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Gene Review

Eno1  -  enolase 1, (alpha)

Rattus norvegicus

Synonyms: 2-phospho-D-glycerate hydro-lyase, Alpha-enolase, Eno-1, Enolase 1, NNE, ...
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Disease relevance of Eno1


High impact information on Eno1


Biological context of Eno1


Anatomical context of Eno1


Associations of Eno1 with chemical compounds

  • Three forms of the glycolytic enzyme, enolase [2-phospho-D-glycerate hydrolase (E.C. No.] have been prepared from rat whole brain extract [18].
  • Following in vivo destruction of neurons by intracerebral injection of the selective neurotoxin, kainic acid, there was a significant decrease in the activity of NSE and hybrid enolase (neuronal forms) and no change in the activity of NNE (glial form) [19].
  • Identification of neuron-specific enolase and nonneuronal enolase in human and rat brain on two-dimensional polyacrylamide gels [20].
  • Neurone-specific enolase and creatine phosphokinase are protein components of rat brain synaptic plasma membranes [21].
  • The specific enzymatic activities of enolase and creatine phosphokinase, as well as of pyruvate kinase, also present on the membranes, were comparable to those in the homogenates when these three enzymes were fully activated [21].

Physical interactions of Eno1


Regulatory relationships of Eno1

  • On the other hand, levels of NSE subunit (gamma subunit or 14-3-2 protein) in adipose tissue (0.51 +/- 0.03 gamma gamma-equivalent pmol/mg protein) were increased to 170% of control by serial injection (for 7 days) of epinephrine or norepinephrine with little change of the level of enolase alpha subunit on a mg protein basis [22].
  • ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation [23].

