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Gene Review

VIM  -  vimentin

Sus scrofa

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Disease relevance of VIM


High impact information on VIM


Biological context of VIM


Anatomical context of VIM

  • The kidney originates from mesenchymal blastema, which changes to epithelium, losing VIM and acquiring CK expression [1].
  • Stromal cells expressed both VIM and actin, demonstrating myofibroblastic differentiation [1].
  • Here we characterize a large fragment of chicken gizzard and pig stomach desmin as well as the corresponding fragment from porcine eye lens vimentin [9].
  • These changes in the distribution of vimentin occurred in conjunction with reorganization of actin filaments [12].
  • Here, we demonstrate that the first stage in vimentin rearrangement during ASFV infection involves a microtubule-dependent concentration of vimentin into an "aster" within virus assembly sites located close to the microtubule organizing center [2].

Associations of VIM with chemical compounds

  • In addition, an increased tyrosine phosphorylation of vimentin was observed [12].
  • The solubility of vimentin upon Nonidet-P40-extraction of cells decreased considerably after PDGF stimulation, indicating that PDGF caused a redistribution of vimentin to a less soluble compartment [12].
  • Immunostaining showed that vimentin within the cage was phosphorylated on serine 82 [2].
  • After dialysis against 10 mM-Tris-acetate (pH 8.5), vimentin that has been purified in the presence of urea is present in the form of tetrameric 2 to 3 nm X 48 nm rods known as protofilaments [13].
  • Proliferating Müller cells were identified within the inner nuclear layer of retinal fragments as early as 2 days in culture using bromodeoxyuridine (BrdU) and vimentin double labeling [14].

Physical interactions of VIM


Other interactions of VIM


Analytical, diagnostic and therapeutic context of VIM


  1. Immunohistochemical study of porcine nephroblastoma. Grieco, V., Riccardi, E., Belotti, S., Scanziani, E. J. Comp. Pathol. (2006) [Pubmed]
  2. Vimentin rearrangement during African swine fever virus infection involves retrograde transport along microtubules and phosphorylation of vimentin by calcium calmodulin kinase II. Stefanovic, S., Windsor, M., Nagata, K.I., Inagaki, M., Wileman, T. J. Virol. (2005) [Pubmed]
  3. Cellular and cytoskeletal dynamics within organ cultures of porcine neuroretina. Winkler, J., Hagelstein, S., Rohde, M., Laqua, H. Exp. Eye Res. (2002) [Pubmed]
  4. Changing intermediate-sized filament patterns in metastatic hepatocellular carcinoma cells of the guinea pig. van de Molengraft, F., Ramaekers, F., Jap, P., Vooijs, P., Mungyer, G. Virchows Arch., B, Cell Pathol. (1986) [Pubmed]
  5. Immunocytochemical localization of intermediate filaments in the guinea pig vestibular periphery with special reference to their alteration after ototoxic drug administration. Usami, S., Hozawa, J., Shinkawa, H., Saito, S., Matsubara, A., Fujita, S. Acta oto-laryngologica. Supplementum. (1993) [Pubmed]
  6. Aggresomes resemble sites specialized for virus assembly. Heath, C.M., Windsor, M., Wileman, T. J. Cell Biol. (2001) [Pubmed]
  7. Adventitial remodeling after coronary arterial injury. Shi, Y., Pieniek, M., Fard, A., O'Brien, J., Mannion, J.D., Zalewski, A. Circulation (1996) [Pubmed]
  8. Primary and secondary structure of hamster vimentin predicted from the nucleotide sequence. Quax-Jeuken, Y.E., Quax, W.J., Bloemendal, H. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  9. Comparison of the proteins of two immunologically distinct intermediate-sized filaments by amino acid sequence analysis: desmin and vimentin. Geisler, N., Weber, K. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  10. Thrombin-induced vimentin phosphorylation in cultured human umbilical vein endothelial cells. Bormann, B.J., Huang, C.K., Lam, G.F., Jaffe, E.A. J. Biol. Chem. (1986) [Pubmed]
  11. Canine preprorelaxin: nucleic acid sequence and localization within the canine placenta. Klonisch, T., Hombach-Klonisch, S., Froehlich, C., Kauffold, J., Steger, K., Steinetz, B.G., Fischer, B. Biol. Reprod. (1999) [Pubmed]
  12. PDGF induces reorganization of vimentin filaments. Valgeirsdóttir, S., Claesson-Welsh, L., Bongcam-Rudloff, E., Hellman, U., Westermark, B., Heldin, C.H. J. Cell. Sci. (1998) [Pubmed]
  13. Assembly of vimentin in vitro and its implications concerning the structure of intermediate filaments. Ip, W., Hartzer, M.K., Pang, Y.Y., Robson, R.M. J. Mol. Biol. (1985) [Pubmed]
  14. Response of Müller cells to growth factors alters with time in culture. Small, R.K., Patel, P., Watkins, B.A. Glia (1991) [Pubmed]
  15. Astrocytes in the guinea pig, horse, and monkey retina: their occurrence coincides with the presence of blood vessels. Schnitzer, J. Glia (1988) [Pubmed]
  16. Transforming growth factor-beta1 induces a mesenchyme-like cell shape without epithelial polarization in thyrocytes and inhibits thyroid folliculogenesis in collagen gel culture. Toda, S., Matsumura, S., Fujitani, N., Nishimura, T., Yonemitsu, N., Sugihara, H. Endocrinology (1997) [Pubmed]
  17. Glucose metabolism in freshly isolated Müller glial cells from a mammalian retina. Poitry-Yamate, C.L., Tsacopoulos, M. J. Comp. Neurol. (1992) [Pubmed]
  18. Localization of aminopeptidase N and dipeptidyl peptidase IV in pig striatum and in neuronal and glial cell cultures. Barnes, K., Kenny, A.J., Turner, A.J. Eur. J. Neurosci. (1994) [Pubmed]
  19. Shear stress facilitates tissue-engineered odontogenesis. Honda, M.J., Shinohara, Y., Sumita, Y., Tonomura, A., Kagami, H., Ueda, M. Bone (2006) [Pubmed]
  20. Neonatal isolation impairs neurogenesis in thedentate gyrus of the guinea pig. Rizzi, S., Bianchi, P., Guidi, S., Ciani, E., Bartesaghi, R. Hippocampus (2007) [Pubmed]
  21. Isolation and characterization of a feeder-dependent, porcine trophectoderm cell line obtained from a 9-day blastocyst. Fléchon, J.E., Laurie, S., Notarianni, E. Placenta (1995) [Pubmed]
  22. Ultrastructural immunogold localization of vimentin and S-100 protein in guinea pig pars tuberalis. Kameda, Y. J. Histochem. Cytochem. (1996) [Pubmed]
  23. Immunocytochemistry of intermediate filaments in cultured arterial smooth muscle cells: differences in desmin and vimentin expression related to cell of origin and/or plating time. Sakata, N., Kawamura, K., Fujimitsu, K., Chiang, Y.Y., Takebayashi, S. Exp. Mol. Pathol. (1990) [Pubmed]
  24. Morphological and functional characteristics of the different cell types in the stria vascularis: a comparison between cells obtained from fresh tissue preparations and cells cultured in vitro. Agrup, C., Berggren, P.O., Köhler, M., Spångberg, M.L., Bagger-Sjöbäck, D. Hear. Res. (1996) [Pubmed]
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