Disease relevance of DAOA

• Mutations of the discriminator base from adenosine to cytidine or uridine make the cytidine residue in the C1-G72 base pair of mutant Escherichia coli initiator tRNAs more reactive toward sodium bisulfite, the single-strand-specific reagent [1].

Psychiatry related information on DAOA

• Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes [2].
• The authors therefore tested for association between DAOA/G30 and bipolar affective disorder in the 90 cases with a history of persecutory delusions [2].
• Investigation of the DAOA/G30 locus in panic disorder [3].
• The association between the DAOA risk haplotype and clinical symptoms were examined by the positive and negative syndrome scale (PANSS) and the brief psychiatric rating scale (BPRS) [4].
• Comparisons between groups were made with respect to clinical ratings at both admission and during washout period, co-morbid diagnosis of generalized anxiety disorder (GAD) and a susceptibility gene (G72) for COS [5].

High impact information on DAOA

• DESIGN: A systematic study of polymorphisms at DAOA/G30 using genetic case-control association analysis [6].
• CONTEXT: Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association [6].
• Analysis of the decay of haplotype sharing gave a location estimate that included G72/G30 in its 95% confidence interval [7].
• Recently, genes called "G72" and "G30" were identified, and polymorphisms of these overlapping genes were reported to be associated with schizophrenia [7].
• Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia [8].

Chemical compound and disease context of DAOA

• As yet, there is no widely-accepted genetic association finding in mood disorders, but functional candidate genes, such as the serotonin transporter, and positional candidates, such as G72/G30 on chromosome 13q, are beginning to be identified in several studies [9].

Biological context of DAOA

• RESULTS: In a logistic regression, "persecutory delusions" were found to be the only significant explanatory variable for the DAOA/G30 risk genotype among 21 OPCRIT symptoms of psychosis [2].
• Given the presumed role of DAOA/G30 in the neurochemistry of psychosis and its localization in a schizophrenia and bipolar affective disorder linkage region (13q34), it was hypothesized that the bipolar affective disorder finding would be mainly due to an association with psychotic features [2].
• Two overlapping genes G72 and G30 transcribed in brain were experimentally annotated in this 65-kb region [8].
• Transfection experiments point to the existence of a 153-aa protein coded by the G72 gene [8].
• At G72, individual SNPs and a four-marker haplotype were associated with schizophrenia [10].

Anatomical context of DAOA

• Gene expression analysis of G72 and G30 was performed on 88 postmortem dorsolateral prefrontal cortex samples [11].
• In the fMRI paradigms, a strong effect of G72 SNP 10 genotype was observed on BOLD activation in the hippocampus during the episodic memory paradigm [12].
• The RNA interference of the PAPST2 gene in the HCT116 cells significantly reduced the reactivity of G72 antibody directed against the sialyl 6-sulfo N-acetyllactosamine epitope and total sulfate incorporation into cellular proteins [13].

Associations of DAOA with chemical compounds

• The interaction of G72 with d-amino acid oxidase, itself of interest as a modulator of N-methyl-d-aspartate receptors through regulation of d-serine levels, has been reported in one study and could be a key functional link that deserves further investigation [14].
• Although an association of genes for D-serine degradation, such as D-amino acid oxidase and G72, has been reported, a role for D-serine in SZ has been unclear [15].
• We newly generated monoclonal antibodies (mAbs) G152 and G72 directed against 6-sulfo sialyl Lewis X, which intensely labeled HEV in immunohistochemical examination and inhibited binding of recombinant L-selectin-IgG to HEV, suggesting that the determinant serves as a ligand for L-selectin [16].
• The subjects were given 10 mg oral nisoldipine with water (control), or 5 mg oral nisoldipine with 200 mL grapefruit juice (G0) or with water at 14 (G14), 38 (G38), 72 (G72) or 96 hours (G96) after a 7-day period of thrice-daily intake of grapefruit juice [17].

Physical interactions of DAOA

• The G72/G30 gene complex and cognitive abnormalities in schizophrenia [12].

Other interactions of DAOA

• Interestingly, whereas the NRG1 gene analysis was dominated by the presence of over-transmitted haplotypes, the G72 gene analysis was consistently dominated in both datasets by under-transmissions [18].
• On the basis of corrected P-values from single- and multilocus transmission distortion tests our analysis provides no support for a contribution of G72, NRG1 or DTNBP1 in the tested samples [18].
• The evidence for COMT, RGS4 and G72 is promising but not yet persuasive [19].
• The evidence for catechol-O-methyl transferase, RGS4 and G72 is promising but not yet persuasive [20].
• Several regions of interest have emerged in linkage studies and, recently, evidence implicating specific genes has been reported; the best supported include BDNF and DAOA but further replications are required and phenotypic relationships and biological mechanisms need investigation [21].

Analytical, diagnostic and therapeutic context of DAOA

• G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis [14].
• Genetic variations in G72/G30 have been reported to be associated with schizophrenia and bipolar disorders in several case-control studies [22].
• Compared with the control group, the maximum plasma concentration of nisoldipine was significantly increased after grapefruit juice intake in G0 and G14, and the plasma concentration was significantly increased at each time in G0 to G72 [17].
• An analysis of chimeric tRNA(Pro) constructs showed that, in addition to A73 and G72, transplantation of the E. coli tRNA(Pro) D-domain was necessary and sufficient to convert the human tRNA into a substrate for the bacterial synthetase [23].

References