Gene Review:
Pik3cd - phosphatidylinositol 3-kinase catalytic...
Mus musculus
Synonyms:
2410099E07Rik, 2610208K16Rik, AW545373, PI3-kinase subunit delta, PI3K-delta, ...
- Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading. Lakkakorpi, P.T., Wesolowski, G., Zimolo, Z., Rodan, G.A., Rodan, S.B. Exp. Cell Res. (1997)
- Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases. Thomas, M.J., Smith, A., Head, D.H., Milne, L., Nicholls, A., Pearce, W., Vanhaesebroeck, B., Wymann, M.P., Hirsch, E., Trifilieff, A., Walker, C., Finan, P., Westwick, J. Eur. J. Immunol. (2005)
- Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway. Philpott, N.J., Nociari, M., Elkon, K.B., Falck-Pedersen, E. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. Bilancio, A., Okkenhaug, K., Camps, M., Emery, J.L., Ruckle, T., Rommel, C., Vanhaesebroeck, B. Blood (2006)
- Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Kenney, A.M., Widlund, H.R., Rowitch, D.H. Development (2004)
- Vasopressin mediates neuroprotection in mice by stimulation of V1 vasopressin receptors: influence of PI-3 kinase and gap junction inhibitors. Tyagi, M.G., Parthiban, K.V. Indian J. Exp. Biol. (2003)
- A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Knight, Z.A., Gonzalez, B., Feldman, M.E., Zunder, E.R., Goldenberg, D.D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., Balla, T., Weiss, W.A., Williams, R.L., Shokat, K.M. Cell (2006)
- Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Fantl, W.J., Escobedo, J.A., Martin, G.A., Turck, C.W., del Rosario, M., McCormick, F., Williams, L.T. Cell (1992)
- Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta. Sawyer, C., Sturge, J., Bennett, D.C., O'Hare, M.J., Allen, W.E., Bain, J., Jones, G.E., Vanhaesebroeck, B. Cancer Res. (2003)
- Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: critical dimerization of inducible nitric-oxide synthase. Sakai, K., Suzuki, H., Oda, H., Akaike, T., Azuma, Y., Murakami, T., Sugi, K., Ito, T., Ichinose, H., Koyasu, S., Shirai, M. J. Biol. Chem. (2006)
- Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase. Jain, S.K., Langdon, W.Y., Varticovski, L. Oncogene (1997)
- The acute and chronic stimulatory effects of endothelin-1 on glucose transport are mediated by distinct pathways in 3T3-L1 adipocytes. Ishibashi, K., Imamura, T., Sharma, P.M., Ugi, S., Olefsky, J.M. Endocrinology (2000)
- PI 3-kinase p110beta: a new target for antithrombotic therapy. Jackson, S.P., Schoenwaelder, S.M., Goncalves, I., Nesbitt, W.S., Yap, C.L., Wright, C.E., Kenche, V., Anderson, K.E., Dopheide, S.M., Yuan, Y., Sturgeon, S.A., Prabaharan, H., Thompson, P.E., Smith, G.D., Shepherd, P.R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C., Lu, L., Giuliano, S., Hughan, S.C., Angus, J.A., Robertson, A.D., Salem, H.H. Nat. Med. (2005)
- P110delta, a novel phosphoinositide 3-kinase in leukocytes. Vanhaesebroeck, B., Welham, M.J., Kotani, K., Stein, R., Warne, P.H., Zvelebil, M.J., Higashi, K., Volinia, S., Downward, J., Waterfield, M.D. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages. Leverrier, Y., Okkenhaug, K., Sawyer, C., Bilancio, A., Vanhaesebroeck, B., Ridley, A.J. J. Biol. Chem. (2003)
- A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. Clayton, E., Bardi, G., Bell, S.E., Chantry, D., Downes, C.P., Gray, A., Humphries, L.A., Rawlings, D., Reynolds, H., Vigorito, E., Turner, M. J. Exp. Med. (2002)
- p110beta and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production. Smith, A.J., Surviladze, Z., Gaudet, E.A., Backer, J.M., Mitchell, C.A., Wilson, B.S. J. Biol. Chem. (2001)
- The role of endothelial PI3Kgamma activity in neutrophil trafficking. Puri, K.D., Doggett, T.A., Huang, C.Y., Douangpanya, J., Hayflick, J.S., Turner, M., Penninger, J., Diacovo, T.G. Blood (2005)
- Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase. Webb, L.M., Vigorito, E., Wymann, M.P., Hirsch, E., Turner, M. J. Immunol. (2005)
- Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets. Senis, Y.A., Atkinson, B.T., Pearce, A.C., Wonerow, P., Auger, J.M., Okkenhaug, K., Pearce, W., Vigorito, E., Vanhaesebroeck, B., Turner, M., Watson, S.P. Platelets (2005)
- The p110delta subunit of phosphoinositide 3-kinase is required for the lipopolysaccharide response of mouse B cells. Hebeis, B.J., Vigorito, E., Turner, M. Biochem. Soc. Trans. (2004)
- Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. Reif, K., Okkenhaug, K., Sasaki, T., Penninger, J.M., Vanhaesebroeck, B., Cyster, J.G. J. Immunol. (2004)
- Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue. Puri, K.D., Doggett, T.A., Douangpanya, J., Hou, Y., Tino, W.T., Wilson, T., Graf, T., Clayton, E., Turner, M., Hayflick, J.S., Diacovo, T.G. Blood (2004)
- A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction. Geng, L., Tan, J., Himmelfarb, E., Schueneman, A., Niermann, K., Brousal, J., Fu, A., Cuneo, K., Kesicki, E.A., Treiberg, J., Hayflick, J.S., Hallahan, D.E. Cancer Res. (2004)
- Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Okkenhaug, K., Bilancio, A., Farjot, G., Priddle, H., Sancho, S., Peskett, E., Pearce, W., Meek, S.E., Salpekar, A., Waterfield, M.D., Smith, A.J., Vanhaesebroeck, B. Science (2002)
- Selective role of PI3K delta in neutrophil inflammatory responses. Sadhu, C., Dick, K., Tino, W.T., Staunton, D.E. Biochem. Biophys. Res. Commun. (2003)
- Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury. Bonnans, C., Fukunaga, K., Keledjian, R., Petasis, N.A., Levy, B.D. J. Exp. Med. (2006)
- Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. Aksoy, I.A., Ramsey, M.J., Fruman, D.A., Aksoy, S., Cantley, L.C., Tucker, J.D., Roberts, T.M. Biochem. Biophys. Res. Commun. (1999)