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Gene Review

Arg2  -  arginase 2

Rattus norvegicus

Synonyms: Arginase-2, mitochondrial, Kidney-type arginase, Non-hepatic arginase, Type II arginase
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Disease relevance of Arg2

  • Reduction of arginase I in BDL livers may be responsible for the lowering of arginine levels in the plasma, while induction of arginase II could be important in regulating NO synthesis as well as other important mechanisms involved in liver cirrhosis [1].
  • These data demonstrate loss of constitutive expression of arginase II in rat lung as iNOS is upregulated by the response to sepsis [2].

High impact information on Arg2


Biological context of Arg2


Anatomical context of Arg2


Associations of Arg2 with chemical compounds


Regulatory relationships of Arg2


Other interactions of Arg2


Analytical, diagnostic and therapeutic context of Arg2


  1. Induction of arginase II in livers of bile duct-ligated rats. Wei, C.L., Hon, W.M., Lee, K.H., Mori, M., Gotoh, T., Khoo, H.E. Biochem. Pharmacol. (2002) [Pubmed]
  2. Differential expression of arginase and iNOS in the lung in sepsis. Carraway, M.S., Piantadosi, C.A., Jenkinson, C.P., Huang, Y.C. Exp. Lung Res. (1998) [Pubmed]
  3. The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver. Nissim, I., Luhovyy, B., Horyn, O., Daikhin, Y., Nissim, I., Yudkoff, M. J. Biol. Chem. (2005) [Pubmed]
  4. Prostate alpha-protein. Complete amino acid sequence of the component that inhibits nuclear retention of the androgen-receptor complex. Liao, S., Chen, C., Huang, I.Y. J. Biol. Chem. (1982) [Pubmed]
  5. Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II. Levillain, O., Hus-Citharel, A., Garvi, S., Peyrol, S., Reymond, I., Mutin, M., Morel, F. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  6. Role of the two N-terminal residues of angiotensin II in the production of tachyphylaxis. Miasiro, N., Oshiro, M.E., Paiva, T.B., Paiva, A.C. Eur. J. Pharmacol. (1983) [Pubmed]
  7. Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non-endocrine cell line, COS-7. Yanagita, M., Nakayama, K., Takeuchi, T. FEBS Lett. (1992) [Pubmed]
  8. Regional variations and age-related changes in nitric oxide synthase and arginase in the sub-regions of the hippocampus. Liu, P., Smith, P.F., Appleton, I., Darlington, C.L., Bilkey, D.K. Neuroscience (2003) [Pubmed]
  9. Expression of arginase II and related enzymes in the rat small intestine and kidney. Ozaki, M., Gotoh, T., Nagasaki, A., Miyanaka, K., Takeya, M., Fujiyama, S., Tomita, K., Mori, M. J. Biochem. (1999) [Pubmed]
  10. L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: an in situ hybridization study. Braissant, O., Gotoh, T., Loup, M., Mori, M., Bachmann, C. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  11. Glucocorticoids inhibit lipopolysaccharide-induced up-regulation of arginase in rat alveolar macrophages. Klasen, S., Hammermann, R., Fuhrmann, M., Lindemann, D., Beck, K.F., Pfeilschifter, J., Racké, K. Br. J. Pharmacol. (2001) [Pubmed]
  12. Nitric oxide synthase and arginase expression in the vestibular nucleus and hippocampus following unilateral vestibular deafferentation in the rat. Liu, P., Zheng, Y., King, J., Darlington, C.L., Smith, P.F. Brain Res. (2003) [Pubmed]
  13. Evaluation of nitric oxide synthase and arginase in the induction of a Peyronie's-like condition in the rat. Bivalacqua, T.J., Champion, H.C., Leungwattanakij, S., Yang, D.Y., Hyun, J.S., Abdel-Mageed, A.B., Sikka, S.C., Kadowitz, P.J., Hellstrom, W.J. J. Androl. (2001) [Pubmed]
  14. Synthesis and AT2 receptor-binding properties of angiotensin II analogues. Rosenström, U., Sköld, C., Lindeberg, G., Botros, M., Nyberg, F., Hallberg, A., Karlén, A. J. Pept. Res. (2004) [Pubmed]
  15. Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat. van Balkom, B.W., Hoffert, J.D., Chou, C.L., Knepper, M.A. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  16. Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats. Demougeot, C., Prigent-Tessier, A., Marie, C., Berthelot, A. J. Hypertens. (2005) [Pubmed]
  17. L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats. Schwartz, I.F., Schwartz, D., Traskonov, M., Chernichovsky, T., Wollman, Y., Gnessin, E., Topilsky, I., Levo, Y., Iaina, A. Kidney Int. (2002) [Pubmed]
  18. Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts. Lindemann, D., Racké, K. Naunyn Schmiedebergs Arch. Pharmacol. (2003) [Pubmed]
  19. Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production. Buga, G.M., Singh, R., Pervin, S., Rogers, N.E., Schmitz, D.A., Jenkinson, C.P., Cederbaum, S.D., Ignarro, L.J. Am. J. Physiol. (1996) [Pubmed]
  20. Mitochondrial expression of arginase II in male and female rat inner medullary collecting ducts. Levillain, O., Balvay, S., Peyrol, S. J. Histochem. Cytochem. (2005) [Pubmed]
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