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Gene Review

Narp  -  neuro activity regulated petaxin

Rattus norvegicus

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Disease relevance of Narp


High impact information on Narp


Biological context of Narp


Anatomical context of Narp

  • In contrast, labyrinth ablation did not affect Narp staining in Deiters' nucleus or the flocculonodular lobe of the cerebellum, presumably because these areas are driven by inputs from multiple systems [3].
  • Unexpectedly, we found robust Narp expression in several discrete areas linked to the vestibular system: the anterodorsal nucleus (ADN) of the thalamus, which relays head orientation information to the cortex, the lateral vestibulospinal (Deiters') nucleus and Purkinje cells in the flocculonodular lobe of the cerebellum [3].
  • The secretion of the neuronal activity-regulated pentraxin (Narp) by hippocampal axons is restricted to contacts with interneurons [7].
  • Opiate withdrawal induces Narp in the extended amygdala [4].
  • Use of the dnNarp mutants to suppress endogenous Narp expression by postsynaptic dendrites showed a complementary role for dendritic Narp in the clustering of synaptic AMPA receptors, as well as a reduction in the total number of excitatory synapses on transfected neurons [8].

Associations of Narp with chemical compounds


Other interactions of Narp


  1. Glomerular expression of neuronal activity-regulated pentraxin precedes the development of anti-Thy-1-induced progressive glomerulosclerosis. Aben, J.A., Ijpelaar, D.H., Baelde, H., Worley, P., Noble, N., Bruijn, J.A., de Heer, E. Kidney Int. (2006) [Pubmed]
  2. AGS-induced expression of Narp is concomitant with expression of AMPA receptor subunits GluR1 and GluR2 in hippocampus but not inferior colliculus of P77PMC rats. Li, S.Y., Xu, D.S., Jia, H.T. Neurobiol. Dis. (2003) [Pubmed]
  3. Prominent expression of Narp in central vestibular pathways: selective effect of labyrinth ablation. Reti, I.M., Minor, L.B., Baraban, J.M. Eur. J. Neurosci. (2002) [Pubmed]
  4. Opiate withdrawal induces Narp in the extended amygdala. Reti, I.M., Baraban, J.M. Neuropsychopharmacology (2003) [Pubmed]
  5. Sustained increase in Narp protein expression following repeated electroconvulsive seizure. Reti, I.M., Baraban, J.M. Neuropsychopharmacology (2000) [Pubmed]
  6. Effects of acute administration of methamphetamine on Narp mRNA in rat brain. Fukumoto, M., Iwata, M., Shinbori, C., Hazama, G.I., Shirayama, Y., Kawahara, R. Addiction biology. (2005) [Pubmed]
  7. Differing mechanisms for glutamate receptor aggregation on dendritic spines and shafts in cultured hippocampal neurons. Mi, R., Tang, X., Sutter, R., Xu, D., Worley, P., O'Brien, R.J. J. Neurosci. (2002) [Pubmed]
  8. Synaptically targeted narp plays an essential role in the aggregation of AMPA receptors at excitatory synapses in cultured spinal neurons. O'Brien, R., Xu, D., Mi, R., Tang, X., Hopf, C., Worley, P. J. Neurosci. (2002) [Pubmed]
  9. Selective expression of Narp, a secreted neuronal pentraxin, in orexin neurons. Reti, I.M., Reddy, R., Worley, P.F., Baraban, J.M. J. Neurochem. (2002) [Pubmed]
  10. Developmental changes in PSD-95 and Narp mRNAs in the rat olfactory bulb. Shu, F., Ohno, K., Wang, T., Kuriyama, K., Ueki, T., Kanayama, N., Sato, K. Brain Res. Dev. Brain Res. (2001) [Pubmed]
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