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Gene Review

hydra  -  CG1338 gene product from transcript CG1338-RA

Drosophila melanogaster

Synonyms: CG1338, Dmel\CG1338
 
 
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Disease relevance of hydra

  • The hypothesis that the ratio of the adult (A) and developmental (D) toxicity of a chemical is constant across animal species has been proposed as the basis for identifying developmental hazards, both from traditional developmental toxicity screens using laboratory mammals and from alternative systems such as the coelenterate Hydra attenuata [1].
 

High impact information on hydra

  • It is shown that both Child's results about metabolic patterns and modern results for Hydra about gap junctions, 'endogeneous inhibitor' and gene expression, are correlated and explained by (cAMP, ATP) Turing theory [2].
  • In the literature, it is often assumed, for example with respect to Hydra, that several Turing systems coexist and it is also assumed that maintaining the polar profile, even when the system increases in size, is important for the polarity of the final phenotype [2].
  • Evolutionary conservation of a cell fate specification gene: the Hydra achaete-scute homolog has proneural activity in Drosophila [3].
  • There is a single achaete-scute gene in Hydra, and the bHLH domain of the predicted gene product shares a high degree of amino acid sequence similarity with those of vertebrate and Drosophila Achaete-scute proteins [3].
  • Cnox-2 is a HOM/HOX homeobox gene that we have identified in the simple metazoan Hydra vulgaris (Cnidaria: Hydrozoa) [4].
 

Biological context of hydra

  • Identification of a novel annexin in Hydra vulgaris. Characterization, cDNA cloning, and protein kinase C phosphorylation of annexin XII [5].
  • Oogenesis in Hydra: nurse cells transfer cytoplasm directly to the growing oocyte [6].
  • In a screen for receptor protein-tyrosine kinase (RTK) genes expressed during gametogenesis in the cnidarian Hydra vulgaris, we isolated a cDNA encoding Lemon, an RTK with unusual features [7].
  • Characterization of the Hydra lamin and its gene: A molecular phylogeny of metazoan lamins [8].
  • Third, the three introns of the Hydra and Priapulus genes correspond in position to the last three introns of vertebrate B-type lamin genes [8].
 

Anatomical context of hydra

 

Associations of hydra with chemical compounds

 

Other interactions of hydra

 

Analytical, diagnostic and therapeutic context of hydra

  • We used a combination of biochemical purification, Western blotting, and mass spectrometry to identify nine C. elegans chondroitin proteoglycan core proteins, none of which have homologues in vertebrates or other invertebrates such as Drosophila melanogaster or Hydra vulgaris [15].
  • As a first step toward the elucidation of a simple animal model in which to investigate annexin function, we identified, isolated, and characterized a novel annexin from Hydra vulgaris, annexin XII [5].
  • Using the polymerase chain reaction, we identified four different homeobox-containing genes in Hydra magnipapillata [16].

References

  1. Interspecies comparisons of A/D ratios: A/D ratios are not constant across species. Daston, G.P., Rogers, J.M., Versteeg, D.J., Sabourin, T.D., Baines, D., Marsh, S.S. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1991) [Pubmed]
  2. Polarity and form regulation in development and reconstitution. Schiffmann, Y. Prog. Biophys. Mol. Biol. (2001) [Pubmed]
  3. Evolutionary conservation of a cell fate specification gene: the Hydra achaete-scute homolog has proneural activity in Drosophila. Grens, A., Mason, E., Marsh, J.L., Bode, H.R. Development (1995) [Pubmed]
  4. Expression of Cnox-2, a HOM/HOX homeobox gene in hydra, is correlated with axial pattern formation. Shenk, M.A., Bode, H.R., Steele, R.E. Development (1993) [Pubmed]
  5. Identification of a novel annexin in Hydra vulgaris. Characterization, cDNA cloning, and protein kinase C phosphorylation of annexin XII. Schlaepfer, D.D., Fisher, D.A., Brandt, M.E., Bode, H.R., Jones, J.M., Haigler, H.T. J. Biol. Chem. (1992) [Pubmed]
  6. Oogenesis in Hydra: nurse cells transfer cytoplasm directly to the growing oocyte. Alexandrova, O., Schade, M., Böttger, A., David, C.N. Dev. Biol. (2005) [Pubmed]
  7. Lemon encodes an unusual receptor protein-tyrosine kinase expressed during gametogenesis in Hydra. Miller, M.A., Steele, R.E. Dev. Biol. (2000) [Pubmed]
  8. Characterization of the Hydra lamin and its gene: A molecular phylogeny of metazoan lamins. Erber, A., Riemer, D., Hofemeister, H., Bovenschulte, M., Stick, R., Panopoulou, G., Lehrach, H., Weber, K. J. Mol. Evol. (1999) [Pubmed]
  9. Intercellular communication: the Drosophila innexin multiprotein family of gap junction proteins. Bauer, R., Löer, B., Ostrowski, K., Martini, J., Weimbs, A., Lechner, H., Hoch, M. Chem. Biol. (2005) [Pubmed]
  10. Evolution of Brachyury proteins: identification of a novel regulatory domain conserved within Bilateria. Marcellini, S., Technau, U., Smith, J.C., Lemaire, P. Dev. Biol. (2003) [Pubmed]
  11. Molecular and biological characterization of a zonula occludens-1 homologue in Hydra vulgaris, named HZO-1. Fei, K., Yan, L., Zhang, J., Sarras, M.P. Dev. Genes Evol. (2000) [Pubmed]
  12. Expression pattern of the homeobox gene Not in the basal metazoan Trichoplax adhaerens. Martinelli, C., Spring, J. Gene Expr. Patterns (2004) [Pubmed]
  13. Cloning and characterisation of PKB and PRK homologs from Hydra and the evolution of the protein kinase family. Herold, M., Cikala, M., MacWilliams, H., David, C.N., Böttger, A. Dev. Genes Evol. (2002) [Pubmed]
  14. Cloning and biological function of laminin in Hydra vulgaris. Sarras, M.P., Yan, L., Grens, A., Zhang, X., Agbas, A., Huff, J.K., St John, P.L., Abrahamson, D.R. Dev. Biol. (1994) [Pubmed]
  15. Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. Olson, S.K., Bishop, J.R., Yates, J.R., Oegema, K., Esko, J.D. J. Cell Biol. (2006) [Pubmed]
  16. Presence of eight distinct homeobox-containing genes in cnidarians. Naito, M., Ishiguro, H., Fujisawa, T., Kurosawa, Y. FEBS Lett. (1993) [Pubmed]
 
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