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Gene Review

GFAP  -  glial fibrillary acidic protein

Ovis aries

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Disease relevance of GFAP


High impact information on GFAP


Chemical compound and disease context of GFAP


Biological context of GFAP


Anatomical context of GFAP


Associations of GFAP with chemical compounds


Other interactions of GFAP

  • GLT1 protein expression within astrocytes is developmentally regulated, appearing first in vimentin positive radial glia at 60 and 71 days and then switching to GFAP positive parenchymal and perivascular astrocytes at 136 days [18].
  • Immunolabelling with the nerve fibre markers PgP 9.5 and neuron-specific enolase and the satellite cell marker glial fibrillary acidic protein revealed the extensive ganglionated networks of the myenteric and submucosal plexi [19].

Analytical, diagnostic and therapeutic context of GFAP


  1. White matter injury after cerebral ischemia in ovine fetuses. Petersson, K.H., Pinar, H., Stopa, E.G., Faris, R.A., Sadowska, G.B., Hanumara, R.C., Stonestreet, B.S. Pediatr. Res. (2002) [Pubmed]
  2. Expression of glial fibrillary acidic protein and glutamine synthetase genes in the natural scrapie of sheep. Andres-Barquin, P.J., Le Prince, G., Fages, C., Garcia de Jalon, J.A., Pérez-Martos, A., Tardy, M., López-Pérez, M.J. Mol. Chem. Neuropathol. (1994) [Pubmed]
  3. Effects of chronic placental insufficiency on brain development in fetal sheep. Mallard, E.C., Rees, S., Stringer, M., Cock, M.L., Harding, R. Pediatr. Res. (1998) [Pubmed]
  4. Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentally induced placental insufficiency. Nicholls, T., Lacey, B., Nitsos, I., Smythe, G., Walker, D.W. Am. J. Obstet. Gynecol. (2001) [Pubmed]
  5. Insulin-like growth factor-1 reduces postischemic white matter injury in fetal sheep. Guan, J., Bennet, L., George, S., Wu, D., Waldvogel, H.J., Gluckman, P.D., Faull, R.L., Crosier, P.S., Gunn, A.J. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  6. A combined immunohistochemical and electron microscopic study of the second cell type in the developing sheep pineal gland. Franco, A., Regodon, S., Masot, A.J., Redondo, E. J. Pineal Res. (1997) [Pubmed]
  7. The primary structure of component 8c-1, a subunit protein of intermediate filaments in wool keratin. Relationships with proteins from other intermediate filaments. Dowling, L.M., Crewther, W.G., Inglis, A.S. Biochem. J. (1986) [Pubmed]
  8. Quinolinic acid promotes albumin deposition in Purkinje cell, astrocytic activation and lipid peroxidation in fetal brain. Yan, E., Castillo-Meléndez, M., Smythe, G., Walker, D. Neuroscience (2005) [Pubmed]
  9. Differential gene expression in central nervous system tissues of sheep with natural scrapie. Garcia-Crespo, D., Juste, R.A., Hurtado, A. Brain Res. (2006) [Pubmed]
  10. An immunohistochemical study of the fetal sheep neocortex and cerebellum with antibodies against nervous system-specific proteins. Hewicker-Trautwein, M., Trautwein, G. J. Comp. Pathol. (1993) [Pubmed]
  11. Pathological findings in retina and visual pathways associated to natural Scrapie in sheep. Hortells, P., Monzón, M., Monleón, E., Acín, C., Vargas, A., Bolea, R., Luján, L., Badiola, J.J. Brain Res. (2006) [Pubmed]
  12. Immunocytochemical localization of border disease virus in the spinal cord of fetal and newborn lambs. Jeffrey, M., Wells, G.A., Bridges, A.W., Sands, J.J. Neuropathol. Appl. Neurobiol. (1990) [Pubmed]
  13. Repeated prenatal corticosteroid administration delays astrocyte and capillary tight junction maturation in fetal sheep. Huang, W.L., Harper, C.G., Evans, S.F., Newnham, J.P., Dunlop, S.A. Int. J. Dev. Neurosci. (2001) [Pubmed]
  14. Localization of p450scc and 5alpha-reductase type-2 in the cerebellum of fetal and newborn sheep. Petratos, S., Hirst, J.J., Mendis, S., Anikijenko, P., Walker, D.W. Brain Res. Dev. Brain Res. (2000) [Pubmed]
  15. Tropism of border disease virus for oligodendrocytes in ovine fetal brain cell cultures. Anderson, C.A., Higgins, R.J., Waldvogel, A.S., Osburn, B.I. Am. J. Vet. Res. (1987) [Pubmed]
  16. Increased nerve and blood vessel ingrowth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration. Melrose, J., Roberts, S., Smith, S., Menage, J., Ghosh, P. Spine. (2002) [Pubmed]
  17. Brain damage and hypoxia in an ovine fetal chronic cocaine model. Laurini, R.N., Arbeille, B., Gemberg, C., Akoka, S., Locatelli, A., Lansac, J., Arbeille, P. Eur. J. Obstet. Gynecol. Reprod. Biol. (1999) [Pubmed]
  18. GLT1, glial glutamate transporter, is transiently expressed in neurons and develops astrocyte specificity only after midgestation in the ovine fetal brain. Northington, F.J., Traystman, R.J., Koehler, R.C., Martin, L.J. J. Neurobiol. (1999) [Pubmed]
  19. Disease-associated PrP in the enteric nervous system of scrapie-affected Suffolk sheep. Heggebø, R., González, L., Press, C.M., Gunnes, G., Espenes, A., Jeffrey, M. J. Gen. Virol. (2003) [Pubmed]
  20. Astroglial reactivity in natural scrapie of sheep. Lefrançois, T., Fages, C., Brugère-Picoux, J., Tardy, M. Microb. Pathog. (1994) [Pubmed]
  21. Repeated prenatal corticosteroids reduce glial fibrillary acidic protein in the ovine central nervous system. Quinlivan, J.A., Beazley, L.D., Archer, M., Evans, S.F., Newnham, J.P., Dunlop, S.A. Journal of perinatal medicine. (2002) [Pubmed]
  22. Quantification of glial fibrillary acidic protein in developing sheep brain cortex, cerebellum and stem. Andrés-Barquín, P.J., Pérez-Martos, A., López-Pérez, M.J. Comp. Biochem. Physiol., B (1991) [Pubmed]
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