The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GRIK3  -  glutamate receptor, ionotropic, kainate 3

Homo sapiens

Synonyms: EAA5, Excitatory amino acid receptor 5, GLR7, GLUR7, GluK3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GRIK3


Psychiatry related information on GRIK3


High impact information on GRIK3


Biological context of GRIK3

  • Using three single nucleotide polymorphisms (SNP) in GRIK2 and one in GRIK3, we found no evidence for association in case-control or family-based analyses [3].
  • We also observed significant haplotype associations in seven SNP pairs in GRIK3 and in four SNP pairs in GRIK4 [9].
  • Genotype and allele distributions of GRIK3 T928G polymorphism in schizophrenics were similar to those of controls (p = 0.74 and p = 0.59, respectively) [10].
  • One compound, LU 97175, bound to native high affinity kainate receptors and rat GluR5-GluR7 subunits, i.e. low affinity kainate binding sites, with much higher affinities than to AMPA receptors [11].
  • Two variation of the EAA5 cDNA were identified which result in amino acid substitutions in the predicted extracellular amino-terminal region; Ser310-->Ala and Arg352-->Gln [12].

Anatomical context of GRIK3


Associations of GRIK3 with chemical compounds

  • We performed a case-control study in 156 patients and 141 controls and the transmission disequilibrium test in 124 parent-offspring trios to search for association between OCD and two kainate receptors, GRIK2 and GRIK3 [3].
  • Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence [15].
  • The human kainate receptor GluR7 gene contains a thymine (T)/guanine (G) nucleotide variation that determines a serine or alanine at position 310 in the extracellular region of GluR7 receptor subunits [16].

Regulatory relationships of GRIK3

  • Finally, we determined the C-terminal half of the L3 domain plus the far C-terminal domain of GluR7 to be responsible for the recently reported reduction of current amplitude seen when GluR7 is coexpressed with GluR6 [13].

Other interactions of GRIK3


Analytical, diagnostic and therapeutic context of GRIK3

  • GRIK3 functional polymorphism was determined using PCR [15].


  1. Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics. Preuss, U.W., Zill, P., Koller, G., Bondy, B., Hesselbrock, V., Soyka, M. Pharmacogenomics J. (2006) [Pubmed]
  2. Chromosomal localization of gene for human glutamate receptor subunit-7. Puranam, R.S., Eubanks, J.H., Heinemann, S.F., McNamara, J.O. Somat. Cell Mol. Genet. (1993) [Pubmed]
  3. Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder. Delorme, R., Krebs, M.O., Chabane, N., Roy, I., Millet, B., Mouren-Simeoni, M.C., Maier, W., Bourgeron, T., Leboyer, M. Neuroreport (2004) [Pubmed]
  4. Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder. Schiffer, H.H., Heinemann, S.F. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2007) [Pubmed]
  5. Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit. Bettler, B., Egebjerg, J., Sharma, G., Pecht, G., Hermans-Borgmeyer, I., Moll, C., Stevens, C.F., Heinemann, S. Neuron (1992) [Pubmed]
  6. PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. Perroy, J., El Far, O., Bertaso, F., Pin, J.P., Betz, H., Bockaert, J., Fagni, L. EMBO J. (2002) [Pubmed]
  7. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Mitsukawa, K., Yamamoto, R., Ofner, S., Nozulak, J., Pescott, O., Lukic, S., Stoehr, N., Mombereau, C., Kuhn, R., McAllister, K.H., van der Putten, H., Cryan, J.F., Flor, P.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Structure and pharmacological properties of a molluscan glutamate-gated cation channel and its likely role in feeding behavior. Stühmer, T., Amar, M., Harvey, R.J., Bermudez, I., van Minnen, J., Darlison, M.G. J. Neurosci. (1996) [Pubmed]
  9. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. Shibata, H., Aramaki, T., Sakai, M., Ninomiya, H., Tashiro, N., Iwata, N., Ozaki, N., Fukumaki, Y. Psychiatry research. (2006) [Pubmed]
  10. No association between the ionotropic glutamate receptor kainate 3 gene ser310ala polymorphism and schizophrenia. Lai, I.C., Liou, Y.J., Chen, J.Y., Wang, Y.C. Neuropsychobiology (2005) [Pubmed]
  11. A new pyrrolyl-quinoxalinedione series of non-NMDA glutamate receptor antagonists: pharmacological characterization and comparison with NBQX and valproate in the kindling model of epilepsy. Löscher, W., Lehmann, H., Behl, B., Seemann, D., Teschendorf, H.J., Hofmann, H.P., Lubisch, W., Höger, T., Lemaire, H.G., Gross, G. Eur. J. Neurosci. (1999) [Pubmed]
  12. Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites. Nutt, S.L., Hoo, K.H., Rampersad, V., Deverill, R.M., Elliott, C.E., Fletcher, E.J., Adams, S.L., Korczak, B., Foldes, R.L., Kamboj, R.K. Recept. Channels (1994) [Pubmed]
  13. Identification of domains and amino acids involved in GLuR7 ion channel function. Strutz, N., Villmann, C., Thalhammer, A., Kizelsztein, P., Eisenstein, M., Teichberg, V.I., Hollmann, M. J. Neurosci. (2001) [Pubmed]
  14. Time-dependent effect of kainate-induced seizures on glutamate receptor GluR5, GluR6, and GluR7 mRNA and Protein Expression in rat hippocampus. Ullal, G., Fahnestock, M., Racine, R. Epilepsia (2005) [Pubmed]
  15. Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence. Samochowiec, J., Grzywacz, A., Kucharska-Mazur, J., Samochowiec, A., Horodnicki, J., Pelka-Wysiecka, J., Syrek, S. Neurosci. Lett. (2006) [Pubmed]
  16. Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. Schiffer, H.H., Swanson, G.T., Masliah, E., Heinemann, S.F. J. Neurosci. (2000) [Pubmed]
  17. Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Swanson, G.T., Green, T., Heinemann, S.F. Mol. Pharmacol. (1998) [Pubmed]
  18. Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7). Schulz, H.L., Stohr, H., Weber, B.H. Neurosci. Lett. (2002) [Pubmed]
WikiGenes - Universities