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Gene Review

mus201  -  mutagen-sensitive 201

Drosophila melanogaster

Synonyms: 55A11T, CG10890, CG32956, DmXPG, Dmel\CG10890, ...
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Disease relevance of mus201


High impact information on mus201

  • That protein restores both excision repair and UV resistance to mei-9 and mus201 mutants of this organism [1].
  • With oocytes deficient for XPG (DmXPG), frequencies were enhanced up to 50 times [3].
  • MEC induced 64% deletions and other DNA rearrangements in crosses of males with DmXPG females [3].
  • Inactivation of NER had no potentiating effect on clastogenic events (chromosome loss) induced by CEA, which is in sharp contrast to the strongly enhanced forward mutation frequencies measured with DmXPG females [3].
  • When exr+ males, after exposure to DBE, were mated to excision repair deficient (exr-) mus 201 females 11 of 14 mutational events isolated from either F1 or F2 progeny were single bp changes [4].

Biological context of mus201

  • XPG(Dm) is encoded by the mus201 gene; we found frameshift mutations predicted to produce truncated XPG(Dm) proteins in each of two mus201 alleles [5].
  • The absence of a potentiating effect of mus201 on EO-induced clastogenicity suggests the formation of clastogenic DNA lesions not causing point mutations, and which are not repaired by NER [6].
  • The pattern of EO-induced ring chromosome loss (CL) differed in two respects from that observed for forward mutations: (a) an increase in CL frequencies was observed only at the two highest EO exposure levels, and (b) inactivation of the NER pathway by the mus201 mutant had no measurable effect on the occurrence of CL [6].
  • In this article, we study the consequences, with the w(i) assay, of the introduction of two mutations, mus201 and mei-41, which produce deficiency in two different repair mechanisms: the nucleotide excision repair system and in a G2/M cell-cycle checkpoint, respectively [7].
  • Comparison of excision repair-deficient mei-9a and mus201 females in the test for paternal sex chromosome loss in drosophila with procarbazine and diethylnitrosamine (DEN) [8].

Anatomical context of mus201

  • The causes of the discrepancy between the extraordinarily high activity of MEC in mus201 somatic cells and its low potentiating effect in germ cells is unknown at present [9].
  • These established cell lines can therefore be used as appropriate models for both the examination of the biochemical basis of the genetic defects in the mei-9 and mus201 mutations and the role of excision-repair processes in spontaneous and induced mutation induction in eukaryotic cells [10].

Associations of mus201 with chemical compounds


Other interactions of mus201

  • We report here the identification of the genes encoding the XPG and ERCC1 homologues (XPG(Dm) and ERCC1(Dm)) [5].
  • Cells derived from two nonallelic excision-defective mutants (mei-9 and mus201) exhibit the same quantitative decline in both phenomena as do control cells [15].
  • The hypermutability indices obtained were 2.59 for mus201 and 0.52 for mus308 conditions [16].

Analytical, diagnostic and therapeutic context of mus201


  1. denV gene of bacteriophage T4 restores DNA excision repair to mei-9 and mus201 mutants of Drosophila melanogaster. Banga, S.S., Boyd, J.B., Valerie, K., Harris, P.V., Kurz, E.M., de Riel, J.K. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  2. Drosophila mutations at the mei-9 and mus(2)201 loci which block excision of thymine dimers also block induction of unscheduled DNA synthesis by methyl methanesulfonate, ethyl methanesulfonate, N-methyl-N-nitrosourea, UV light and X-rays. Dusenbery, R.L., McCormick, S.C., Smith, P.D. Mutat. Res. (1983) [Pubmed]
  3. The in vivo genetic activity profile of the monofunctional nitrogen mustard 2-chloroethylamine differs drastically from its bifunctional counterpart mechlorethamine. Wijen, J.P., Nivard, M.J., Vogel, E.W. Carcinogenesis (2000) [Pubmed]
  4. Mutation spectra of 1,2-dibromoethane, 1,2-dichloroethane and 1-bromo-2-chloroethane in excision repair proficient and repair deficient strains of Drosophila melanogaster. Ballering, L.A., Nivard, M.J., Vogel, E.W. Carcinogenesis (1994) [Pubmed]
  5. Nucleotide excision repair endonuclease genes in Drosophila melanogaster. Sekelsky, J.J., Hollis, K.J., Eimerl, A.I., Burtis, K.C., Hawley, R.S. Mutat. Res. (2000) [Pubmed]
  6. Genotoxic effects of inhaled ethylene oxide, propylene oxide and butylene oxide on germ cells: sensitivity of genetic endpoints in relation to dose and repair status. Vogel, E.W., Nivard, M.J. Mutat. Res. (1998) [Pubmed]
  7. White-ivory assay of Drosophila melanogaster under deficient repair conditions. Ferreiro, J.A., Sierra, L.M., Comendador, M.A. Environ. Mol. Mutagen. (1998) [Pubmed]
  8. Comparison of excision repair-deficient mei-9a and mus201 females in the test for paternal sex chromosome loss in drosophila with procarbazine and diethylnitrosamine (DEN). Zimmering, S., Kammermeyer, K.L. Environmental mutagenesis. (1983) [Pubmed]
  9. Phenotypes of Drosophila homologs of human XPF and XPG to chemically-induced DNA modifications. Vogel, E.W., Nivard, M.J. Mutat. Res. (2001) [Pubmed]
  10. Equivalence of UDS responses for established cell lines and primary cells derived from the mei-9a and mus201D1 excision repair-deficient strains of Drosophila melanogaster. Dusenbery, R.L., Lee-Chen, S.F. Mutat. Res. (1988) [Pubmed]
  11. Re-evaluation of excision repair in the mus304, mus306 and mus308 mutants of Drosophila. Harris, P.V., Boyd, J.B. Mutat. Res. (1993) [Pubmed]
  12. In vivo repair of ENU-induced oxygen alkylation damage by the nucleotide excision repair mechanism in Drosophila melanogaster. Tosal, L., Comendador, M.A., Sierra, L.M. Mol. Genet. Genomics (2001) [Pubmed]
  13. Impact of DNA nucleotide excision repair on methyl methanesulfonate-induced mutations in Drosophila melanogaster. Nivard, M.J., Pastink, A., Vogel, E.W. Carcinogenesis (1993) [Pubmed]
  14. Mutagenic activity of ethylene oxide and propylene oxide under XPG proficient and deficient conditions in relation to N-7-(2-hydroxyalkyl)guanine levels in Drosophila. Nivard, M.J., Czene, K., Segerbäck, D., Vogel, E.W. Mutat. Res. (2003) [Pubmed]
  15. Postreplication repair-defective mutants of Drosophila melanogaster fall into two classes. Brown, T.C., Boyd, J.B. Mol. Gen. Genet. (1981) [Pubmed]
  16. Acrolein genotoxicity in Drosophila melanogaster. II. Influence of mus201 and mus308 mutations. Barros, A.R., Comendador, M.A., Sierra, L.M. Mutat. Res. (1994) [Pubmed]
  17. Influence of mus201 and mus308 mutations of Drosophila melanogaster on the genotoxicity of model chemicals in somatic cells in vivo measured with the comet assay. Bilbao, C., Ferreiro, J.A., Comendador, M.A., Sierra, L.M. Mutat. Res. (2002) [Pubmed]
  18. Analysis of genomic damage in the mutagen-sensitive mus-201 mutant of Drosophila melanogaster by arbitrarily primed PCR (AP-PCR) fingerprinting. López, A., Xamena, N., Cabré, O., Creus, A., Marcos, R., Velázquez, A. Mutat. Res. (1999) [Pubmed]
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