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Gene Review

FGF2  -  fibroblast growth factor 2 (basic)

Sus scrofa

 
 
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Disease relevance of FGF2

 

High impact information on FGF2

 

Chemical compound and disease context of FGF2

  • CONCLUSIONS: Selective pressure-regulated retroinfusion increased tissue binding of FGF-2 and enhanced functionally relevant collateral perfusion compared with antegrade intracoronary delivery in pigs with chronic myocardial ischemia [2].
 

Biological context of FGF2

 

Anatomical context of FGF2

  • The regulation of the basic fibroblast growth factor (bFGF, or FGF-2) receptor on porcine granulosa cells was studied [10].
  • In the presence of FGF2 (20 ng/mL), the percentage of photoreceptor survival during the second week in culture was statistically significantly different, at least two times higher than in control experiments [14].
  • Levels of natriuretic peptides were significantly decreased, and levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF2) were significantly increased after BMI [15].
  • CONCLUSIONS: The function of ischemic myocardium can be restored by a novel FGF2 gene delivery method using a gene-activated matrix [1].
  • In a separate series of experiments porcine coronary arteries were chronically treated with FGF-2 itself in the same manner [16].
 

Associations of FGF2 with chemical compounds

  • EB induced a significant suppression of FGF-2 mRNA, an effect which was antagonized by P and even prevented by P+EB [9].
  • Phosphotyrosine immunoblots after stimulation of cultures with FGF2 and EGF revealed time-dependent appearance of multiple immunoreactive bands [14].
  • Under these conditions, both inducers stimulated rapid activation of extracellular signal-regulated kinase (ERK2) at 5-10 min, a transient and lower intensity being induced by U46619 whereas that induced by FGF-2 was sustained (>1 h) [17].
  • However, activation of ERK2 by FGF-2 was not affected by PGE2 whereas that of JNK1 by U46619 was inhibited, suggesting that inhibition of COX-2 expression by cAMP may be downstream of ERK2 [17].
  • Short heparin sequences spaced by glycol-split uronate residues are antagonists of fibroblast growth factor 2 and angiogenesis inhibitors [18].
 

Regulatory relationships of FGF2

  • In contrast, activation of Jun-N-terminal kinase (JNK1) was sustained with U46619 but poorly induced by FGF-2 [17].
 

Other interactions of FGF2

 

