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Gene Review

VEGFA  -  vascular endothelial growth factor A

Sus scrofa

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Disease relevance of VEGFA


High impact information on VEGFA


Chemical compound and disease context of VEGFA


Biological context of VEGFA

  • Nevertheless, when treatments were associated, a reduction of LPS-induced apoptosis was always observed; the reduction was maximal when all the treatments (HS + Hemin + VEGF) were associated [13].
  • In conclusion, this study demonstrates that LPS is effective in evoking "the heat shock response" with an increase of nonspecific protective molecules (namely Hsp70 and Hsp32) and of VEGF, a specific EC growth factor [13].
  • VEGF upregulation in the proliferative zone after ischemic damage may play a role in stimulating vascular invasion and granulation tissue formation in the necrotic hypertrophic zone of the epiphyseal cartilage [14].
  • The objectives of the present study were to determine concentrations of VEGF in fetal blood and placental fluids as well as placental and adjacent endometrial mRNA expression of VEGF, VEGF-R1, and VEGF-R2 on Days 30, 50, 70, 90, and 110 of gestation in Yorkshire and Meishan pigs [15].
  • VEGF, VEGFR-1 and VEGFR-2 immunoreactivity in the porcine arteries of vascular subovarian plexus (VSP) during the estrous cycle [16].

Anatomical context of VEGFA

  • This study aimed at determining whether an LPS exposure is effective in inducing apoptosis in primary cultures of porcine aortic endothelial cells and in stimulating heat shock protein (Hsp)70 and Hsp32 production as well as vascular endothelial growth factor (VEGF) secretion [13].
  • This study suggests that VEGF facilitates the repair of the necrotic epiphyseal cartilage, which is essential for restoration of endochondral ossification and re-establishment of the growth of the immature femoral head after ischemic necrosis [14].
  • Differential expression of the vascular endothelial growth factor-receptor system in the gravid uterus of yorkshire and Meishan pigs [15].
  • Day 90 Meishan conceptuses exhibited marked increases (P < 0.05) in placental VEGF mRNA expression as well as fetal blood and allantoic fluid concentrations of VEGF, which remained elevated through Day 110 [15].
  • Our study revealed the presence of VEGF and its receptors in endothelial and smooth muscle cells of VSP arteries [16].

