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CALD1  -  caldesmon 1

Gallus gallus

 
 
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Disease relevance of CALD1

 

High impact information on CALD1

 

Biological context of CALD1

 

Anatomical context of CALD1

 

Associations of CALD1 with chemical compounds

  • Two isoforms of caldesmon conserve the completely identical sequences in the NH2- and COOH-terminal domains except for the insertion of Ala-508 in l-caldesmon [8].
  • Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex [10].
  • Mitosis-specific phosphorylation by cdc2 kinase causes nonmuscle caldesmon to dissociate from microfilaments (Yamashiro, S., Yamakita, Y., Ishikawa, R., and Matsumura, F. (1990) Nature 344, 675-678; Yamashiro, S., Yamakita, Y., Hosoya, H., and Matsumura, F. (1991) Nature 349, 169-172) [7].
  • To identify the tyrosine phosphorylation site(s) in the CaD molecule and to further elucidate the functional role of CaD tyrosine phosphorylation in S3-v-ErbB oncogenic signaling, we have generated a series of mutant CaDs in which one or more tyrosine residues have been replaced with phenylalanine [10].
  • Carbodiimide crosslinking with actin revealed that the 15kDa part of the molecule is probably not involved in the actin binding process but may participate in a twisting of the F-actin filament and be responsible of the caldesmon regulatory function during smooth muscle contraction [13].
 

Physical interactions of CALD1

 

Enzymatic interactions of CALD1

 

Regulatory relationships of CALD1

 

Other interactions of CALD1

 

Analytical, diagnostic and therapeutic context of CALD1

References

  1. Primary structure and functional expression of h-caldesmon complementary DNA. Hayashi, K., Kanda, K., Kimizuka, F., Kato, I., Sobue, K. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  2. Heat treatment could affect the biochemical properties of caldesmon. Zhuang, S., Mabuchi, K., Wang, C.A. J. Biol. Chem. (1996) [Pubmed]
  3. Characterization of the autophosphorylation of chicken gizzard caldesmon. Scott-Woo, G.C., Walsh, M.P. Biochem. J. (1988) [Pubmed]
  4. Immunodetection and intracellular localization of caldesmon-like proteins in Amoeba proteus. Gagola, M., Kłopocka, W., Greebecki, A., Makuch, R. Protoplasma (2003) [Pubmed]
  5. Three-dimensional reconstruction of caldesmon-containing smooth muscle thin filaments. Vibert, P., Craig, R., Lehman, W. J. Cell Biol. (1993) [Pubmed]
  6. Microinjection of nonmuscle and smooth muscle caldesmon into fibroblasts and muscle cells. Yamakita, Y., Yamashiro, S., Matsumura, F. J. Cell Biol. (1990) [Pubmed]
  7. Characterization of mitotically phosphorylated caldesmon. Yamakita, Y., Yamashiro, S., Matsumura, F. J. Biol. Chem. (1992) [Pubmed]
  8. Structural and functional relationships between h- and l-caldesmons. Hayashi, K., Fujio, Y., Kato, I., Sobue, K. J. Biol. Chem. (1991) [Pubmed]
  9. Cloning and expression of a smooth muscle caldesmon. Bryan, J., Imai, M., Lee, R., Moore, P., Cook, R.G., Lin, W.G. J. Biol. Chem. (1989) [Pubmed]
  10. Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex. Wang, Z., Danielsen, A.J., Maihle, N.J., McManus, M.J. J. Biol. Chem. (1999) [Pubmed]
  11. 35 kDa fragment of h-caldesmon conserves two consensus sequences of the tropomyosin-binding domain in troponin T. Hayashi, K., Yamada, S., Kanda, K., Kimizuka, F., Kato, I., Sobue, K. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  12. Identification of two distinct promoters in the chicken caldesmon gene. Yano, H., Hayashi, K., Haruna, M., Sobue, K. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  13. Identification of a 15 kilodalton actin binding region on gizzard caldesmon probed by chemical cross-linking. Mornet, D., Audemard, E., Derancourt, J. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  14. Both N-terminal myosin-binding and C-terminal actin-binding sites on smooth muscle caldesmon are required for caldesmon-mediated inhibition of actin filament velocity. Wang, Z., Jiang, H., Yang, Z.Q., Chacko, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  15. The role of tropomyosin in the interactions of F-actin with caldesmon and actin-binding protein (or filamin). Nomura, M., Yoshikawa, K., Tanaka, T., Sobue, K., Maruyama, K. Eur. J. Biochem. (1987) [Pubmed]
  16. Reversal of caldesmon binding to myosin with calcium-calmodulin or by phosphorylating caldesmon. Hemric, M.E., Lu, F.W., Shrager, R., Carey, J., Chalovich, J.M. J. Biol. Chem. (1993) [Pubmed]
  17. Evidence against the regulation of caldesmon inhibitory activity by p42/p44erk mitogen-activated protein kinase in vitro and demonstration of another caldesmon kinase in intact gizzard smooth muscle. Krymsky, M.A., Chibalina, M.V., Shirinsky, V.P., Marston, S.B., Vorotnikov, A.V. FEBS Lett. (1999) [Pubmed]
  18. Caldesmon and a 20-kDa actin-binding fragment of caldesmon inhibit tension development in skinned gizzard muscle fiber bundles. Pfitzer, G., Zeugner, C., Troschka, M., Chalovich, J.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Calcium-dependent regulation of interactions of caldesmon with calcium-binding proteins found in growth cones of chick forebrain neurons. Alexanian, A.R., Bamburg, J.R., Hidaka, H., Mornet, D. Cell. Mol. Neurobiol. (2001) [Pubmed]
  20. Smooth muscle caldesmon. Rapid purification and F-actin cross-linking properties. Bretscher, A. J. Biol. Chem. (1984) [Pubmed]
  21. Caldesmon-binding sites on tropomyosin. Watson, M.H., Kuhn, A.E., Novy, R.E., Lin, J.J., Mak, A.S. J. Biol. Chem. (1990) [Pubmed]
  22. Reconstitution of Ca2+-sensitive gelation of actin filaments with filamin, caldesmon and calmodulin. Sobue, K., Morimoto, K., Kanda, K., Maruyama, K., Kakiuchi, S. FEBS Lett. (1982) [Pubmed]
 
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