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BDNF  -  brain-derived neurotrophic factor

Sus scrofa

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Disease relevance of BDNF


High impact information on BDNF


Biological context of BDNF

  • Results show that isolation rearing reduces hippocampal cell proliferation, likely by reducing BDNF expression and hampers migration of the new neurons to the granule cell layer, likely by altering density/morphology of radial glia cells [11].
  • In the hippocampus, CA2, CA3, and hilar, neurons demonstrated both BDNF- and TrkB-IR during development and maturation, whereas CA1 neurons showed TrkB-IR throughout this period but only transient BDNF-IR in early gestation [12].
  • Coincident elevation at 3 and 7 days of BDNF or NT-3 and phosphorylated extracellular signal-regulated protein kinase 2 (ERK2-P) suggested a relationship to stimulated signal transduction activity [1].
  • This experiment investigated the effect of a single intravenous (i.v.) injection of the synthetic glucocorticoid, dexamethasone (Dex, 5 mg kg(-1)) on gene expression for MR s, GR s, BDNF, trkB, and selected ionotropic glutamate receptor subunits (iGluRs), in the porcine hippocampus [13].
  • Down-regulation of BDNF mRNA, with no effect on trkB or glucocorticoid receptor m RNAs, in the porcine hippocampus after acute dexamethasone treatment [13].

Anatomical context of BDNF

  • Regulation of NT-3 and BDNF levels in guinea pig auditory brain stem nuclei after unilateral cochlear ablation [1].
  • The developmental increase in BDNF- and TrkB-IR in the neuropil of both structures coincided with periods of significant growth in all strata, indicating a role for BDNF and TrkB in process outgrowth [12].
  • In the postnatal period, BDNF-IR was down-regulated but TrkB-IR persisted, indicating that mature Purkinje cells might retain their responsiveness to BDNF [12].
  • BDNF levels were elevated transiently by 50% on the ablated side in the anteroventral (AVCN) and posteroventral (PVCN) cochlear nucleus at 3 days and may have signaled support for the survival of deafferented neurons [1].
  • BDNF had no protective effect on hair cells at 15 and 60 days, but some at 30 days [14].

Associations of BDNF with chemical compounds

  • This study suggests that NT-3 and BDNF may protect against cochlear hair cell damage caused by kanamycin treatment [14].
  • In contrast, a radical scavenger, D-methionine, or the neurotrophin BDNF suppressed the production of ROS, in turn stimulating NO production [15].
  • The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF [16].
  • The objective was to determine whether chronic glucocorticoid treatment would alter the expression of mRNAs for gluco- and mineralocorticoid receptors (GR and MR), brain-derived neurotrophic factor (BDNF), its receptor, trkB, and selected ionotropic glutamate receptor (iGluR) subunits in the hippocampus [17].
  • This result indicates that BDNF provides effective protection against inner ear damage and that biodegradable hydrogel is useful for application of drugs to the inner ear [18].