Analytical, diagnostic and therapeutic context of FGF2

References

  1. Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging. Horvath, K.A., Doukas, J., Lu, C.Y., Belkind, N., Greene, R., Pierce, G.F., Fullerton, D.A. Ann. Thorac. Surg. (2002) [Pubmed]
  2. Selective pressure-regulated retroinfusion of fibroblast growth factor-2 into the coronary vein enhances regional myocardial blood flow and function in pigs with chronic myocardial ischemia. von Degenfeld, G., Raake, P., Kupatt, C., Lebherz, C., Hinkel, R., Gildehaus, F.J., Münzing, W., Kranz, A., Waltenberger, J., Simoes, M., Schwaiger, M., Thein, E., Boekstegers, P. J. Am. Coll. Cardiol. (2003) [Pubmed]
  3. Effect of basic fibroblast growth factor on angiogenesis in the infarcted porcine heart. Watanabe, E., Smith, D.M., Sun, J., Smart, F.W., Delcarpio, J.B., Roberts, T.B., Van Meter, C.H., Claycomb, W.C. Basic Res. Cardiol. (1998) [Pubmed]
  4. Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo. Nabel, E.G., Yang, Z.Y., Plautz, G., Forough, R., Zhan, X., Haudenschild, C.C., Maciag, T., Nabel, G.J. Nature (1993) [Pubmed]
  5. Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia. Nugent, M.A., Nugent, H.M., Iozzo, R.V., Sanchack, K., Edelman, E.R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. GDNF family ligands trigger indirect neuroprotective signaling in retinal glial cells. Hauck, S.M., Kinkl, N., Deeg, C.A., Swiatek-de Lange, M., Schöffmann, S., Ueffing, M. Mol. Cell. Biol. (2006) [Pubmed]
  7. Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate. Implications for dynamic assembly of a ternary signaling complex. Powell, A.K., Fernig, D.G., Turnbull, J.E. J. Biol. Chem. (2002) [Pubmed]
  8. Requirement for anticoagulant heparan sulfate in the fibroblast growth factor receptor complex. McKeehan, W.L., Wu, X., Kan, M. J. Biol. Chem. (1999) [Pubmed]
  9. Developmental and hormonal regulated gene expression of fibroblast growth factor 2 (FGF-2) and its receptors in porcine endometrium. Welter, H., Wollenhaupt, K., Einspanier, R. J. Steroid Biochem. Mol. Biol. (2004) [Pubmed]
  10. Protein kinase C-dependent down-regulation of basic fibroblast growth factor (FGF-2) receptor by phorbol ester and epidermal growth factor in porcine granulosa cells. Asakai, R., Akita, Y., Tamura, K., Kenmotsu, N., Aoyama, Y. Endocrinology (1995) [Pubmed]
  11. MEK hyperphosphorylation coincides with cell cycle shut down of cultured smooth muscle cells. Vogel, S., Kubin, T., von der Ahe, D., Deindl, E., Schaper, W., Zimmermann, R. J. Cell. Physiol. (2006) [Pubmed]
  12. Transendocardial and transepicardial intramyocardial fibroblast growth factor-2 administration: myocardial and tissue distribution. Laham, R.J., Post, M., Rezaee, M., Donnell-Fink, L., Wykrzykowska, J.J., Lee, S.U., Baim, D.S., Sellke, F.W. Drug Metab. Dispos. (2005) [Pubmed]
  13. Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia. Sato, K., Laham, R.J., Pearlman, J.D., Novicki, D., Sellke, F.W., Simons, M., Post, M.J. Ann. Thorac. Surg. (2000) [Pubmed]
  14. Basic fibroblast and epidermal growth factors stimulate survival in adult porcine photoreceptor cell cultures. Traverso, V., Kinkl, N., Grimm, L., Sahel, J., Hicks, D. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  15. A strategy of retrograde injection of bone marrow mononuclear cells into the myocardium for the treatment of ischemic heart disease. Yokoyama, S., Fukuda, N., Li, Y., Hagikura, K., Takayama, T., Kunimoto, S., Honye, J., Saito, S., Wada, M., Satomi, A., Kato, M., Mugishima, H., Kusumi, Y., Mitsumata, M., Murohara, T. J. Mol. Cell. Cardiol. (2006) [Pubmed]
  16. The role of fibroblast growth factor-2 in the vascular effects of interleukin-1 beta in porcine coronary arteries in vivo. Ito, A., Shimokawa, H., Fukumoto, Y., Kadokami, T., Nakaike, R., Takayanagi, T., Egashira, K., Sueishi, K., Takeshita, A. Cardiovasc. Res. (1996) [Pubmed]
  17. Regulatory role of prostaglandin E2 in induction of cyclo-oxygenase-2 by a thromboxane A2 analogue (U46619) and basic fibroblast growth factor in porcine aortic smooth-muscle cells. Karim, S., Berrou, E., Lévy-Toledano, S., Bryckaert, M., MacLouf, J. Biochem. J. (1997) [Pubmed]
  18. Short heparin sequences spaced by glycol-split uronate residues are antagonists of fibroblast growth factor 2 and angiogenesis inhibitors. Casu, B., Guerrini, M., Naggi, A., Perez, M., Torri, G., Ribatti, D., Carminati, P., Giannini, G., Penco, S., Pisano, C., Belleri, M., Rusnati, M., Presta, M. Biochemistry (2002) [Pubmed]
  19. Fibroblast growth factor 2 regulation of mitral valve interstitial cell repair in vitro. Gotlieb, A.I., Rosenthal, A., Kazemian, P. J. Thorac. Cardiovasc. Surg. (2002) [Pubmed]
  20. Effects of L-arginine on the endogenous angiogenic response in a model of hypercholesterolemia. Nakai, Y., Voisine, P., Bianchi, C., Xu, S.H., Feng, J., Malik, T., Rosinberg, A., Sellke, F.W. Surgery (2005) [Pubmed]
  21. Round window application of D-methionine, sodium thiosulfate, brain-derived neurotrophic factor, and fibroblast growth factor-2 in cisplatin-induced ototoxicity. Wimmer, C., Mees, K., Stumpf, P., Welsch, U., Reichel, O., Suckfüll, M. Otol. Neurotol. (2004) [Pubmed]
 
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