Gene Review:
Gp6 - glycoprotein 6 (platelet)
Mus musculus
Synonyms:
9830166G18Rik, GPVI, Glycoprotein 5, Gm469, Gpvi, ...
Cazenave,
Bobe,
Moroi,
Gachet,
Rackebrandt,
Eagleton,
Harrison,
Rhee,
Bergmeier,
Jung,
Siraganian,
Wonerow,
Nieswandt,
Senis,
Venkateswarlu,
Suzuki-Inoue,
Roberts,
Nakagaki,
Nagamatsu,
Cullen,
Okkenhaug,
Mokhtari-Nejad,
Pearce,
Green,
Miura,
Atkinson,
Watson,
Moroi,
Wilde,
Pearce,
Senis,
Zirngibl,
Turner,
Watson,
Schulte,
Andrews,
Jarvis,
Kawashima,
Watson,
Ohlmann,
Suzuki-Inoue,
Vigorito,
Inoue,
Auger,
Watson,
Best,
Vanhaesebroeck,
Dean,
Watson,
Maschberger,
Wilde,
Auger,
Frampton,
Jung,
Siess,
Ito,
Sekiya,
Saito,
Mizuguchi,
- Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents. Boylan, B., Berndt, M.C., Kahn, M.L., Newman, P.J. Blood (2006)
- GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism. Lockyer, S., Okuyama, K., Begum, S., Le, S., Sun, B., Watanabe, T., Matsumoto, Y., Yoshitake, M., Kambayashi, J., Tandon, N.N. Thromb. Res. (2006)
- GPVI levels in platelets: relationship to platelet function at high shear. Best, D., Senis, Y.A., Jarvis, G.E., Eagleton, H.J., Roberts, D.J., Saito, T., Jung, S.M., Moroi, M., Harrison, P., Green, F.R., Watson, S.P. Blood (2003)
- Platelets activated by collagen through the immunoreceptor tyrosine-based activation motif in the Fc receptor gamma-chain play a pivotal role in the development of myocardial ischemia-reperfusion injury. Takaya, N., Katoh, Y., Iwabuchi, K., Hayashi, I., Konishi, H., Itoh, S., Okumura, K., Ra, C., Nagaoka, I., Daida, H. J. Mol. Cell. Cardiol. (2005)
- Diverging signaling events control the pathway of GPVI down-regulation in vivo. Rabie, T., Varga-Szabo, D., Bender, M., Pozgaj, R., Lanza, F., Saito, T., Watson, S.P., Nieswandt, B. Blood (2007)
- The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice. Cheli, Y., Jensen, D., Marchese, P., Habart, D., Wiltshire, T., Cooke, M., Fernandez, J.A., Ware, J., Ruggeri, Z.M., Kunicki, T.J. Blood (2008)
- A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. Massberg, S., Gawaz, M., Grüner, S., Schulte, V., Konrad, I., Zohlnhöfer, D., Heinzmann, U., Nieswandt, B. J. Exp. Med. (2003)
- Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. Judd, B.A., Myung, P.S., Obergfell, A., Myers, E.E., Cheng, A.M., Watson, S.P., Pear, W.S., Allman, D., Shattil, S.J., Koretzky, G.A. J. Exp. Med. (2002)
- Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. Nieswandt, B., Schulte, V., Bergmeier, W., Mokhtari-Nejad, R., Rackebrandt, K., Cazenave, J.P., Ohlmann, P., Gachet, C., Zirngibl, H. J. Exp. Med. (2001)
- Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2. Inoue, O., Suzuki-Inoue, K., Dean, W.L., Frampton, J., Watson, S.P. J. Cell Biol. (2003)
- The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo. Munnix, I.C., Strehl, A., Kuijpers, M.J., Auger, J.M., van der Meijden, P.E., van Zandvoort, M.A., oude Egbrink, M.G., Nieswandt, B., Heemskerk, J.W. Arterioscler. Thromb. Vasc. Biol. (2005)
- Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. Kuijpers, M.J., Schulte, V., Bergmeier, W., Lindhout, T., Brakebusch, C., Offermanns, S., Fässler, R., Heemskerk, J.W., Nieswandt, B. FASEB J. (2003)
- Tec regulates platelet activation by GPVI in the absence of Btk. Atkinson, B.T., Ellmeier, W., Watson, S.P. Blood (2003)
- Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain. Bori-Sanz, T., Inoue, K.S., Berndt, M.C., Watson, S.P., Tulasne, D. J. Biol. Chem. (2003)
- Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets. Senis, Y.A., Atkinson, B.T., Pearce, A.C., Wonerow, P., Auger, J.M., Okkenhaug, K., Pearce, W., Vigorito, E., Vanhaesebroeck, B., Turner, M., Watson, S.P. Platelets (2005)
- Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Jandrot-Perrus, M., Busfield, S., Lagrue, A.H., Xiong, X., Debili, N., Chickering, T., Le Couedic, J.P., Goodearl, A., Dussault, B., Fraser, C., Vainchenker, W., Villeval, J.L. Blood (2000)
- Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Inoue, O., Suzuki-Inoue, K., McCarty, O.J., Moroi, M., Ruggeri, Z.M., Kunicki, T.J., Ozaki, Y., Watson, S.P. Blood (2006)
- A novel viper venom metalloproteinase, alborhagin, is an agonist at the platelet collagen receptor GPVI. Andrews, R.K., Gardiner, E.E., Asazuma, N., Berlanga, O., Tulasne, D., Nieswandt, B., Smith, A.I., Berndt, M.C., Watson, S.P. J. Biol. Chem. (2001)
- GPVI down-regulation in murine platelets through metalloproteinase-dependent shedding. Bergmeier, W., Rabie, T., Strehl, A., Piffath, C.L., Prostredna, M., Wagner, D.D., Nieswandt, B. Thromb. Haemost. (2004)
- A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets. Pasquet, J.M., Bobe, R., Gross, B., Gratacap, M.P., Tomlinson, M.G., Payrastre, B., Watson, S.P. Biochem. J. (1999)
- Lipid rafts orchestrate signaling by the platelet receptor glycoprotein VI. Locke, D., Chen, H., Liu, Y., Liu, C., Kahn, M.L. J. Biol. Chem. (2002)
- Phosphatidylinositol 3-kinase-dependent translocation of phospholipase Cgamma2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation. Bobe, R., Wilde, J.I., Maschberger, P., Venkateswarlu, K., Cullen, P.J., Siess, W., Watson, S.P. Blood (2001)
- Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites. Suzuki-Inoue, K., Wilde, J.I., Andrews, R.K., Auger, J.M., Siraganian, R.P., Sekiya, F., Rhee, S.G., Watson, S.P. Biochem. J. (2004)
- Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen. Leo, L., Di Paola, J., Judd, B.A., Koretzky, G.A., Lentz, S.R. Blood (2002)
- Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Quek, L.S., Pasquet, J.M., Hers, I., Cornall, R., Knight, G., Barnes, M., Hibbs, M.L., Dunn, A.R., Lowell, C.A., Watson, S.P. Blood (2000)
- Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation. Berlanga, O., Bobe, R., Becker, M., Murphy, G., Leduc, M., Bon, C., Barry, F.A., Gibbins, J.M., Garcia, P., Frampton, J., Watson, S.P. Blood (2000)
- A new monoclonal antibody, mAb 204-11, that influences the binding of platelet GPVI to fibrous collagen. Moroi, M., Mizuguchi, J., Kawashima, S., Nagamatsu, M., Miura, Y., Nakagaki, T., Ito, K., Jung, S.M. Thromb. Haemost. (2003)