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Gene Review

Apob  -  apolipoprotein B

Rattus norvegicus

Synonyms: Aa1064, Ac1-060, Apo B-100, ApoB-100, ApoB-48, ...
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Disease relevance of Apob


High impact information on Apob


Chemical compound and disease context of Apob


Biological context of Apob


Anatomical context of Apob


Associations of Apob with chemical compounds


Physical interactions of Apob


Enzymatic interactions of Apob


Regulatory relationships of Apob


Other interactions of Apob


Analytical, diagnostic and therapeutic context of Apob


  1. Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase. Sparks, J.D., Collins, H.L., Chirieac, D.V., Cianci, J., Jokinen, J., Sowden, M.P., Galloway, C.A., Sparks, C.E. Biochem. J. (2006) [Pubmed]
  2. HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia. Liang, J.S., Distler, O., Cooper, D.A., Jamil, H., Deckelbaum, R.J., Ginsberg, H.N., Sturley, S.L. Nat. Med. (2001) [Pubmed]
  3. Monomethylethanolamine reduces plasma triacylglycerols and apolipoprotein B and increases apolipoprotein A-I rats without induction of fatty liver. Rusiñol, A.E., Lysak, P.S., Sigurdson, G.T., Vance, J.E. J. Lipid Res. (1996) [Pubmed]
  4. Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins. Van't Hooft, F.M., Hardman, D.A., Kane, J.P., Havel, R.J. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  5. Lipoproteins accumulate in immune deposits and are modified by lipid peroxidation in passive Heymann nephritis. Exner, M., Susani, M., Witztum, J.L., Hovorka, A., Curtiss, L.K., Spitzauer, S., Kerjaschki, D. Am. J. Pathol. (1996) [Pubmed]
  6. An in vitro system for the editing of apolipoprotein B mRNA. Driscoll, D.M., Wynne, J.K., Wallis, S.C., Scott, J. Cell (1989) [Pubmed]
  7. Localization of apolipoprotein B in intestinal epithelial cells. Glickman, R.M., Khorana, J., Kilgore, A. Science (1976) [Pubmed]
  8. Oleate-mediated stimulation of apolipoprotein B secretion from rat hepatoma cells. A function of the ability of apolipoprotein B to direct lipoprotein assembly and escape presecretory degradation. White, A.L., Graham, D.L., LeGros, J., Pease, R.J., Scott, J. J. Biol. Chem. (1992) [Pubmed]
  9. Enteral administration of high-fat nutrition before and directly after hemorrhagic shock reduces endotoxemia and bacterial translocation. Luyer, M.D., Jacobs, J.A., Vreugdenhil, A.C., Hadfoune, M., Dejong, C.H., Buurman, W.A., Greve, J.W. Ann. Surg. (2004) [Pubmed]
  10. Age-related response to dietary fructose in the rat: discrepancy in triglyceride and apolipoprotein B synthesis as a possible mechanism for fatty liver induction in adult rats. Nassir, F., Mazur, A., Felgines, C., Rayssiguier, Y. Proc. Soc. Exp. Biol. Med. (1993) [Pubmed]
  11. Suppression of the protein tyrosine phosphatase LAR reduces apolipoprotein B secretion by McA-RH7777 rat hepatoma cells. Phung, T.L., Mooney, R.A., Kulas, D.T., Sparks, C.E., Sparks, J.D. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  12. Effects of vitamin E and vitamin C supplementation on plasma lipid peroxidation and on oxidation of apolipoprotein B-containing lipoproteins in experimental hyperthyroidism. Dirican, M., Taş, S. J. Med. Invest. (1999) [Pubmed]
  13. Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. Pan, M., Cederbaum, A.I., Zhang, Y.L., Ginsberg, H.N., Williams, K.J., Fisher, E.A. J. Clin. Invest. (2004) [Pubmed]
  14. Identification of novel alternative splice variants of APOBEC-1 complementation factor with different capacities to support apolipoprotein B mRNA editing. Sowden, M.P., Lehmann, D.M., Lin, X., Smith, C.O., Smith, H.C. J. Biol. Chem. (2004) [Pubmed]
  15. Apolipoprotein B messenger RNA editing in the rat liver. Modulation by fasting and refeeding a high carbohydrate diet. Baum, C.L., Teng, B.B., Davidson, N.O. J. Biol. Chem. (1990) [Pubmed]
  16. Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing. Blanc, V., Navaratnam, N., Henderson, J.O., Anant, S., Kennedy, S., Jarmuz, A., Scott, J., Davidson, N.O. J. Biol. Chem. (2001) [Pubmed]
