Gene Review:
MAP4K1 - mitogen-activated protein kinase kinase...
Homo sapiens
Synonyms:
HPK1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, ...
- Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Shui, J.W., Boomer, J.S., Han, J., Xu, J., Dement, G.A., Zhou, G., Tan, T.H. Nat. Immunol. (2007)
- Synthesis of a novel inhibitor against MRSA and VRE: Preparation from zerumbone ring opening material showing histidine-kinase inhibition. Kitayama, T., Iwabuchi, R., Minagawa, S., Sawada, S., Okumura, R., Hoshino, K., Cappiello, J., Utsumi, R. Bioorg. Med. Chem. Lett. (2007)
- Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Hu, M.C., Qiu, W.R., Wang, X., Meyer, C.F., Tan, T.H. Genes Dev. (1996)
- HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Liou, J., Kiefer, F., Dang, A., Hashimoto, A., Cobb, M.H., Kurosaki, T., Weiss, A. Immunity (2000)
- Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade. Zhou, G., Lee, S.C., Yao, Z., Tan, T.H. J. Biol. Chem. (1999)
- Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1). Chen, Y.R., Meyer, C.F., Ahmed, B., Yao, Z., Tan, T.H. Oncogene (1999)
- Functional interactions of HPK1 with adaptor proteins. Boomer, J.S., Tan, T.H. J. Cell. Biochem. (2005)
- Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1. Arnold, R., Patzak, I.M., Neuhaus, B., Vancauwenbergh, S., Veillette, A., Van Lint, J., Kiefer, F. Mol. Cell. Biol. (2005)
- Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. Ling, P., Yao, Z., Meyer, C.F., Wang, X.S., Oehrl, W., Feller, S.M., Tan, T.H. Mol. Cell. Biol. (1999)
- Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. Sauer, K., Liou, J., Singh, S.B., Yablonski, D., Weiss, A., Perlmutter, R.M. J. Biol. Chem. (2001)
- Interaction of hematopoietic progenitor kinase 1 and c-Abl tyrosine kinase in response to genotoxic stress. Ito, Y., Pandey, P., Sathyanarayana, P., Ling, P., Rana, A., Weichselbaum, R., Tan, T.H., Kufe, D., Kharbanda, S. J. Biol. Chem. (2001)
- Synergistic regulation of immunoreceptor signaling by SLP-76-related adaptor Clnk and serine/threonine protein kinase HPK-1. Yu, J., Riou, C., Davidson, D., Minhas, R., Robson, J.D., Julius, M., Arnold, R., Kiefer, F., Veillette, A. Mol. Cell. Biol. (2001)
- Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. Zhou, G., Boomer, J.S., Tan, T.H. J. Biol. Chem. (2004)
- Hematopoietic progenitor kinase 1 (HPK1) negatively regulates prostaglandin E2-induced fos gene transcription. Sawasdikosol, S., Russo, K.M., Burakoff, S.J. Blood (2003)
- A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1. Ensenat, D., Yao, Z., Wang, X.S., Kori, R., Zhou, G., Lee, S.C., Tan, T.H. J. Biol. Chem. (1999)
- The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. Oehrl, W., Kardinal, C., Ruf, S., Adermann, K., Groffen, J., Feng, G.S., Blenis, J., Tan, T.H., Feller, S.M. Oncogene (1998)
- Activation of hematopoietic progenitor kinase-1 by erythropoietin. Nagata, Y., Kiefer, F., Watanabe, T., Todokoro, K. Blood (1999)
- Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. Ma, W., Xia, C., Ling, P., Qiu, M., Luo, Y., Tan, T.H., Liu, M. Oncogene (2001)
- Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. Yang, H.S., Matthews, C.P., Clair, T., Wang, Q., Baker, A.R., Li, C.C., Tan, T.H., Colburn, N.H. Mol. Cell. Biol. (2006)
- A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. Bartolo, V.D., Montagne, B., Salek, M., Jungwirth, B., Carrette, F., Fourtane, J., Sol-Foulon, N., Michel, F., Schwartz, O., Lehmann, W.D., Acuto, O. J. Exp. Med. (2007)
- B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1. Tsuji, S., Okamoto, M., Yamada, K., Okamoto, N., Goitsuka, R., Arnold, R., Kiefer, F., Kitamura, D. J. Exp. Med. (2001)
- Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix. Lewitzky, M., Harkiolaki, M., Domart, M.C., Jones, E.Y., Feller, S.M. J. Biol. Chem. (2004)