Gene Review:
DHFR - dihydrofolate reductase
Gallus gallus
- 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes. Roth, B., Rauckman, B.S., Ferone, R., Baccanari, D.P., Champness, J.N., Hyde, R.M. J. Med. Chem. (1987)
- On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships. Selassie, C.D., Fang, Z.X., Li, R.L., Hansch, C., Debnath, G., Klein, T.E., Langridge, R., Kaufman, B.T. J. Med. Chem. (1989)
- Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim. Matthews, D.A., Bolin, J.T., Burridge, J.M., Filman, D.J., Volz, K.W., Kaufman, B.T., Beddell, C.R., Champness, J.N., Stammers, D.K., Kraut, J. J. Biol. Chem. (1985)
- Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: calorimetric and spectroscopic binding studies. Subramanian, S., Kaufman, B.T. Proc. Natl. Acad. Sci. U.S.A. (1978)
- Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase. Kumar, P., Kisliuk, R.L., Gaumont, Y., Nair, M.G., Baugh, C.M., Kaufman, B.T. Cancer Res. (1986)
- 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogues with high activity and specificity for bacterial dihydrofolate reductase. Johnson, J.V., Rauchman, B.S., Baccanari, D.P., Roth, B. J. Med. Chem. (1989)
- 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity. Roth, B., Aig, E. J. Med. Chem. (1987)
- The electrostatic potential of Escherichia coli dihydrofolate reductase. Bajorath, J., Kitson, D.H., Kraut, J., Hagler, A.T. Proteins (1991)
- Dihydrofolate reductases from chicken liver and Lactobacillus casei bind Cibacron blue F3GA in different modes and at different sites. Subramanian, S., Kaufman, B.T. J. Biol. Chem. (1980)
- Activation of chicken liver dihydrofolate reductase by urea and guanidine hydrochloride is accompanied by conformational change at the active site. Fan, Y.X., Ju, M., Zhou, J.M., Tsou, C.L. Biochem. J. (1996)
- Synthesis of quaternised 2-aminopyrimido[4,5-d]pyrimidin-4(3H)-ones and their biological activity with dihydrofolate reductase. Gebauer, M.G., McKinlay, C., Gready, J.E. European journal of medicinal chemistry. (2003)
- Lanthanide ions inhibit the activity of dihydrofolate reductase from chicken liver. Wu, Y. Biometals (2000)
- Structural features of the murine dihydrofolate reductase transcription termination region: identification of a conserved DNA sequence element. Frayne, E.G., Kellems, R.E. Nucleic Acids Res. (1986)
- Computer-aided drug design: a free energy perturbation study on the binding of methyl-substituted pterins and N5-deazapterins to dihydrofolate reductase. Cummins, P.L., Gready, J.E. J. Comput. Aided Mol. Des. (1993)
- Relation between some folate-dependent metabolic pathways and dietary folate content in chicks. Whitehead, C.C., Rennie, J.S. Br. J. Nutr. (1989)
- Dihydrofolate reductase from Eimeria tenella: rationalization of chemotherapeutic efficacy of pyrimethamine. Wang, C.C., Stotish, R.L., Poe, M. J. Protozool. (1975)
- Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin. McTigue, M.A., Davies, J.F., Kaufman, B.T., Kraut, J. Biochemistry (1992)
- Ligand-induced conformational changes of GroEL are dependent on the bound substrate polypeptide. Mendoza, J.A., Campo, G.D. J. Biol. Chem. (1996)
- Highly fluctuating protein structures revealed by variable-pressure nuclear magnetic resonance. Akasaka, K. Biochemistry (2003)
- Determination of the conformation of trimethoprim in the binding pocket of bovine dihydrofolate reductase from a STD-NMR intensity-restrained CORCEMA-ST optimization. Jayalakshmi, V., Krishna, N.R. J. Am. Chem. Soc. (2005)
- Circular dichroism studies in the near UV of ligand binding to chicken liver dihydrofolate reductase. Seng, G., Bolard, J. Biochimie (1983)
- Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry. Nikolic, D., van Breemen, R.B. Comb. Chem. High Throughput Screen. (1998)
- Characterization of chicken liver dihydrofolate reductase after purification by affinity chromatography and isoelectric focusing. Kaufman, B.T., Kemerer, V.F. Arch. Biochem. Biophys. (1977)