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Gene Review

WWTR1  -  WW domain containing transcription...

Homo sapiens

Synonyms: DKFZp586I1419, TAZ, Transcriptional coactivator with PDZ-binding motif, WW domain-containing transcription regulator protein 1
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Disease relevance of WWTR1

  • Mutations in the human TAZ gene are associated with Barth Syndrome, an often fatal X-linked disorder that presents with cardiomyopathy and neutropenia [1].
  • Of 204 patients suspected of having VAP and randomized to a treatment arm of the study, 127 (64%) had bacteriologically confirmed infections, of which 37% were polymicrobial and 32% involved Pseudomonas aeruginosa; 115 patients (51 TAZ and 64 CAZ recipients) remained evaluable as per protocol [2].
  • SETTING: The study was carried out in the CAPD unit of Assaf Harofeh Medical Center, Zerifin, Israel. PATIENTS AND METHODS: Six patients participated in the study, 4 had pseudomonas peritonitis, all were given an IP loading dose of 4 g/0.5 g PIP/TAZ [3].
  • The broad-spectrum of this formulation, together with its low degree of organ toxicity observed in adults, makes PIP/TAZ a tempting choice for children with radio-/chemotherapy-induced neutropenia [4].
  • The combination of piperacillin with tazobactam (PIP/TAZ) extends the activity of piperacillin against gram-positive, gram-negative, and anaerobic bacteria [4].

High impact information on WWTR1


Biological context of WWTR1


Anatomical context of WWTR1

  • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation [12].
  • The tolerability of PIP/TAZ was assessed in 19 children and adolescents between 2 and 18 years of age who developed a fever during aplasia after high dose radio-/chemotherapy and autologous stem cell transplantation (HD-SCT) for primary multifocal or relapsed solid tumours [4].
  • Using RT-PCR, we characterized TAZ mRNAs in cultured lymphocytes from nine subjects with Barth syndrome and two healthy controls [13].

Associations of WWTR1 with chemical compounds

  • For patients experiencing bacterial eradication, the rates of clinical change for cefmenoxime and CIP or TAZ treatment were similar (P = 0.77) [8].
  • Loss of E(2) binding ability appears irreversible, since we failed to label receptor accumulated under OH-Tam with [(3)H]E(2) or [(3)H]tamoxifen aziridine (TAZ) [14].
  • Tazobactam could not be detected in the plasma of most patients and the therapeutic implications of IP administration of TAZ cannot be directly correlated to intravenous administration [3].

Regulatory relationships of WWTR1


Other interactions of WWTR1


Analytical, diagnostic and therapeutic context of WWTR1

  • This cream (TAZ) was applied for four consecutive days to human volunteers on the same 24-cm2 application area on the forearm for 12 h under occlusion [16].


  1. Mitochondrial respiratory chain supercomplexes are destabilized in Barth Syndrome patients. McKenzie, M., Lazarou, M., Thorburn, D.R., Ryan, M.T. J. Mol. Biol. (2006) [Pubmed]
  2. Treatment of ventilator-associated pneumonia with piperacillin-tazobactam/amikacin versus ceftazidime/amikacin: a multicenter, randomized controlled trial. VAP Study Group. Brun-Buisson, C., Sollet, J.P., Schweich, H., Brière, S., Petit, C. Clin. Infect. Dis. (1998) [Pubmed]
  3. Pharmacokinetics of intraperitoneal piperacillin/tazobactam in patients on peritoneal dialysis with and without pseudomonas peritonitis. Zaidenstein, R., Weissgarten, J., Dishi, V., Koren, M., Soback, S., Gips, M., Averbuch, Z., Simantov, R., Assulin, E., Golik, A. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (2000) [Pubmed]
  4. Tolerability of piperacillin/tazobactam in children and adolescents after high dose radio-/chemotherapy and autologous stem cell transplantation. Nürnberger, W., Bönig, H., Burdach, S., Göbel, U. Infection (1998) [Pubmed]
  5. ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins. Ponting, C.P., Blake, D.J., Davies, K.E., Kendrick-Jones, J., Winder, S.J. Trends Biochem. Sci. (1996) [Pubmed]
  6. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. Kanai, F., Marignani, P.A., Sarbassova, D., Yagi, R., Hall, R.A., Donowitz, M., Hisaminato, A., Fujiwara, T., Ito, Y., Cantley, L.C., Yaffe, M.B. EMBO J. (2000) [Pubmed]
  7. Neutrophils in Barth syndrome (BTHS) avidly bind annexin-V in the absence of apoptosis. Kuijpers, T.W., Maianski, N.A., Tool, A.T., Becker, K., Plecko, B., Valianpour, F., Wanders, R.J., Pereira, R., Van Hove, J., Verhoeven, A.J., Roos, D., Baas, F., Barth, P.G. Blood (2004) [Pubmed]
  8. Modeling the response of pneumonia to antimicrobial therapy. Hyatt, J.M., Luzier, A.B., Forrest, A., Ballow, C.H., Schentag, J.J. Antimicrob. Agents Chemother. (1997) [Pubmed]
  9. Barth syndrome presenting with acute metabolic decompensation in the neonatal period. Donati, M.A., Malvagia, S., Pasquini, E., Morrone, A., Marca, G.L., Garavaglia, B., Toniolo, D., Zammarchi, E. J. Inherit. Metab. Dis. (2006) [Pubmed]
  10. TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation. Hong, J.H., Yaffe, M.B. Cell Cycle (2006) [Pubmed]
  11. A novel family of Ca2+/calmodulin-binding proteins involved in transcriptional regulation: interaction with fsh/Ring3 class transcription activators. Du, L., Poovaiah, B.W. Plant Mol. Biol. (2004) [Pubmed]
  12. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Hong, J.H., Hwang, E.S., McManus, M.T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B.M., Sharp, P.A., Hopkins, N., Yaffe, M.B. Science (2005) [Pubmed]
  13. Barth syndrome: TAZ gene mutations, mRNAs, and evolution. Gonzalez, I.L. Am. J. Med. Genet. A (2005) [Pubmed]
  14. Evidence of an estrogen receptor form devoid of estrogen binding ability in MCF-7 cells. El Khissiin, A., Journé, F., Laïos, I., Seo, H.S., Leclercq, G. Steroids (2000) [Pubmed]
  15. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. Zhang, H., Liu, C.Y., Zha, Z.Y., Zhao, B., Yao, J., Zhao, S., Xiong, Y., Lei, Q.Y., Guan, K.L. J. Biol. Chem. (2009) [Pubmed]
  16. Percutaneous absorption, metabolic profiling, and excretion of the penetration enhancer azone after multiple dosing of an azone-containing triamcinolone acetonide cream in humans. Wiechers, J.W., Drenth, B.F., Jonkman, J.H., de Zeeuw, R.A. Journal of pharmaceutical sciences. (1990) [Pubmed]
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