Disease relevance of CAGE1

• Identification and characterization of a novel cancer/testis antigen gene CAGE-1 [1].
• PURPOSE: The aim of the study was to compare the prognostic value of a response by the Gynecologic Cancer Intergroup (GCIG) Cancer Antigen (CA) -125 response criteria and the Response Evaluation Criteria in Solid Tumors (RECIST) on survival in patients with ovarian carcinoma receiving second-line chemotherapy [2].
• Cancer antigen 125: tumor or serosal marker in case of ascites [3]?
• Cancer antigen 125 in patients with liver diseases [4].
• Cancer antigen 125: a sensitive marker of ascites in patients with liver cirrhosis [5].

High impact information on CAGE1

• The gene consisted of 556 bp, including an open reading frame consisted of 113 amino acids, designated as Kita-kyushu lung cancer antigen 1 (KK-LC-1) [6].
• Synthetic Control over Magnetic Moment and Exchange Bias in All-Oxide Materials Encapsulated within a Spherical Protein Cage [7].
• Interferon-inducible Mx1Cre mice were administered pT2F/Cage with or without transposase-encoding plasmid [8].
• Cancer antigen 125 in serum and ascitic fluid of patients with liver diseases [9].
• [structure: see text] Cage-type molecules composed of phenyl walls and caps were synthesized as hosts for the binding of ammonium and alkali metal cations through cation-pi interactions [10].

Chemical compound and disease context of CAGE1

• BACKGROUND: Cancer antigen (CA) 125 tumor-associated antigen is a high molecular glycoprotein used for follow-up of epithelial ovarian cancer [11].

Biological context of CAGE1

• Cancer antigen 125 associated with multiple benign and malignant pathologies [11].
• The importance of DNA hypermethylation in the conversion of TCC from a low to a high malignant potential was strongly supported by the finding that, unlike superficial low-grade TCC, advanced muscle invasive TCC showed a concurrent promoter methylation of the 14-3-3 sigma, SYK and CAGE-1 genes [12].
• According to the characteristics of the termini (5'-CHH ... CTAG-3') and a target site preference for T, this AT-rich minisatellite accompanying the flanking sequences was classified into a novel transposon, Basho [13].
• Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas [12].
• A Noninvasive, Cage-side Electrocardiogram and Blood Pressure Toxicology Screening Method for Beagles [14].

Anatomical context of CAGE1

• Cancer antigen (CA)125 is expressed by mesothelial cells (as by other coelomic epithelium-derived cells) and might therefore be considered a marker of the mesothelium [15].
• Cancer antigen 125 is produced by human endometrial stromal cells [16].
• Cancer antigen 125 is locally produced in the peritoneal cavity during continuous ambulatory peritoneal dialysis [17].
• INTERVENTION: Primary total hip arthroplasty supported by a reinforcement ring (Burch-Schneider Antiprotrusion Cage) and autologous bone grafting of the acetabulum [18].
• The classic: A Case of Absence of Cervical Vertebrae with the Thoracic Cage Rising to the Base of the Cranium (Cervical Thoracic Cage) [19].

Associations of CAGE1 with chemical compounds

• A Novel Cascade Supramolecular Complex with a Reversible Nanosized 18-Component H-Bonded {(C(6)H(6))(6)(SbF(6))(12)}(12)(-) Cage Unit Templated by a Chiral Metal-Organic Complex [20].
• The cages were composed of carbon fiber-reinforced polymer (Brantigan cage; DePuy AcroMed, Raynham, MA, n = 5) or titanium mesh (Harms Cage; DePuy AcroMed, Raynham, MA, n = 4) [21].
• Cancer antigen CA-50 and creatine kinase BB isoenzyme appeared to be of little diagnostic value [22].
• Cancer antigen (CA 125) is a glycoprotein commonly used as a tumor marker [23].
• Prediction of a Family of Cage-shaped Boric Acid Clusters [24].

Other interactions of CAGE1

• Cancer antigen 125, tissue polypeptide antigen, carcinoembryonic antigen, and beta-chain human chorionic gonadotropin as serum markers of epithelial ovarian carcinoma [25].

Analytical, diagnostic and therapeutic context of CAGE1

• Cancer antigen 125: a bulk marker for the mesothelial mass in stable peritoneal dialysis patients [15].
• The relevance of the high frequency of DNA hypermethylation of the CAGE-1 antigen in TCC and squamous cell carcinomas merits further study, particularly in relation to anticancer immunotherapy [12].
• OBJECT: Cage-assisted anterior cervical discectomy and fusion (ACDF) has proven to be a safe and effective procedure for the treatment of one- and two-level degenerative disc disease (DDD) [26].
• In the majority of patients, a tilting disk or a Cage ball prosthesis was implanted [27].
• SUMMARY OF BACKGROUND DATA: Cage design has been shown to influence loading of the augmented bone graft tissue [28].

References