Other interactions of BDNF


Analytical, diagnostic and therapeutic context of BDNF


  1. Regulation of NT-3 and BDNF levels in guinea pig auditory brain stem nuclei after unilateral cochlear ablation. Suneja, S.K., Yan, L., Potashner, S.J. J. Neurosci. Res. (2005) [Pubmed]
  2. Delayed neurotrophin treatment supports auditory neuron survival in deaf guinea pigs. Gillespie, L.N., Clark, G.M., Marzella, P.L. Neuroreport (2004) [Pubmed]
  3. Adenovirus-mediated expression of brain-derived neurotrophic factor protects spiral ganglion neurons from ototoxic damage. Nakaizumi, T., Kawamoto, K., Minoda, R., Raphael, Y. Audiol. Neurootol. (2004) [Pubmed]
  4. The response of chick sensory neurons to brain-derived neurotrophic factor. Davies, A.M., Thoenen, H., Barde, Y.A. J. Neurosci. (1986) [Pubmed]
  5. Prenatally compromised neurons respond to brain-derived neurotrophic factor treatment in vitro. Briscoe, T.A., Tolcos, M., Dieni, S., Loeliger, M., Rees, S.M. Neuroreport (2006) [Pubmed]
  6. Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3. Ernfors, P., Duan, M.L., ElShamy, W.M., Canlon, B. Nat. Med. (1996) [Pubmed]
  7. Molecular cloning and expression of brain-derived neurotrophic factor. Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Thoenen, H., Barde, Y.A. Nature (1989) [Pubmed]
  8. Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function. Kopke, R.D., Jackson, R.L., Li, G., Rasmussen, M.D., Hoffer, M.E., Frenz, D.A., Costello, M., Schultheiss, P., Van De Water, T.R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Ernfors, P., Ibáñez, C.F., Ebendal, T., Olson, L., Persson, H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  10. Human platelets contain brain-derived neurotrophic factor. Yamamoto, H., Gurney, M.E. J. Neurosci. (1990) [Pubmed]
  11. Neonatal isolation impairs neurogenesis in thedentate gyrus of the guinea pig. Rizzi, S., Bianchi, P., Guidi, S., Ciani, E., Bartesaghi, R. Hippocampus (2007) [Pubmed]
  12. Distribution of brain-derived neurotrophic factor and TrkB receptor proteins in the fetal and postnatal hippocampus and cerebellum of the guinea pig. Dieni, S., Rees, S. J. Comp. Neurol. (2002) [Pubmed]
  13. Down-regulation of BDNF mRNA, with no effect on trkB or glucocorticoid receptor m RNAs, in the porcine hippocampus after acute dexamethasone treatment. Vellucci, S.V., Parrott, R.F., Mimmack, M.L. Res. Vet. Sci. (2001) [Pubmed]
  14. Effects of BDNF and NT-3 on hair cell survival in guinea pig cochlea damaged by kanamycin treatment. Ruan, R.S., Leong, S.K., Mark, I., Yeoh, K.H. Neuroreport (1999) [Pubmed]
  15. Simultaneous detection of both nitric oxide and reactive oxygen species in guinea pig vestibular sensory cells. Takumida, M., Anniko, M. ORL J. Otorhinolaryngol. Relat. Spec. (2002) [Pubmed]
  16. The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. Grider, J.R., Piland, B.E. Am. J. Physiol. Gastrointest. Liver Physiol. (2007) [Pubmed]
  17. Chronic dexamethasone-treatment alters mineralocorticoid receptor, truncated trkB and selected glutamate receptor subunit mRNA expression in the porcine hippocampus. Vellucci, S.V., Parrott, R.F., Mimmack, M.L. Neuropeptides (2002) [Pubmed]
  18. A new method for drug application to the inner ear. Ito, J., Endo, T., Nakagawa, T., Kita, T., Kim, T.S., Iguchi, F. ORL J. Otorhinolaryngol. Relat. Spec. (2005) [Pubmed]
  19. BDNF and TrkB protein expression is altered in the fetal hippocampus but not cerebellum after chronic prenatal compromise. Dieni, S., Rees, S. Exp. Neurol. (2005) [Pubmed]
  20. Round window application of D-methionine, sodium thiosulfate, brain-derived neurotrophic factor, and fibroblast growth factor-2 in cisplatin-induced ototoxicity. Wimmer, C., Mees, K., Stumpf, P., Welsch, U., Reichel, O., Suckfüll, M. Otol. Neurotol. (2004) [Pubmed]
  21. Adenoviral and adeno-associated viral vector mediated gene transfer in the guinea pig cochlea. Li Duan, M., Bordet, T., Mezzina, M., Kahn, A., Ulfendahl, M. Neuroreport (2002) [Pubmed]
  22. The effects of intra-vestibular nucleus administration of brain-derived neurotrophic factor (BDNF) on recovery from peripheral vestibular damage in guinea pig. Maingay, M.G., Sansom, A.J., Kerr, D.R., Smith, P.F., Darlington, C.L. Neuroreport (2000) [Pubmed]
  23. Unilateral vestibular deafferentation induces brain-derived neurotrophic factor (BDNF) protein expression in the guinea pig lateral but not medial vestibular nuclei. Smith, P.F., Darlington, C.L., Yan, Q., Dragunow, M. Journal of vestibular research : equilibrium & orientation. (1998) [Pubmed]
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