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Gene Review

LATS2  -  large tumor suppressor kinase 2

Homo sapiens

Synonyms: KPM, Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 2, Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase kpm, ...
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Disease relevance of LATS2


High impact information on LATS2

  • Nocodazole, a microtubule poison that provokes centrosome/mitotic apparatus dysfunction, induces Lats2 translocation from centrosomes to the nucleus and p53 accumulation [6].
  • Abrogation of Lats2 promotes accumulation of polyploid cells upon exposure to nocodazole, which can be prevented by direct activation of p53 [6].
  • We describe the importance of Lats2 (Large Tumor Suppressor 2) in this checkpoint response [6].
  • A value of 1.3 times 10-minus 4 M at 25 degrees, pH 7.80, T/2 0.33 for the equilibrium constant (KPMP) for dissociation of pyridoxamine-P from D-serine apodehydratase was determined from the ratio of the equilibrium constant for dissociation of pyridoxal-P from holoenzyme to KX [7].
  • The mechanism of LATS2-mediated repression of AR activity appears to involve the inhibition of AR NH2- and COOH-terminal interaction [2].

Biological context of LATS2


Anatomical context of LATS2


Associations of LATS2 with chemical compounds

  • This investigation showed that the KPM residues in H2O and the SFKPM residues in DMSO exhibited an extended backbone conformation, whereas a twisted conformation was found in this region in TFE [10].

Regulatory relationships of LATS2


Other interactions of LATS2


Analytical, diagnostic and therapeutic context of LATS2


  1. Lats2, a putative tumor suppressor, inhibits G1/S transition. Li, Y., Pei, J., Xia, H., Ke, H., Wang, H., Tao, W. Oncogene (2003) [Pubmed]
  2. The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. Powzaniuk, M., McElwee-Witmer, S., Vogel, R.L., Hayami, T., Rutledge, S.J., Chen, F., Harada, S., Schmidt, A., Rodan, G.A., Freedman, L.P., Bai, C. Mol. Endocrinol. (2004) [Pubmed]
  3. Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Takahashi, Y., Miyoshi, Y., Takahata, C., Irahara, N., Taguchi, T., Tamaki, Y., Noguchi, S. Clin. Cancer Res. (2005) [Pubmed]
  4. Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia. Jiménez-Velasco, A., Román-Gómez, J., Agirre, X., Barrios, M., Navarro, G., Vázquez, I., Prósper, F., Torres, A., Heiniger, A. Leukemia (2005) [Pubmed]
  5. Frequent polymorphic changes but rare tumor specific mutations of the LATS2 gene on 13q11-12 in esophageal squamous cell carcinoma. Ishizaki, K., Fujimoto, J., Kumimoto, H., Nishimoto, Y., Shimada, Y., Shinoda, M., Yamamoto, T. Int. J. Oncol. (2002) [Pubmed]
  6. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Aylon, Y., Michael, D., Shmueli, A., Yabuta, N., Nojima, H., Oren, M. Genes Dev. (2006) [Pubmed]
  7. Separation and evaluation of the covalent and noncovalent interactions which contribute to the binding of pyridoxal 5'-phosphate to D-serine apodehydratase. Schonbeck, N.D., Skalski, M., Shafer, J.A. J. Biol. Chem. (1975) [Pubmed]
  8. LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. Abe, Y., Ohsugi, M., Haraguchi, K., Fujimoto, J., Yamamoto, T. FEBS Lett. (2006) [Pubmed]
  9. Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). Ke, H., Pei, J., Ni, Z., Xia, H., Qi, H., Woods, T., Kelekar, A., Tao, W. Exp. Cell Res. (2004) [Pubmed]
  10. Determination of structural elements related to the biological activities of a potent decapeptide agonist of human C5a anaphylatoxin. Vogen, S.M., Prakash, O., Kirnarsky, L., Sanderson, S.D., Sherman, S.A. J. Pept. Res. (1999) [Pubmed]
  11. The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Toji, S., Yabuta, N., Hosomi, T., Nishihara, S., Kobayashi, T., Suzuki, S., Tamai, K., Nojima, H. Genes Cells (2004) [Pubmed]
  12. Identifying a region of interest in site- and stage-specific colon cancer on chromosome 13. Sivarajasingham, N.S., Baker, R., Tilsed, J.V., Greenman, J., Monson, J.R., Cawkwell, L. Ann. Surg. Oncol. (2003) [Pubmed]
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