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Gene Review

DAOA  -  D-amino acid oxidase activator

Homo sapiens

Synonyms: G72, LG72, Protein G72, SG72
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Disease relevance of DAOA


Psychiatry related information on DAOA


High impact information on DAOA

  • DESIGN: A systematic study of polymorphisms at DAOA/G30 using genetic case-control association analysis [6].
  • CONTEXT: Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association [6].
  • Analysis of the decay of haplotype sharing gave a location estimate that included G72/G30 in its 95% confidence interval [7].
  • Recently, genes called "G72" and "G30" were identified, and polymorphisms of these overlapping genes were reported to be associated with schizophrenia [7].
  • Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia [8].

Chemical compound and disease context of DAOA

  • As yet, there is no widely-accepted genetic association finding in mood disorders, but functional candidate genes, such as the serotonin transporter, and positional candidates, such as G72/G30 on chromosome 13q, are beginning to be identified in several studies [9].

Biological context of DAOA


Anatomical context of DAOA


Associations of DAOA with chemical compounds

  • The interaction of G72 with d-amino acid oxidase, itself of interest as a modulator of N-methyl-d-aspartate receptors through regulation of d-serine levels, has been reported in one study and could be a key functional link that deserves further investigation [14].
  • Although an association of genes for D-serine degradation, such as D-amino acid oxidase and G72, has been reported, a role for D-serine in SZ has been unclear [15].
  • We newly generated monoclonal antibodies (mAbs) G152 and G72 directed against 6-sulfo sialyl Lewis X, which intensely labeled HEV in immunohistochemical examination and inhibited binding of recombinant L-selectin-IgG to HEV, suggesting that the determinant serves as a ligand for L-selectin [16].
  • The subjects were given 10 mg oral nisoldipine with water (control), or 5 mg oral nisoldipine with 200 mL grapefruit juice (G0) or with water at 14 (G14), 38 (G38), 72 (G72) or 96 hours (G96) after a 7-day period of thrice-daily intake of grapefruit juice [17].

Physical interactions of DAOA

  • The G72/G30 gene complex and cognitive abnormalities in schizophrenia [12].

Other interactions of DAOA

  • Interestingly, whereas the NRG1 gene analysis was dominated by the presence of over-transmitted haplotypes, the G72 gene analysis was consistently dominated in both datasets by under-transmissions [18].
  • On the basis of corrected P-values from single- and multilocus transmission distortion tests our analysis provides no support for a contribution of G72, NRG1 or DTNBP1 in the tested samples [18].
  • The evidence for COMT, RGS4 and G72 is promising but not yet persuasive [19].
  • The evidence for catechol-O-methyl transferase, RGS4 and G72 is promising but not yet persuasive [20].
  • Several regions of interest have emerged in linkage studies and, recently, evidence implicating specific genes has been reported; the best supported include BDNF and DAOA but further replications are required and phenotypic relationships and biological mechanisms need investigation [21].

Analytical, diagnostic and therapeutic context of DAOA

  • G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis [14].
  • Genetic variations in G72/G30 have been reported to be associated with schizophrenia and bipolar disorders in several case-control studies [22].
  • Compared with the control group, the maximum plasma concentration of nisoldipine was significantly increased after grapefruit juice intake in G0 and G14, and the plasma concentration was significantly increased at each time in G0 to G72 [17].
  • An analysis of chimeric tRNA(Pro) constructs showed that, in addition to A73 and G72, transplantation of the E. coli tRNA(Pro) D-domain was necessary and sufficient to convert the human tRNA into a substrate for the bacterial synthetase [23].


