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Gene Review

IL31  -  interleukin 31

Homo sapiens

Synonyms: IL-31, Interleukin-31
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Disease relevance of IL31


High impact information on IL31


Chemical compound and disease context of IL31


Biological context of IL31


Anatomical context of IL31

  • IL-31 protein production by skin-homing cutaneous lymphocyte antigen (CLA)-positive T cells was also assessed [1].
  • Analysis of the soluble receptor distribution revealed a preferential expression in lung, liver, pancreas, and placenta. sOSMR was able to bind OSM and interleukin-31 when associated to soluble gp130 or soluble interleukin-31R, respectively, and to neutralize both cytokine properties [7].
  • In vitro, staphylococcal enterotoxin B but not viruses or T(H)1 and T(H)2 cytokines induced IL-31 in leukocytes [2].
  • IL-31 receptor A showed most abundant expression in dorsal root ganglia representing the site where the cell bodies of cutaneous sensory neurons reside [2].
  • For example, the discovery of IL-27 has greatly improved our understanding of the factors regulating the polarization of the T helper cell responses and IL-31 appears to be an important regulator of Th2 responses [8].

Other interactions of IL31

  • SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31 [6].

Analytical, diagnostic and therapeutic context of IL31


  1. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. Bilsborough, J., Leung, D.Y., Maurer, M., Howell, M., Boguniewcz, M., Yao, L., Storey, H., LeCiel, C., Harder, B., Gross, J.A. J. Allergy Clin. Immunol. (2006) [Pubmed]
  2. IL-31: a new link between T cells and pruritus in atopic skin inflammation. Sonkoly, E., Muller, A., Lauerma, A.I., Pivarcsi, A., Soto, H., Kemeny, L., Alenius, H., Dieu-Nosjean, M.C., Meller, S., Rieker, J., Steinhoff, M., Hoffmann, T.K., Ruzicka, T., Zlotnik, A., Homey, B. J. Allergy Clin. Immunol. (2006) [Pubmed]
  3. IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. Perrigoue, J.G., Li, J., Zaph, C., Goldschmidt, M., Scott, P., de Sauvage, F.J., Pearce, E.J., Ghilardi, N., Artis, D. J. Exp. Med. (2007) [Pubmed]
  4. Interleukin-31 and oncostatin-m mediate distinct signaling reactions and response patterns in lung epithelial cells. Chattopadhyay, S., Tracy, E., Liang, P., Robledo, O., Rose-John, S., Baumann, H. J. Biol. Chem. (2007) [Pubmed]
  5. Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31. Broxmeyer, H.E., Li, J., Hangoc, G., Cooper, S., Tao, W., Mantel, C., Graham-Evans, B., Ghilardi, N., de Sauvage, F.J. Exp. Hematol. (2007) [Pubmed]
  6. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. Diveu, C., Lak-Hal, A.H., Froger, J., Ravon, E., Grimaud, L., Barbier, F., Hermann, J., Gascan, H., Chevalier, S. Eur. Cytokine Netw. (2004) [Pubmed]
  7. Molecular and functional characterization of a soluble form of oncostatin m/interleukin-31 shared receptor. Diveu, C., Venereau, E., Froger, J., Ravon, E., Grimaud, L., Rousseau, F., Chevalier, S., Gascan, H. J. Biol. Chem. (2006) [Pubmed]
  8. The newest interleukins: recent additions to the ever-growing cytokine family. Chen, Q., Carroll, H.P., Gadina, M. Vitam. Horm. (2006) [Pubmed]
  9. Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis. Takaoka, A., Arai, I., Sugimoto, M., Yamaguchi, A., Tanaka, M., Nakaike, S. Eur. J. Pharmacol. (2005) [Pubmed]
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