Other interactions of Eno1


Analytical, diagnostic and therapeutic context of Eno1


  1. Enolase isozymes in differentiated and undifferentiated medullary thyroid carcinomas. Oskam, R., Rijksen, G., Lips, C.J., Staal, G.E. Cancer (1985) [Pubmed]
  2. Enzyme immunoassay of NSE and GFAP as the criterion of dynamic evaluation of the rat blood-brain barrier in perinatal hypoxic ischemic injury of the CNS. Chekhonin, V.P., Lebedev, S.V., Dmitrieva, T.B., Blinov, D.V., Gurina, O.I., Semenova, A.V., Volodin, N.N. Bull. Exp. Biol. Med. (2003) [Pubmed]
  3. Neuron-specific enolase as a marker of in vitro neuronal damage. Part I: Assessment of neuron-specific enolase as a quantitative and specific marker of neuronal damage. Hans, P., Bonhomme, V., Collette, J., Moonen, G. Journal of neurosurgical anesthesiology. (1993) [Pubmed]
  4. The etiology of toxic peripheral neuropathies: in vitro effects of acrylamide and 2,5-hexanedione on brain enolase and other glycolytic enzymes. Howland, R.D., Vyas, I.L., Lowndes, H.E., Argentieri, T.M. Brain Res. (1980) [Pubmed]
  5. Brain endolases as specific markers of neuronal and glial cells. Schmechel, D., Marangos, P.J., Zis, A.P., Brightman, M., Goodwin, F.K. Science (1978) [Pubmed]
  6. Angiotensin II activates pp60c-src in vascular smooth muscle cells. Ishida, M., Marrero, M.B., Schieffer, B., Ishida, T., Bernstein, K.E., Berk, B.C. Circ. Res. (1995) [Pubmed]
  7. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Jiang, B.H., Agani, F., Passaniti, A., Semenza, G.L. Cancer Res. (1997) [Pubmed]
  8. Cytotypic differences in the protein composition of the axonally transported cytoskeleton in mammalian neurons. Oblinger, M.M., Brady, S.T., McQuarrie, I.G., Lasek, R.J. J. Neurosci. (1987) [Pubmed]
  9. Molecular cloning and the nucleotide sequence of cDNA to mRNA for non-neuronal enolase (alpha alpha enolase) of rat brain and liver. Sakimura, K., Kushiya, E., Obinata, M., Takahashi, Y. Nucleic Acids Res. (1985) [Pubmed]
  10. Expression of the neuron-specific enolase gene by rat oligodendroglial cells during their differentiation. Deloulme, J.C., Lucas, M., Gaber, C., Bouillon, P., Keller, A., Eclancher, F., Sensenbrenner, M. J. Neurochem. (1996) [Pubmed]
  11. Plasminogen binds specifically to alpha-enolase on rat neuronal plasma membrane. Nakajima, K., Hamanoue, M., Takemoto, N., Hattori, T., Kato, K., Kohsaka, S. J. Neurochem. (1994) [Pubmed]
  12. Thyroid hormones differentially modulate enolase isozymes during rat skeletal and cardiac muscle development. Merkulova, T., Keller, A., Oliviero, P., Marotte, F., Samuel, J.L., Rappaport, L., Lamandé, N., Lucas, M. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  13. Expression of DNA sequences containing neuron specific enolase gene in Escherichia coli. Dutta, S.K., Bhattacharyya, N., Parui, R., Verma, M. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  14. Neurons switch from non-neuronal enolase to neuron-specific enolase during differentiation. Schmechel, D.E., Brightman, M.W., Marangos, P.J. Brain Res. (1980) [Pubmed]
  15. Neuron-specific enolase (NSE) and non-neuronal enolase (NNE) mRNAs are co-expressed in neurons of the rat cerebellum: in situ hybridization histochemistry. Katagiri, T., Feng, X., Ichikawa, T., Usui, H., Takahashi, Y., Kumanishi, T. Brain Res. Mol. Brain Res. (1993) [Pubmed]
  16. Changes in levels of translatable mRNA for neuron-specific enolase and non-neuronal enolase during development of rat brain and liver. Yoshida, Y., Sakimura, K., Masuda, T., Kushiya, E., Takahashi, Y. J. Biochem. (1983) [Pubmed]
  17. Neuron-specific enolase as an index of neuronal regeneration and reinnervation. Kirino, T., Brightman, M.W., Oertel, W.H., Schmechel, D.E., Marangos, P.J. J. Neurosci. (1983) [Pubmed]
  18. Neuronal, non-neuronal and hybrid forms of enolase in brain: structural, immunological and functional comparisons. Marangos, P.J., Zis, A.P., Clark, R.L., Goodwin, F.K. Brain Res. (1978) [Pubmed]
  19. Activity of neuron-specific enolase in normal and lesioned rat brain. Francis, A., Rivett, A.J., Roth, J.A. Brain Res. (1983) [Pubmed]
  20. Identification of neuron-specific enolase and nonneuronal enolase in human and rat brain on two-dimensional polyacrylamide gels. Heydorn, W.E., Creed, G.J., Marangos, P.J., Jacobowitz, D.M. J. Neurochem. (1985) [Pubmed]
  21. Neurone-specific enolase and creatine phosphokinase are protein components of rat brain synaptic plasma membranes. Lim, L., Hall, C., Leung, T., Mahadevan, L., Whatley, S. J. Neurochem. (1983) [Pubmed]
  22. Regulation of nervous system-specific S-100 protein and enolase levels in adipose tissue by catecholamines. Suzuki, F., Kato, K., Nakajima, T. J. Neurochem. (1984) [Pubmed]
  23. ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. Mizukami, Y., Iwamatsu, A., Aki, T., Kimura, M., Nakamura, K., Nao, T., Okusa, T., Matsuzaki, M., Yoshida, K., Kobayashi, S. J. Biol. Chem. (2004) [Pubmed]
  24. Differential expression of alpha- and beta-enolase genes during rat heart development and hypertrophy. Keller, A., Rouzeau, J.D., Farhadian, F., Wisnewsky, C., Marotte, F., Lamandé, N., Samuel, J.L., Schwartz, K., Lazar, M., Lucas, M. Am. J. Physiol. (1995) [Pubmed]
  25. Isolation of a potential neural stem cell line from the internal capsule of an adult transgenic rat brain. Kilty, I.C., Barraclough, R., Schmidt, G., Rudland, P.S. J. Neurochem. (1999) [Pubmed]
  26. Development of glial cells cultured from prenatally alcohol treated rat brain: effect of supplementation of the maternal alcohol diet with a grape extract. Ledig, M., Holownia, A., Copin, J.C., Tholey, G., Anokhina, I. Neurochem. Res. (1996) [Pubmed]
  27. Immunocytochemical localization and developmental profile of neuron specific enolase (NSE) and non-neuronal enolase (NNE) in aggregating cell cultures of fetal rat brain. Trapp, B.D., Marangos, P.J., Webster, H.D. Brain Res. (1981) [Pubmed]
  28. Effects of various forms of stimulation on the content of enolase isozymes and S-100 protein in superior cervical sympathetic ganglia excised from rats. Nagata, Y., Ando, M., Miwa, M., Kato, K. J. Neurochem. (1984) [Pubmed]
  29. Effects of denervation and axotomy on nervous system-specific protein, ornithine decarboxylase, and other enzyme activities in the superior cervical sympathetic ganglion of the rat. Ando, M., Miwa, M., Kato, K., Nagata, Y. J. Neurochem. (1984) [Pubmed]
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