The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SYF2  -  SYF2 pre-mRNA-splicing factor

Homo sapiens

Synonyms: CBPIN, CCNDBP1-interactor, DKFZp564O2082, GCIPIP, NTC31, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SYF2


High impact information on SYF2

  • Antisera have been prepared against the separated glycoprotein chains (p29 and p34) of HLA-DR antigens (p29,34) isolated from membranes of the B lymphoblastoid cell line JY (DRw4,6) [5].
  • Anti-p29 and anti-p34 specifically immunoprecipitated the precursors to p29 and p34, respectively, from the cell-free translation products of a rabbit reticulocyte lysate system supplemented with polyadenylic acid-containing messenger RNA (mRNA) isolated from JY cells [5].
  • Utilizing a multielectrode array to record spontaneous and visually evoked activity of cortical neurons in area 17, we investigate the relationship between long-range correlated spontaneous activity and functional ocular dominance columns during early ferret postnatal development (P24-P29) [6].
  • Nucleotide sequence analysis indicated that p29 and p40 were encoded by a single large open reading frame [7].
  • Examination of the p29 amino acid sequence revealed similarity to the Potyvirus-encoded cysteine-type proteinase HC-Pro [7].

Biological context of SYF2

  • The coding regions for p29 and p40 were mapped to nonoverlapping portions of the 5'- and 3'-terminal domains of the open reading frame, respectively [7].
  • The p29 cleavage product was also detected during T-cell receptor-mediated apoptosis in peripheral blood lymphocytes from normal donors [8].
  • Gene expression by a viral-like double-stranded RNA genetic element associated with reduced virulence (hypovirulence) of the chestnut blight fungus was recently shown to involve an autoproteolytic event which resulted in the release of an encoded protease, designated p29, from a polyprotein during translation [9].
  • In normal tissue p29 was present throughout the ectocervix during the menstrual cycle and virtually absent from the endocervix [10].

Anatomical context of SYF2

  • The transient expression of HA-tagged p29 in HeLa cells localized in the nucleus [11].
  • Multiple tissue Northern blot analysis showed that p29 was abundantly expressed in the heart, skeletal muscle, and kidney relative to other tissues [11].
  • With the exception of the previously identified p29 protein, the pattern of detectably altered protein synthesis during glucocorticoid treatment was identical in both cell lines [12].
  • This p29 cleaved fragment was detected in Jurkat cells induced to apoptose by anti-Fas antibody, staurosporin, or VP-16 [8].
  • The HLA-linked B cell alloantigen (p29,34) is composed of two subunits of 29,000 (p29) and 34,000 (p34) molecular weight [13].

Associations of SYF2 with chemical compounds

  • In sodium dodecyl sulfate at 21 degrees, p29 and p34 remained noncovalently associated and retained immunologic activity; subunit dissociation at higher temperatures correlated with loss of immunologic activity [13].
  • A 29-kDa serine protease (p29 or proteinase 3) and myeloperoxidase are the two best characterized antigens recognized by ANCA [1].
  • Seventy-three primary human breast cancers were analyzed to assess the presence of estrogen and progesterone receptors, the p29 protein, and the total cathepsin D status [14].
  • Tumours expressing ER (by either steroid binding assay or EIA) had higher levels of p29 than those which did not express the receptor (P < 0.0001) [15].
  • Moreover, tumours co-expressing ER, PR and p29 appeared to have higher levels of cathepsin D than those which were negative for at least one protein (P < 0.0001) [15].

Other interactions of SYF2

  • p29, a novel GCIP-interacting protein, localizes in the nucleus [11].

