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Gene Review

PPARG  -  peroxisome proliferator-activated receptor...

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High impact information on PPARG


Biological context of PPARG


Anatomical context of PPARG


Associations of PPARG with chemical compounds


Enzymatic interactions of PPARG

  • This study shows that both PPAR-alpha (Wy 14643) and PPAR-gamma activation (rosiglitazone) partially inhibit oxidized LDL-induced protein kinase C activity and endothelin-1 secretion in endothelial cells at the transcriptional levels and suggests that synthetic PPAR activators are stronger PPAR activators than oxidized LDL [15].

Regulatory relationships of PPARG


Other interactions of PPARG


Analytical, diagnostic and therapeutic context of PPARG


  1. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Liu, Y., Zhang, Y., Schmelzer, K., Lee, T.S., Fang, X., Zhu, Y., Spector, A.A., Gill, S., Morisseau, C., Hammock, B.D., Shyy, J.Y. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. King, F.J., Hu, E., Harris, D.F., Sarraf, P., Spiegelman, B.M., Roberts, T.M. Mol. Cell. Biol. (1999) [Pubmed]
  3. Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma. Cuzzocrea, S., Mazzon, E., Dugo, L., Patel, N.S., Serraino, I., Di Paola, R., Genovese, T., Britti, D., De Maio, M., Caputi, A.P., Thiemermann, C. Arthritis Rheum. (2003) [Pubmed]
  4. Angiogenesis and morphometry of bovine placentas in late gestation from embryos produced in vivo or in vitro. Miles, J.R., Farin, C.E., Rodriguez, K.F., Alexander, J.E., Farin, P.W. Biol. Reprod. (2004) [Pubmed]
  5. Characterisation of bovine peroxisome proliferator-activated receptors gamma 1 and gamma 2: genetic mapping and differential expression of the two isoforms. Sundvold, H., Brzozowska, A., Lien, S. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  6. Relationship between different stages of the corpus luteum and the expression of the peroxisome proliferator-activated receptor gamma protein in bovine large lutein cells. Viergutz, T., Loehrke, B., Poehland, R., Becker, F., Kanitz, W. J. Reprod. Fertil. (2000) [Pubmed]
  7. Changes in mRNA expression of regulatory factors involved in adipocyte differentiation during fatty acid induced adipogenesis in chicken. Matsubara, Y., Sato, K., Ishii, H., Akiba, Y. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2005) [Pubmed]
  8. Troglitazone reverses the inhibition of nitric oxide production by high glucose in cultured bovine retinal pericytes. Kim, J., Oh, Y.S., Shinn, S.H. Exp. Eye Res. (2005) [Pubmed]
  9. Regulation of differentiation of sheep subcutaneous and abdominal preadipocytes in culture. Soret, B., Lee, H.J., Finley, E., Lee, S.C., Vernon, R.G. J. Endocrinol. (1999) [Pubmed]
  10. Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma. Kanata, S., Akagi, M., Nishimura, S., Hayakawa, S., Yoshida, K., Sawamura, T., Munakata, H., Hamanishi, C. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  11. The interaction between vitamin A and thiazolidinedione on bovine adipocyte differentiation in primary culture. Ohyama, M., Matsuda, K., Torii, S., Matsui, T., Yano, H., Kawada, T., Ishihara, T. J. Anim. Sci. (1998) [Pubmed]
  12. Enhancing effect of troglitazone on porcine adipocyte differentiation in primary culture: a comparison with dexamethasone. Tchoukalova, Y.D., Hausman, D.B., Dean, R.G., Hausman, G.J. Obes. Res. (2000) [Pubmed]
  13. Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe. Colca, J.R., McDonald, W.G., Waldon, D.J., Leone, J.W., Lull, J.M., Bannow, C.A., Lund, E.T., Mathews, W.R. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  14. Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells. Löhrke, B., Viergutz, T., Shahi, S.K., Pöhland, R., Wollenhaupt, K., Goldammer, T., Walzel, H., Kanitz, W. J. Endocrinol. (1998) [Pubmed]
  15. Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells. Martin-Nizard, F., Furman, C., Delerive, P., Kandoussi, A., Fruchart, J.C., Staels, B., Duriez, P. J. Cardiovasc. Pharmacol. (2002) [Pubmed]
  16. Physical and genetic mapping of bovine CEBPA and PPARG genes. Ihara, N., Yamakuchi, H., Hirano, T., Takeda, H., Taniguchi, Y., Sasaki, Y., Davis, S.K., Taylor, J.F., Barendse, W., Sugimoto, Y. Anim. Genet. (1998) [Pubmed]
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