  1. The discriminator base influences tRNA structure at the end of the acceptor stem and possibly its interaction with proteins. Lee, C.P., Mandal, N., Dyson, M.R., RajBhandary, U.L. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes. Schulze, T.G., Ohlraun, S., Czerski, P.M., Schumacher, J., Kassem, L., Deschner, M., Gross, M., Tullius, M., Heidmann, V., Kovalenko, S., Jamra, R.A., Becker, T., Leszczynska-Rodziewicz, A., Hauser, J., Illig, T., Klopp, N., Wellek, S., Cichon, S., Henn, F.A., McMahon, F.J., Maier, W., Propping, P., Nöthen, M.M., Rietschel, M. The American journal of psychiatry. (2005) [Pubmed]
  3. Investigation of the DAOA/G30 locus in panic disorder. Schumacher, J., Abou Jamra, R., Becker, T., Klopp, N., Franke, P., Jacob, C., Sand, P., Fritze, J., Ohlraun, S., Schulze, T.G., Rietschel, M., Illig, T., Propping, P., Cichon, S., Deckert, J., Nöthen, M.M. Mol. Psychiatry (2005) [Pubmed]
  4. Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects. Yue, W., Kang, G., Zhang, Y., Qu, M., Tang, F., Han, Y., Ruan, Y., Lu, T., Zhang, J., Zhang, D. Neurosci. Lett. (2007) [Pubmed]
  5. Sleep disturbances in childhood-onset schizophrenia. Mattai, A.A., Tossell, J., Greenstein, D.K., Addington, A., Clasen, L.S., Gornick, M.C., Seal, J., Inoff-Germain, G., Gochman, P.A., Lenane, M., Rapoport, J.L., Gogtay, N. Schizophr. Res. (2006) [Pubmed]
  6. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Williams, N.M., Green, E.K., Macgregor, S., Dwyer, S., Norton, N., Williams, H., Raybould, R., Grozeva, D., Hamshere, M., Zammit, S., Jones, L., Cardno, A., Kirov, G., Jones, I., O'Donovan, M.C., Owen, M.J., Craddock, N. Arch. Gen. Psychiatry (2006) [Pubmed]
  7. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Hattori, E., Liu, C., Badner, J.A., Bonner, T.I., Christian, S.L., Maheshwari, M., Detera-Wadleigh, S.D., Gibbs, R.A., Gershon, E.S. Am. J. Hum. Genet. (2003) [Pubmed]
  8. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Chumakov, I., Blumenfeld, M., Guerassimenko, O., Cavarec, L., Palicio, M., Abderrahim, H., Bougueleret, L., Barry, C., Tanaka, H., La Rosa, P., Puech, A., Tahri, N., Cohen-Akenine, A., Delabrosse, S., Lissarrague, S., Picard, F.P., Maurice, K., Essioux, L., Millasseau, P., Grel, P., Debailleul, V., Simon, A.M., Caterina, D., Dufaure, I., Malekzadeh, K., Belova, M., Luan, J.J., Bouillot, M., Sambucy, J.L., Primas, G., Saumier, M., Boubkiri, N., Martin-Saumier, S., Nasroune, M., Peixoto, H., Delaye, A., Pinchot, V., Bastucci, M., Guillou, S., Chevillon, M., Sainz-Fuertes, R., Meguenni, S., Aurich-Costa, J., Cherif, D., Gimalac, A., Van Duijn, C., Gauvreau, D., Ouellette, G., Fortier, I., Raelson, J., Sherbatich, T., Riazanskaia, N., Rogaev, E., Raeymaekers, P., Aerssens, J., Konings, F., Luyten, W., Macciardi, F., Sham, P.C., Straub, R.E., Weinberger, D.R., Cohen, N., Cohen, D., Ouelette, G., Realson, J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Genetic association studies in mood disorders: issues and promise. Detera-Wadleigh, S.D., McMahon, F.J. International review of psychiatry (Abingdon, England) (2004) [Pubmed]
  10. Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Schumacher, J., Jamra, R.A., Freudenberg, J., Becker, T., Ohlraun, S., Otte, A.C., Tullius, M., Kovalenko, S., Bogaert, A.V., Maier, W., Rietschel, M., Propping, P., Nöthen, M.M., Cichon, S. Mol. Psychiatry (2004) [Pubmed]
  11. Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. Korostishevsky, M., Kaganovich, M., Cholostoy, A., Ashkenazi, M., Ratner, Y., Dahary, D., Bernstein, J., Bening-Abu-Shach, U., Ben-Asher, E., Lancet, D., Ritsner, M., Navon, R. Biol. Psychiatry (2004) [Pubmed]
  12. The G72/G30 gene complex and cognitive abnormalities in schizophrenia. Goldberg, T.E., Straub, R.E., Callicott, J.H., Hariri, A., Mattay, V.S., Bigelow, L., Coppola, R., Egan, M.F., Weinberger, D.R. Neuropsychopharmacology (2006) [Pubmed]
  13. Molecular Cloning and Characterization of a Novel 3'-Phosphoadenosine 5'-Phosphosulfate Transporter, PAPST2. Kamiyama, S., Sasaki, N., Goda, E., Ui-Tei, K., Saigo, K., Narimatsu, H., Jigami, Y., Kannagi, R., Irimura, T., Nishihara, S. J. Biol. Chem. (2006) [Pubmed]
  14. G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. Detera-Wadleigh, S.D., McMahon, F.J. Biol. Psychiatry (2006) [Pubmed]
  15. Serine racemase binds to PICK1: potential relevance to schizophrenia. Fujii, K., Maeda, K., Hikida, T., Mustafa, A.K., Balkissoon, R., Xia, J., Yamada, T., Ozeki, Y., Kawahara, R., Okawa, M., Huganir, R.L., Ujike, H., Snyder, S.H., Sawa, A. Mol. Psychiatry (2006) [Pubmed]
  16. Identification of a major carbohydrate capping group of the L-selectin ligand on high endothelial venules in human lymph nodes as 6-sulfo sialyl Lewis X. Mitsuoka, C., Sawada-Kasugai, M., Ando-Furui, K., Izawa, M., Nakanishi, H., Nakamura, S., Ishida, H., Kiso, M., Kannagi, R. J. Biol. Chem. (1998) [Pubmed]
  17. Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects. Takanaga, H., Ohnishi, A., Murakami, H., Matsuo, H., Higuchi, S., Urae, A., Irie, S., Furuie, H., Matsukuma, K., Kimura, M., Kawano, K., Orii, Y., Tanaka, T., Sawada, Y. Clin. Pharmacol. Ther. (2000) [Pubmed]
  18. The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations. Hall, D., Gogos, J.A., Karayiorgou, M. Genes Brain Behav. (2004) [Pubmed]
  19. Recent advances in the genetics of schizophrenia. O'Donovan, M.C., Williams, N.M., Owen, M.J. Hum. Mol. Genet. (2003) [Pubmed]
  20. The molecular genetics of schizophrenia: new findings promise new insights. Owen, M.J., Williams, N.M., O'Donovan, M.C. Mol. Psychiatry (2004) [Pubmed]
  21. Genetics of affective (mood) disorders. Craddock, N., Forty, L. Eur. J. Hum. Genet. (2006) [Pubmed]
  22. Family-based association study between G72/G30 genetic polymorphism and schizophrenia. Hong, C.J., Hou, S.J., Yen, F.C., Liou, Y.J., Tsai, S.J. Neuroreport (2006) [Pubmed]
  23. Evolutionary coadaptation of the motif 2--acceptor stem interaction in the class II prolyl-tRNA synthetase system. Burke, B., Yang, F., Chen, F., Stehlin, C., Chan, B., Musier-Forsyth, K. Biochemistry (2000) [Pubmed]
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