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Gene Review

NGFR  -  nerve growth factor receptor

Gallus gallus

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Disease relevance of NGFR

  • NGFR expression in the chick otocyst and acoustic ganglion is compared with epithelial differentiation and the onset of afferent innervation as determined with fluorescent carbocyanine tracers [1].
  • Non-neuronal drg cells obtained by a procedure designed for the preparation of pure Schwann cells, as well as RN6 Schwannoma cells, were beta NGF receptor positive [2].

High impact information on NGFR


Biological context of NGFR


Anatomical context of NGFR

  • NGFR mRNA expression is detected in premigratory neural crest cells, in epibranchial placode cells, and in all sensory, sympathetic and parasympathetic derivatives of these structures [6].
  • NGFR mRNA also is transiently expressed in many mesenchymal cell populations including cells in branchial arch, sclerotome, muscle anlagen, and feather follicles [6].
  • By Embryonic Day 8, NGFR mRNA is detected in a substantial fraction of cells in every brain region, with highest levels present in developing motor neurons [6].
  • The acoustic ganglia remain weakly NGFR mRNA-labeled in the posthatch animal [1].
  • In the otocyst epithelium, NGFR mRNA expression develops in one anterior and one posterior focus at E3-4 [1].

Associations of NGFR with chemical compounds

  • 5. NGFR mRNA is expressed in the primordia of the ampullary cristae (E5-7) and possibly the anlage of the utricle; label transiently concentrates in the planum semilunatum of the cristae ampullares and in superior portions of the semicircular canals at E9, but is not seen in differentiating hair cells [1].
  • Analyses of NGFR levels in subpopulations of E6 and E8 lumbar cord cells, prepared by metrizamide density gradient centrifugation, showed that during this period there is an enrichment of both types of NGFRs in the motoneuron-containing subpopulation, relative to other cell populations [8].

Other interactions of NGFR

  • Brain-derived neurotrophic factor is a ligand for the low-affinity NGF receptor, p75, and for the high-affinity neurotrophin receptor, trkB [9].
  • To analyze how motoneurons acquire regional specification along the anterior-posterior (A-P) axis and in the transverse plane, we observed the expression of Cek8, Islet-1, SC1 and low-affinity NGF receptor on ectopic motoneurons induced by implanting a supernumerary notochord or floor plate [10].

Analytical, diagnostic and therapeutic context of NGFR


  1. Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat. von Bartheld, C.S., Patterson, S.L., Heuer, J.G., Wheeler, E.F., Bothwell, M., Rubel, E.W. Development (1991) [Pubmed]
  2. beta-Nerve growth factor (beta NGF) receptors on glial cells. Cell-cell interaction between neurones and Schwann cells in cultures of chick sensory ganglia. Zimmermann, A., Sutter, A. EMBO J. (1983) [Pubmed]
  3. Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system. Heuer, J.G., von Bartheld, C.S., Kinoshita, Y., Evers, P.C., Bothwell, M. Neuron (1990) [Pubmed]
  4. Developmental and regional expression of beta-nerve growth factor receptor mRNA in the chick and rat. Ernfors, P., Hallböök, F., Ebendal, T., Shooter, E.M., Radeke, M.J., Misko, T.P., Persson, H. Neuron (1988) [Pubmed]
  5. The spatial and temporal pattern of beta NGF receptor expression in the developing chick embryo. Raivich, G., Zimmermann, A., Sutter, A. EMBO J. (1985) [Pubmed]
  6. Structure and developmental expression of the chicken NGF receptor. Heuer, J.G., Fatemie-Nainie, S., Wheeler, E.F., Bothwell, M. Dev. Biol. (1990) [Pubmed]
  7. Expression of nerve growth factor (NGF) receptors in the brain and retina of chick embryos: comparison with cholinergic development. von Bartheld, C.S., Heuer, J.G., Bothwell, M. J. Comp. Neurol. (1991) [Pubmed]
  8. Ontogeny of high- and low-affinity nerve growth factor receptors in the lumbar spinal cord of the developing chick embryo. Marchetti, D., Haverkamp, L.J., Clark, R.C., McManaman, J.L. Dev. Biol. (1991) [Pubmed]
  9. The expression of trkB and p75 and the role of BDNF in the developing neuromuscular system of the chick embryo. McKay, S.E., Garner, A., Caldero, J., Tucker, R.P., Large, T., Oppenheim, R.W. Development (1996) [Pubmed]
  10. Commitment of motoneuron progenitors of chick embryo along the anterior-posterior axis. Tanaka, H., Fukushima, M., Ohta, K., Kimura, Y., Sudo, A., Shirabe, K., Takeshita, M. Dev. Neurosci. (1997) [Pubmed]
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