkel, F.L., Veldman, H., Veldink, J.H., Wokke, J.H., Bär, P.R., van den Berg, L.H. Neurosci. Lett. (2003) [Pubmed]
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