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Gene Review

KRTAP26-1  -  keratin associated protein 26-1

Homo sapiens

Synonyms: KAP26.1, Keratin-associated protein 26-1
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Disease relevance of KRTAP26-1


High impact information on KRTAP26-1

  • To study the mechanism of keratin-associated predisposition to liver injury, we used mouse microarrays to examine genetic changes associated with hepatocyte keratin mutation and assessed the consequences of such changes [4].
  • This work characterizes eight recently identified high glycine/tyrosine (HGT)-type KAP genes collectively designated Krtap16-n. These genes are shown to be integrated into a larger KAP gene domain on mouse chromosome 16 (MMU16) that is orthologous to a recently described HGT- and high sulfur (HS)-type KAP gene complex on human chromosome 21q22.11 [5].
  • 1. This domain, present on the DNA accession numbers and, was approximately 535 kb in size and contained 17 high glycine-tyrosine and 7 high sulfur KAP genes, as well as 9 KAP pseudogenes [6].
  • Based on amino acid sequence comparisons of the encoded proteins, the KAP genes could be divided into seven high glycine-tyrosine gene families (KAP6-KAP8, and KAP19-KAP22) and four high sulfur gene families (KAP11, KAP13, KAP15, and KAP23) [6].
  • The high glycine-tyrosine genes described here appear to represent the complete set of this type of KAP genes present in the human genome [6].

Biological context of KRTAP26-1


Anatomical context of KRTAP26-1


Associations of KRTAP26-1 with chemical compounds

  • Glycosidase digestion showed that KAP85 contains high mannose and complex oligosaccharides [14].
  • Our results demonstrate in vitro evidence of a membrane-associated glycoprotein (KAP85) which may serve as an attachment site for filamentous K8/18 [14].
  • Of these areas, only a proportion (70%) showed increased NBT staining, confirming the lack of correspondence between keratin-associated pimonidazole staining and reductase levels [15].
  • These KAPs also showed high glycine and serine contents (average 24.30 and 21.13 mol%, respectively), distinguishing from other UHS/HS KAP families located on human chromosomes 17 and 21 [9].
  • Based on the deduced amino acid sequences, all these KAP proteins were classified into an ultrahigh-sulfur (UHS) type KAP with high cysteine content (> 30 mol%) [9].

Co-localisations of KRTAP26-1

  • Subcellular fractionation showed that KAP85 co-localizes with a plasma-membrane-enriched fraction that includes the transferrin receptor and KS-1 antigen [14].

Other interactions of KRTAP26-1


Analytical, diagnostic and therapeutic context of KRTAP26-1


  1. Clouston syndrome (hidrotic ectodermal dysplasia) is not linked to keratin gene clusters on chromosomes 12 and 17. Hayflick, S.J., Taylor, T., McKinnon, W., Guttmacher, A.E., Litt, M., Zonana, J. J. Invest. Dermatol. (1996) [Pubmed]
  2. Human keratin diseases: hereditary fragility of specific epithelial tissues. Corden, L.D., McLean, W.H. Exp. Dermatol. (1996) [Pubmed]
  3. Analysis of the transcriptional regulation of melanocytic genes by alphaMSH using the cDNA microarray technique. Rouzaud, F., Hearing, V.J. Cell. Mol. Biol. (Noisy-le-grand) (2006) [Pubmed]
  4. Keratin mutation primes mouse liver to oxidative injury. Zhou, Q., Ji, X., Chen, L., Greenberg, H.B., Lu, S.C., Omary, M.B. Hepatology (2005) [Pubmed]
  5. Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13. Pruett, N.D., Tkatchenko, T.V., Jave-Suarez, L., Jacobs, D.F., Potter, C.S., Tkatchenko, A.V., Schweizer, J., Awgulewitsch, A. J. Biol. Chem. (2004) [Pubmed]
  6. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. Rogers, M.A., Langbein, L., Winter, H., Ehmann, C., Praetzel, S., Schweizer, J. J. Biol. Chem. (2002) [Pubmed]
  7. Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21. Rogers, M.A., Langbein, L., Winter, H., Beckmann, I., Praetzel, S., Schweizer, J. J. Invest. Dermatol. (2004) [Pubmed]
  8. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. Shibuya, K., Obayashi, I., Asakawa, S., Minoshima, S., Kudoh, J., Shimizu, N. Genomics (2004) [Pubmed]
  9. Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. Yahagi, S., Shibuya, K., Obayashi, I., Masaki, H., Kurata, Y., Kudoh, J., Shimizu, N. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  10. Comparative genomics of the keratin-associated protein (KAP) gene clusters in human, chimpanzee, and baboon. Shibuya, K., Kudoh, J., Obayashi, I., Shimizu, A., Sasaki, T., Minoshima, S., Shimizu, N. Mamm. Genome (2004) [Pubmed]
  11. hKAP1.6 and hKAP1.7, two novel human high sulfur keratin-associated proteins are expressed in the hair follicle cortex. Shimomura, Y., Aoki, N., Rogers, M.A., Langbein, L., Schweizer, J., Ito, M. J. Invest. Dermatol. (2002) [Pubmed]
  12. A monoclonal antibody recognizing a keratin filament protein in a subset of transitional and glandular epithelia. Nadakavukaren, K.K., Summerhayes, I.C., Salcedo, B.F., Rheinwald, J.G., Chen, L.B. Differentiation (1984) [Pubmed]
  13. Foreward:alpha-melanocyte stimulating hormone and the melanocortin receptors. Taylor, A. Cell. Mol. Biol. (Noisy-le-grand) (2006) [Pubmed]
  14. Identification of a keratin-associated protein that localizes to a membrane compartment. Chou, C.F., Riopel, C.L., Omary, M.B. Biochem. J. (1994) [Pubmed]
  15. Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors. Janssen, H.L., Hoebers, F.J., Sprong, D., Goethals, L., Williams, K.J., Stratford, I.J., Haustermans, K.M., Balm, A.J., Begg, A.C. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2004) [Pubmed]
  16. Association of glucose-regulated protein (grp78) with human keratin 8. Liao, J., Price, D., Omary, M.B. FEBS Lett. (1997) [Pubmed]
  17. A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus. Terrinoni, A., Puddu, P., Didona, B., De Laurenzi, V., Candi, E., Smith, F.J., McLean, W.H., Melino, G. J. Invest. Dermatol. (2000) [Pubmed]
  18. Regulation of human profilaggrin promoter activity in cultured epithelial cells by retinoic acid and glucocorticoids. Presland, R.B., Tomic-Canic, M., Lewis, S.P., Dale, B.A. J. Dermatol. Sci. (2001) [Pubmed]
  19. Isolation and characterization of genomic clones of human sequences presumably coding for hair cysteine-rich proteins. Emonet, N., Michaille, J.J., Dhouailly, D. J. Dermatol. Sci. (1997) [Pubmed]
  20. Scale keratin in lizard epidermis reveals amino acid regions homologous with avian and mammalian epidermal proteins. Alibardi, L., Dalla Valle, L., Toffolo, V., Toni, M. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2006) [Pubmed]
  21. Characterization of human keratin-associated protein 1 family members. Shimomura, Y., Aoki, N., Rogers, M.A., Langbein, L., Schweizer, J., Ito, M. J. Investig. Dermatol. Symp. Proc. (2003) [Pubmed]
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