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Gene Review

Nptx2  -  neuronal pentraxin II

Rattus norvegicus

Synonyms: NP-II, NP2, Narp, Neuronal activity-regulated pentraxin, Neuronal pentraxin II, ...
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Disease relevance of Nptx2

  • Expression of NP-2 and PlxA2 mRNAs was evident in developing inner nuclear and ganglion cell layers at birth [1].
  • Pregnancy increased (p < 0.01) food intake, body weight, weight gain, and food efficiency ratio (P2 vs NP2 and P1 vs NP1, respectively), but the treatment of oil included in the diets did not alter these parameters [2].

Psychiatry related information on Nptx2

  • We also examined the possible role of Narp in individual differences in responding to a novel environment, a predictor of behavioural responses to psychomotor stimulant drugs including the propensity to acquire drug self-administration [3].
  • Narp levels in the PFC, but not other regions, were significantly correlated with locomotor activity in a novel environment [3].

High impact information on Nptx2

  • Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp [4].
  • Narp is shown to be selectively enriched at excitatory synapses on neurons from both the hippocampus and spinal cord [4].
  • Here, differential gene expression analysis using a rat complementary DNA micro array revealed neuronal activity-regulated pentraxin (Narp) as a candidate gene involved in the remodeling or progression of damaged glomeruli [5].
  • RT-PCR, western and immunocytochemical analyses revealed that oligodendrocytes expressed NP1, several alternatively spliced isoforms of NP2, and a broad spectrum of both soluble (Class 3), membrane-spanning (Class 4-6), and membrane-tethered (Class 7) semaphorin ligands [6].
  • In contrast, Narp expression in dendrites was minimal in these neuronal populations [7].

Chemical compound and disease context of Nptx2


Anatomical context of Nptx2


Associations of Nptx2 with chemical compounds


Other interactions of Nptx2


Analytical, diagnostic and therapeutic context of Nptx2

  • To study the effects of psychomotor stimulants, Narp levels were quantified by Western blotting and normalized to actin [3].


  1. Expression of class-3 semaphorins and their receptors in the neonatal and adult rat retina. de Winter, F., Cui, Q., Symons, N., Verhaagen, J., Harvey, A.R. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  2. Lipaemia and liver composition in pregnant rats consuming olive oil and olive oil used for frying. López-Varela, S., Sánchez-Muniz, F.J. Zeitschrift für Ernährungswissenschaft. (1997) [Pubmed]
  3. Amphetamine and cocaine do not increase Narp expression in rat ventral tegmental area, nucleus accumbens or prefrontal cortex, but Narp may contribute to individual differences in responding to a novel environment. Lu, W., Marinelli, M., Xu, D., Worley, P.F., Wolf, M.E. Eur. J. Neurosci. (2002) [Pubmed]
  4. Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. O'Brien, R.J., Xu, D., Petralia, R.S., Steward, O., Huganir, R.L., Worley, P. Neuron (1999) [Pubmed]
  5. Glomerular expression of neuronal activity-regulated pentraxin precedes the development of anti-Thy-1-induced progressive glomerulosclerosis. Aben, J.A., Ijpelaar, D.H., Baelde, H., Worley, P., Noble, N., Bruijn, J.A., de Heer, E. Kidney Int. (2006) [Pubmed]
  6. A role for semaphorins and neuropilins in oligodendrocyte guidance. Cohen, R.I., Rottkamp, D.M., Maric, D., Barker, J.L., Hudson, L.D. J. Neurochem. (2003) [Pubmed]
  7. Prominent Narp expression in projection pathways and terminal fields. Reti, I.M., Reddy, R., Worley, P.F., Baraban, J.M. J. Neurochem. (2002) [Pubmed]
  8. Characterization and chromosomal localization of PTP-NP-2, a new isoform of protein tyrosine phosphatase-like receptor, expressed on synaptic boutons. Jiang, S., Tulloch, A.G., Kim, T.A., Fu, Y., Rogers, R., Gaskell, A., White, R.A., Avraham, H., Avraham, S. Gene (1998) [Pubmed]
  9. Vasopressin-neurophysin II gene expression in the ovary: studies in Sprague-Dawley, Long-Evans and Brattleboro rats. Fuller, P.J., Clements, J.A., Tregear, G.W., Nikolaidis, I., Whitfeld, P.L., Funder, J.W. J. Endocrinol. (1985) [Pubmed]
  10. Identification by RT-PCR and immunolocalization of arginine vasopressin in rat pancreas. Méchaly, I., Macari, F., Laliberté, M.F., Lautier, C., Serrano, J.J., Cros, G., Grigorescu, F. Diabetes Metab. (1999) [Pubmed]
  11. Bovine neurophysin II has prolactin-releasing activity in the estradiol-primed male rat. Shin, S.H., Obonsawin, M.C. Neuroendocrinology (1985) [Pubmed]
  12. Developmental changes in PSD-95 and Narp mRNAs in the rat olfactory bulb. Shu, F., Ohno, K., Wang, T., Kuriyama, K., Ueki, T., Kanayama, N., Sato, K. Brain Res. Dev. Brain Res. (2001) [Pubmed]
  13. Effects of acute administration of methamphetamine on Narp mRNA in rat brain. Fukumoto, M., Iwata, M., Shinbori, C., Hazama, G.I., Shirayama, Y., Kawahara, R. Addiction biology. (2005) [Pubmed]
  14. Differing mechanisms for glutamate receptor aggregation on dendritic spines and shafts in cultured hippocampal neurons. Mi, R., Tang, X., Sutter, R., Xu, D., Worley, P., O'Brien, R.J. J. Neurosci. (2002) [Pubmed]
  15. Selective expression of Narp, a secreted neuronal pentraxin, in orexin neurons. Reti, I.M., Reddy, R., Worley, P.F., Baraban, J.M. J. Neurochem. (2002) [Pubmed]
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