  17. Coordinate regulation of lipogenesis, the assembly and secretion of apolipoprotein B-containing lipoproteins by sterol response element binding protein 1. Wang, S.L., Du, E.Z., Martin, T.D., Davis, R.A. J. Biol. Chem. (1997) [Pubmed]
  18. Developmental regulation of apolipoprotein B mRNA editing is an autonomous function of small intestine involving homeobox gene Cdx1. Patterson, A.P., Chen, Z., Rubin, D.C., Moucadel, V., Iovanna, J.L., Brewer, H.B., Eggerman, T.L. J. Biol. Chem. (2003) [Pubmed]
  19. Characterization of serum apolipoprotein patterns in rats during suckling and post-weaning periods. Imaizumi, K., Lu, Y.F., Sugano, M. Biochim. Biophys. Acta (1987) [Pubmed]
  20. Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability. Gordon, D.A., Jamil, H., Sharp, D., Mullaney, D., Yao, Z., Gregg, R.E., Wetterau, J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  21. The microsomal triglyceride transfer protein facilitates assembly and secretion of apolipoprotein B-containing lipoproteins and decreases cotranslational degradation of apolipoprotein B in transfected COS-7 cells. Wang, S., McLeod, R.S., Gordon, D.A., Yao, Z. J. Biol. Chem. (1996) [Pubmed]
  22. Thyroid hormone modulates the introduction of a stop codon in rat liver apolipoprotein B messenger RNA. Davidson, N.O., Powell, L.M., Wallis, S.C., Scott, J. J. Biol. Chem. (1988) [Pubmed]
  23. Apolipoprotein B binding to microsomal triglyceride transfer protein decreases with increases in length and lipidation: implications in lipoprotein biosynthesis. Hussain, M.M., Bakillah, A., Jamil, H. Biochemistry (1997) [Pubmed]
  24. Induction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1. Yang, Y., Sowden, M.P., Smith, H.C. J. Biol. Chem. (2000) [Pubmed]
  25. Normal activity of microsomal triglyceride transfer protein is required for the oleate-induced secretion of very low density lipoproteins containing apolipoprotein B from McA-RH7777 cells. Wang, Y., McLeod, R.S., Yao, Z. J. Biol. Chem. (1997) [Pubmed]
  26. In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1). Petersen-Mahrt, S.K., Neuberger, M.S. J. Biol. Chem. (2003) [Pubmed]
  27. Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats. Poirier, J., Baccichet, A., Dea, D., Gauthier, S. Neuroscience (1993) [Pubmed]
  28. Technetium-99m labelled LDL as a tracer for quantitative LDL scintigraphy. II. In vivo validation, LDL receptor-dependent and unspecific hepatic uptake and scintigraphic results. Leitha, T., Staudenherz, A., Gmeiner, B., Hermann, M., Hüttinger, M., Dudczak, R. European journal of nuclear medicine. (1993) [Pubmed]
  29. Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs. Anant, S., Mukhopadhyay, D., Hirano, K., Brasitus, T.A., Davidson, N.O. Biochim. Biophys. Acta (2002) [Pubmed]
  30. Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step. Gordon, D.A., Jamil, H., Gregg, R.E., Olofsson, S.O., Borén, J. J. Biol. Chem. (1996) [Pubmed]
  31. Estrogen replacement during hypoalbuminemia may enhance atherosclerotic risk. Joles, J.A., Bijleveld, C., van Tol, A., Geelen, M.J., Koomans, H.A. J. Am. Soc. Nephrol. (1997) [Pubmed]
  32. Altered hepatic production of apolipoproteins B and E in the fasted septic rat: factors in the development of hypertriglyceridemia. Tripp, R.J., Tabares, A., Wang, H., Lanza-Jacoby, S. J. Surg. Res. (1993) [Pubmed]
  33. Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA. Mehta, A., Kinter, M.T., Sherman, N.E., Driscoll, D.M. Mol. Cell. Biol. (2000) [Pubmed]
  34. Immunolocalization, quantitation and cellular heterogeneity of apolipoprotein B in rat hepatocytes. Corsetti, J.P., Way, B.A., Sparks, C.E., Sparks, J.D. Hepatology (1992) [Pubmed]
  35. The effect of a water-soluble tris-galactoside-terminated cholesterol derivative on the fate of low density lipoproteins and liposomes. van Berkel, T.J., Kruijt, J.K., Spanjer, H.H., Nagelkerke, J.F., Harkes, L., Kempen, H.J. J. Biol. Chem. (1985) [Pubmed]
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