Associations of VEGFA with chemical compounds


Regulatory relationships of VEGFA


Other interactions of VEGFA


Analytical, diagnostic and therapeutic context of VEGFA


  1. Myocardial VEGF expression after cardiopulmonary bypass and cardioplegia. Tofukuji, M., Metais, C., Li, J., Franklin, A., Simons, M., Sellke, F.W. Circulation (1998) [Pubmed]
  2. Nicotine and cotinine up-regulate vascular endothelial growth factor expression in endothelial cells. Conklin, B.S., Zhao, W., Zhong, D.S., Chen, C. Am. J. Pathol. (2002) [Pubmed]
  3. Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment. Guo, P., Hu, B., Gu, W., Xu, L., Wang, D., Huang, H.J., Cavenee, W.K., Cheng, S.Y. Am. J. Pathol. (2003) [Pubmed]
  4. Normoxic wound fluid contains high levels of vascular endothelial growth factor. Howdieshell, T.R., Riegner, C., Gupta, V., Callaway, D., Grembowicz, K., Sathyanarayana, n.u.l.l., McNeil, P.L. Ann. Surg. (1998) [Pubmed]
  5. Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. Sato, K., Wu, T., Laham, R.J., Johnson, R.B., Douglas, P., Li, J., Sellke, F.W., Bunting, S., Simons, M., Post, M.J. J. Am. Coll. Cardiol. (2001) [Pubmed]
  6. Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function. Kreuger, J., Matsumoto, T., Vanwildemeersch, M., Sasaki, T., Timpl, R., Claesson-Welsh, L., Spillmann, D., Lindahl, U. EMBO J. (2002) [Pubmed]
  7. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration. Gille, H., Kowalski, J., Yu, L., Chen, H., Pisabarro, M.T., Davis-Smyth, T., Ferrara, N. EMBO J. (2000) [Pubmed]
  8. Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined with oral supplementation of l-arginine in a porcine model of endothelial dysfunction. Voisine, P., Bianchi, C., Khan, T.A., Ruel, M., Xu, S.H., Feng, J., Li, J., Malik, T., Rosinberg, A., Sellke, F.W. J. Thorac. Cardiovasc. Surg. (2005) [Pubmed]
  9. The effects of reduced oxygen tension on swine granulosa cell. Basini, G., Bianco, F., Grasselli, F., Tirelli, M., Bussolati, S., Tamanini, C. Regul. Pept. (2004) [Pubmed]
  10. In vitro effects of dexamethasone on hypoxia-induced hyperpermeability and expression of vascular endothelial growth factor. Fischer, S., Renz, D., Schaper, W., Karliczek, G.F. Eur. J. Pharmacol. (2001) [Pubmed]
  11. Barbiturates decrease the expression of vascular endothelial growth factor in hypoxic cultures of porcine brain derived microvascular endothelial cells. Fischer, S., Renz, D., Schaper, W., Karliczek, G.F. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  12. Inhibition of the cardiac angiogenic response to exogenous vascular endothelial growth factor. Voisine, P., Bianchi, C., Ruel, M., Malik, T., Rosinberg, A., Feng, J., Khan, T.A., Xu, S.H., Sandmeyer, J., Laham, R.J., Sellke, F.W. Surgery (2004) [Pubmed]
  13. Heat shock protein 70, heat shock protein 32, and vascular endothelial growth factor production and their effects on lipopolysaccharide-induced apoptosis in porcine aortic endothelial cells. Bernardini, C., Zannoni, A., Turba, M.E., Fantinati, P., Tamanini, C., Bacci, M.L., Forni, M. Cell Stress Chaperones (2005) [Pubmed]
  14. Increased VEGF expression in the epiphyseal cartilage after ischemic necrosis of the capital femoral epiphysis. Kim, H.K., Bian, H., Randall, T., Garces, A., Gerstenfeld, L.C., Einhorn, T.A. J. Bone Miner. Res. (2004) [Pubmed]
  15. Differential expression of the vascular endothelial growth factor-receptor system in the gravid uterus of yorkshire and Meishan pigs. Vonnahme, K.A., Ford, S.P. Biol. Reprod. (2004) [Pubmed]
  16. VEGF, VEGFR-1 and VEGFR-2 immunoreactivity in the porcine arteries of vascular subovarian plexus (VSP) during the estrous cycle. Postek, A., Andronowska, A., Doboszyńska, T., Niewegłowski, H., Jankowska, K. Folia Histochem. Cytobiol. (2006) [Pubmed]
  17. Nucleotide sequence and expression of the porcine vascular endothelial growth factor. Sharma, H.S., Tang, Z.H., Gho, B.C., Verdouw, P.D. Biochim. Biophys. Acta (1995) [Pubmed]
  18. VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase. Qi, J.H., Claesson-Welsh, L. Exp. Cell Res. (2001) [Pubmed]
  19. Effects of G-CSF on cardiac remodeling after acute myocardial infarction in swine. Iwanaga, K., Takano, H., Ohtsuka, M., Hasegawa, H., Zou, Y., Qin, Y., Odaka, K., Hiroshima, K., Tadokoro, H., Komuro, I. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  20. Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. Fuchs, S., Baffour, R., Zhou, Y.F., Shou, M., Pierre, A., Tio, F.O., Weissman, N.J., Leon, M.B., Epstein, S.E., Kornowski, R. J. Am. Coll. Cardiol. (2001) [Pubmed]
  21. Functional activation of heat shock factor and hypoxia-inducible factor in the kidney. Eickelberg, O., Seebach, F., Riordan, M., Thulin, G., Mann, A., Reidy, K.H., Van Why, S.K., Kashgarian, M., Siegel, N. J. Am. Soc. Nephrol. (2002) [Pubmed]
  22. Comprehensive evaluation of ureteral healing after electrosurgical endopyelotomy in a porcine model: original report and review of the literature. Andreoni, C.R., Lin, H.K., Olweny, E., Landman, J., Lee, D., Bostwick, D., Clayman, R.V. J. Urol. (2004) [Pubmed]
  23. Gene expression in a swine model of right ventricular hypertrophy: intercellular adhesion molecule, vascular endothelial growth factor and plasminogen activators are upregulated during pressure overload. Carroll, S.M., Nimmo, L.E., Knoepfler, P.S., White, F.C., Bloor, C.M. J. Mol. Cell. Cardiol. (1995) [Pubmed]
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