The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PTK2  -  protein tyrosine kinase 2

Gallus gallus

Synonyms: FAK, FRNK, p125FAK
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PTK2

  • The replication deficient adenovirus containing the FAK gene (pp125 FAK) was constructed and named Adv-Fak [1].
  • To determine whether increased FAK and paxillin protein concentrations are associated with hypertrophy and/or new fiber formation, two additional experiments were performed [2].
  • Second, FAK (112% and 611%) and paxillin (87% and 431%) protein concentrations per unit of total protein in the soleus muscle increased at 1 and 8 days after surgical ablation of the synergistic gastrocnemius muscle (a model of hypertrophy without hyperplasia) [2].

High impact information on PTK2

  • We propose that pp41/43FRNK functions as an endogenous regulator of pp125FAK, thus providing an unusual means to regulate both tyrosine kinase activity and cellular adhesion to the extracellular matrix [3].
  • Src binds to focal adhesion kinase (FAK) through its SH2 domain and subsequently activates it for phosphorylation of downstream substrates [4].
  • These data show that Src-mediated phosphorylation of FAK acts as a pivotal regulator of both actin and adhesion dynamics and survival signaling, which, in turn, control apparently distinct processes such as cell migration and anchorage-independent growth [5].
  • Expression of 4-9F-FAK in FAK-deficient fibroblasts also disrupts F-actin assembly associated with normal adhesion and spreading [5].
  • When ectopically expressed in cells, FRNK has been shown to act as a negative regulator of FAK activity, inhibiting cell spreading, migration, and cell cycle progression [6].

Biological context of PTK2


Anatomical context of PTK2


Associations of PTK2 with chemical compounds


Enzymatic interactions of PTK2


Other interactions of PTK2


Analytical, diagnostic and therapeutic context of PTK2

  • FAK (77 and 81%) and paxillin (206 and 202%) protein concentrations per unit of total protein in Western blots increased significantly after 1.5 and 7 days, but not after 13 days, of stretch-induced hypertrophy-hyperplasia of the ALD muscle [2].


  1. In vivo gene transfer and overexpression of focal adhesion kinase (pp125 FAK) mediated by recombinant adenovirus-induced tendon adhesion formation and epitenon cell change. Lou, J., Kubota, H., Hotokezaka, S., Ludwig, F.J., Manske, P.R. J. Orthop. Res. (1997) [Pubmed]
  2. Focal adhesion proteins FAK and paxillin increase in hypertrophied skeletal muscle. Flück, M., Carson, J.A., Gordon, S.E., Ziemiecki, A., Booth, F.W. Am. J. Physiol. (1999) [Pubmed]
  3. A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Richardson, A., Parsons, T. Nature (1996) [Pubmed]
  4. Src SH2 arginine 175 is required for cell motility: specific focal adhesion kinase targeting and focal adhesion assembly function. Yeo, M.G., Partridge, M.A., Ezratty, E.J., Shen, Q., Gundersen, G.G., Marcantonio, E.E. Mol. Cell. Biol. (2006) [Pubmed]
  5. SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling. Westhoff, M.A., Serrels, B., Fincham, V.J., Frame, M.C., Carragher, N.O. Mol. Cell. Biol. (2004) [Pubmed]
  6. Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase. Nolan, K., Lacoste, J., Parsons, J.T. Mol. Cell. Biol. (1999) [Pubmed]
  7. Chicken and mouse focal adhesion kinases are similar in structure at their amino termini. Devor, B.B., Zhang, X., Patel, S.K., Polte, T.R., Hanks, S.K. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  8. Crystal structure of the FERM domain of focal adhesion kinase. Ceccarelli, D.F., Song, H.K., Poy, F., Schaller, M.D., Eck, M.J. J. Biol. Chem. (2006) [Pubmed]
  9. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. Gervais, F.G., Thornberry, N.A., Ruffolo, S.C., Nicholson, D.W., Roy, S. J. Biol. Chem. (1998) [Pubmed]
  10. Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Peng, X., Ueda, H., Zhou, H., Stokol, T., Shen, T.L., Alcaraz, A., Nagy, T., Vassalli, J.D., Guan, J.L. Cardiovasc. Res. (2004) [Pubmed]
  11. Signal transduction of mechanical stimuli is dependent on microfilament integrity: identification of osteopontin as a mechanically induced gene in osteoblasts. Toma, C.D., Ashkar, S., Gray, M.L., Schaffer, J.L., Gerstenfeld, L.C. J. Bone Miner. Res. (1997) [Pubmed]
  12. The fibroblast growth factor receptor FGFR-4 acts as a ligand dependent modulator of erythroid cell proliferation. Koritschoner, N.P., Bartůnĕk, P., Knespel, S., Blendinger, G., Zenke, M. Oncogene (1999) [Pubmed]
  13. mu-Opioids activate tyrosine kinase focal adhesion kinase and regulate cortical cytoskeleton proteins cortactin and vinculin in chick embryonic neurons. Mangoura, D. J. Neurosci. Res. (1997) [Pubmed]
  14. Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. Schaller, M.D., Borgman, C.A., Parsons, J.T. Mol. Cell. Biol. (1993) [Pubmed]
  15. Glutamate activates PP125(FAK) through AMPA/kainate receptors in Bergmann glia. Millán, A., Aguilar, P., Méndez, J.A., Arias-Montaño, J.A., Ortega, A. J. Neurosci. Res. (2001) [Pubmed]
  16. Vanadate-dependent FAK activation is accomplished by the sustained FAK Tyr-576/577 phosphorylation. Maa, M.C., Leu, T.H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  17. v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts. Fincham, V.J., Wyke, J.A., Frame, M.C. Oncogene (1995) [Pubmed]
WikiGenes - Universities