Analytical, diagnostic and therapeutic context of SYF2


  1. Antigen-specific radioimmunoassays for anti-neutrophil cytoplasmic antibodies in the diagnosis of rapidly progressive glomerulonephritis. Niles, J.L., Pan, G.L., Collins, A.B., Shannon, T., Skates, S., Fienberg, R., Arnaout, M.A., McCluskey, R.T. J. Am. Soc. Nephrol. (1991) [Pubmed]
  2. Production of human cloned antibodies specific for hepatitis D virus-encoded small and large protein. Liu, F., Roggendorf, M., Rasshofer, R., Zachoval, R., Deinhardt, F. J. Hepatol. (1993) [Pubmed]
  3. The prognostic value of the monoclonal antibody (D5) detected protein, p29, in primary colorectal carcinoma. Robertson, J.F., Morris, D.L., Ellis, I.O., Armitage, N.C., Hardcastle, J.D. Br. J. Cancer (1991) [Pubmed]
  4. Immunological evidence for the identity between the hsp27 estrogen-regulated heat shock protein and the p29 estrogen receptor-associated protein in breast and endometrial cancer. Ciocca, D.R., Luque, E.H. Breast Cancer Res. Treat. (1991) [Pubmed]
  5. Cell-free synthesis and processing of the heavy and light chains of HLA-DR antigens. Korman, A.J., Ploegh, H.L., Kaufman, J.F., Owen, M.J., Strominger, J.L. J. Exp. Med. (1980) [Pubmed]
  6. Relationship of correlated spontaneous activity to functional ocular dominance columns in the developing visual cortex. Chiu, C., Weliky, M. Neuron (2002) [Pubmed]
  7. Cotranslational autoproteolysis involved in gene expression from a double-stranded RNA genetic element associated with hypovirulence of the chestnut blight fungus. Choi, G.H., Shapira, R., Nuss, D.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  8. Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis. Johnson, D.E., Gastman, B.R., Wieckowski, E., Wang, G.Q., Amoscato, A., Delach, S.M., Rabinowich, H. Cancer Res. (2000) [Pubmed]
  9. The autocatalytic protease p29 encoded by a hypovirulence-associated virus of the chestnut blight fungus resembles the potyvirus-encoded protease HC-Pro. Choi, G.H., Pawlyk, D.M., Nuss, D.L. Virology (1991) [Pubmed]
  10. Immunohistochemical study of cytoplasmic oestradiol receptor in normal, dysplastic and malignant cervical tissue. Henry, R.J., Goodman, J.D., Godley, M., Raju, K.S., Coffer, A.I., King, R.J. British journal of obstetrics and gynaecology. (1988) [Pubmed]
  11. p29, a novel GCIP-interacting protein, localizes in the nucleus. Chang, M.S., Chang, C.L., Huang, C.J., Yang, Y.C. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  12. Selective loss of glucocorticoid-dependent responses in a variant of the DDT1MF-2 tumor cell line. Hendry, W.J., Hakkak, R., Cornett, L.E. Cancer Res. (1992) [Pubmed]
  13. Purification of HLA-linked B lymphocyte alloantigens in immunologically active form by preparative sodium dodecyl sulfate-gel electrophoresis and studies on their subunit association. Springer, T.A., Kaufman, J.F., Siddoway, L.A., Mann, D.L., Strominger, J.L. J. Biol. Chem. (1977) [Pubmed]
  14. Relation of cathepsin D level to the estrogen receptor in human breast cancer. Marsigliante, S., Biscozzo, L., Greco, S., Leo, G., Storelli, C. Int. J. Clin. Lab. Res. (1992) [Pubmed]
  15. Transcriptionally active non-ligand binding oestrogen receptors in breast cancer. Marsigliante, S., Greco, S., Biscozzo, L., Barker, S., Baker, V., Giuseppe, L., Vinson, G.P., Storelli, C. Cancer Lett. (1992) [Pubmed]
  16. Isolation and characterization of S-layer proteins from a vent prosthecate bacterium. Shen, N., Weiner, R.M. Microbios (1998) [Pubmed]
  17. p29 protein in breast cancer: relation between estrogen and progesterone receptors. Artero Morà, A., Lluch Hernandez, A., Cano Sanchez, A., Bueno Cañigral, F.J., Martin Quetglas, G., Alberola Candel, V., Garcia-Conde Bru, J. Tumori. (1989) [Pubmed]
WikiGenes - Universities