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Chemical Compound Review

Diathesin     2-(hydroxymethyl)phenol

Synonyms: Saligenin, Saligenol, Salicylalkohol, PubChem15359, PubChem21869, ...
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Disease relevance of Salicylalkohol


Psychiatry related information on Salicylalkohol


High impact information on Salicylalkohol


Biological context of Salicylalkohol


Anatomical context of Salicylalkohol

  • Previous studies have shown that after dosing with tri-o-cresyl phosphate (TOCP), the testis contains more active intermediate (saligenin cyclic-o-tolyl phosphate; SCOTP) than do other organs or blood [12].
  • To assess the relationship of nerve conduction and adenosine triphosphate (ATP) status in organophosphorus-induced delayed neuropathy (OPIDN), we evaluated both in adult hen peripheral nerves following exposure to a single 2.5 mg/kg dose of phenyl saligenin phosphate (PSP) [11].
  • Trace amounts of saligenin cyclic-o-tolyl phosphate, hydroxymethyl, and di(hydroxymethyl) TOCP were also detected in the urine and feces [13].
  • The response of peripheral blood vessels to adrenergic and cholinergic agonists was examined 1, 3, 7, and 21 d after hens were treated with a single intramuscular injection of 2.5 mg/kg cyclic phenyl saligenin phosphate (PSP) or 0.10 mg/kg paraoxon (PXN) [14].

Associations of Salicylalkohol with other chemical compounds


Gene context of Salicylalkohol

  • Testes in rats given ten doses had significantly more TOCP and saligenin cyclic-o-tolyl phosphate than those from rats given a single dose [16].


  1. Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity. Hargreaves, A.J., Fowler, M.J., Sachana, M., Flaskos, J., Bountouri, M., Coutts, I.C., Glynn, P., Harris, W., Graham McLean, W. Biochem. Pharmacol. (2006) [Pubmed]
  2. Allergic contact dermatitis from salicyl alcohol and salicylaldehyde in aspen bark (Populus tremula). Aalto-Korte, K., Välimaa, J., Henriks-Eckerman, M.L., Jolanki, R. Contact Derm. (2005) [Pubmed]
  3. Enzymatic synthesis of two salicin analogues by reaction of salicyl alcohol with Bacillus macerans cyclomaltodextrin glucanyltransferase and Leuconostoc mesenteroides B-742CB dextransucrase. Yoon, S.H., Bruce Fulton, D., Robyt, J.F. Carbohydr. Res. (2004) [Pubmed]
  4. Organophosphorus pesticide-induced butyrylcholinesterase inhibition and potentiation of succinylcholine toxicity in mice. Sparks, S.E., Quistad, G.B., Casida, J.E. J. Biochem. Mol. Toxicol. (1999) [Pubmed]
  5. Effects of organophosphorus compounds on ATP production and mitochondrial integrity in cultured cells. Massicotte, C., Knight, K., Van der Schyf, C.J., Jortner, B.S., Ehrich, M. Neurotoxicity research. (2005) [Pubmed]
  6. Salmeterol xinafoate. A review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease. Brogden, R.N., Faulds, D. Drugs (1991) [Pubmed]
  7. Potentiation by salicylate and salicyl alcohol of cadmium toxicity and accumulation in Escherichia coli. Rosner, J.L., Aumercier, M. Antimicrob. Agents Chemother. (1990) [Pubmed]
  8. Synthesis of the beta 2 agonist (R)-salmeterol using a sequence of supported reagents and scavenging agents. Bream, R.N., Ley, S.V., Procopiou, P.A. Org. Lett. (2002) [Pubmed]
  9. Salicylate induction of antibiotic resistance in Escherichia coli: activation of the mar operon and a mar-independent pathway. Cohen, S.P., Levy, S.B., Foulds, J., Rosner, J.L. J. Bacteriol. (1993) [Pubmed]
  10. Monitoring carbohydrate enzymatic reactions by quantitative in vitro microdialysis. Modi, S.J., LaCourse, W.R. Journal of chromatography. A. (2006) [Pubmed]
  11. Nerve conduction and ATP concentrations in sciatic-tibial and medial plantar nerves of hens given phenyl saligenin phosphate. Massicotte, C., Barber, D.S., Jortner, B.S., Ehrich, M. Neurotoxicology (2001) [Pubmed]
  12. The interaction of Sertoli and Leydig cells in the testicular toxicity of tri-o-cresyl phosphate. Chapin, R.E., Phelps, J.L., Somkuti, S.G., Heindel, J.J., Burka, L.T. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
  13. Studies on the metabolism of the neurotoxic tri-o-cresyl phosphate. Distribution, excretion, and metabolism in male cats after a single, dermal application. Nomeir, A.A., Abou-Donia, M.B. Toxicology (1986) [Pubmed]
  14. Effect of cyclic phenyl saligenin phosphate and paraoxon treatment on vascular response to adrenergic and cholinergic agents in hens. McCain, W.C., Wilcke, J., Lee, J.C., Ehrich, M. Journal of toxicology and environmental health. (1995) [Pubmed]
  15. The influence of chirality on the delayed neuropathic potential of some organophosphorus esters: neuropathic and prophylactic effects of stereoisomeric esters of ethyl phenylphosphonic acid (EPN oxon and EPN) correlate with quantities of aged and unaged neuropathy target esterase in vivo. Johnson, M.K., Read, D.J. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  16. Disposition, elimination, and metabolism of tri-o-cresyl phosphate following daily oral administration in Fischer 344 male rats. Somkuti, S.G., Abou-Donia, M.B. Arch. Toxicol. (1990) [Pubmed]
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