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Gene Review

ZFHX3  -  zinc finger homeobox 3

Homo sapiens

Synonyms: AT motif-binding factor 1, AT-binding transcription factor 1, ATBF1, ATBT, Alpha-fetoprotein enhancer-binding protein, ...
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Disease relevance of ATBF1


High impact information on ATBF1


Biological context of ATBF1

  • We have isolated a full-length cDNA encoding a protein (ATBF1) that binds to an AT-rich motif in the human alpha-fetoprotein gene enhancer [8].
  • Recently, it has been reported that ATBF1 regulates myoblastic differentiation and interacts with v-Myb in regulation of its transactivation [9].
  • We present here experimental evidence that ATBF1 is a new regulatory factor for STAT3-mediated signal transduction through its interaction with PIAS3 [9].
  • ATBF1 is a 306-kDa protein containing four homeodomains, 17 zinc finger motifs, and several segments potentially involved in transcriptional regulation (T. Morinaga, H. Yasuda, T. Hashimoto, K. Higashio, and T. Tamaoki, Mol. Cell. Biol. 11:6041-6049, 1991) [10].
  • CAT assays showed the direct inhibition of AFP gene expression by ATBF1 [5].

Anatomical context of ATBF1


Associations of ATBF1 with chemical compounds

  • There was a positive correlation (P less than 0.001) between ATBF and serum T3 and T4 levels and an inverse correlation (P less than 0.01) between ATBF and plasma norepinephrine levels [12].
  • Endurance training alone did not affect subcutaneous abdominal adipose tissue lipolysis either at rest or during exercise, as reflected by identical levels of interstitial adipose tissue glycerol, subcutaneous abdominal ATBF, and plasma nonesterified fatty acids before and after completion of the training program [13].

Physical interactions of ATBF1

  • In co-transfection experiments, the full-length ATBF1 was found to form complexes with PIAS3 in Hep G2 cells [9].

Regulatory relationships of ATBF1

  • In conclusion, ATBF1 can suppress the IL-6-mediated cellular response by acting together with PIAS3 [9].
  • Taken together, these results corroborated the previous reports that ATBF1 regulated AFP expression and inhibited transcription [2].

Other interactions of ATBF1


Analytical, diagnostic and therapeutic context of ATBF1


  1. ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer. Zhang, Z., Yamashita, H., Toyama, T., Sugiura, H., Ando, Y., Mita, K., Hamaguchi, M., Kawaguchi, M., Miura, Y., Iwase, H. Clin. Cancer Res. (2005) [Pubmed]
  2. Alteration of the AT motif binding factor-1 expression in alpha-fetoprotein producing gastric cancer: is it an event for differentiation and proliferation of the tumors? Iida, M., Imura, J., Furuichi, T., Sawada, T., Nagawa, H., Fujimori, T. Oncol. Rep. (2004) [Pubmed]
  3. Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer. Sun, X., Frierson, H.F., Chen, C., Li, C., Ran, Q., Otto, K.B., Cantarel, B.L., Cantarel, B.M., Vessella, R.L., Gao, A.C., Petros, J., Miura, Y., Simons, J.W., Dong, J.T. Nat. Genet. (2005) [Pubmed]
  4. Regulation of the alpha-fetoprotein gene by the isoforms of ATBF1 transcription factor in human hepatoma. Ninomiya, T., Mihara, K., Fushimi, K., Hayashi, Y., Hashimoto-Tamaoki, T., Tamaoki, T. Hepatology (2002) [Pubmed]
  5. Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1. Kataoka, H., Miura, Y., Joh, T., Seno, K., Tada, T., Tamaoki, T., Nakabayashi, H., Kawaguchi, M., Asai, K., Kato, T., Itoh, M. Oncogene (2001) [Pubmed]
  6. Lactate release from the subcutaneous tissue in lean and obese men. Jansson, P.A., Larsson, A., Smith, U., Lönnroth, P. J. Clin. Invest. (1994) [Pubmed]
  7. Glycerol production in subcutaneous adipose tissue in lean and obese humans. Jansson, P.A., Larsson, A., Smith, U., Lönnroth, P. J. Clin. Invest. (1992) [Pubmed]
  8. A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers. Morinaga, T., Yasuda, H., Hashimoto, T., Higashio, K., Tamaoki, T. Mol. Cell. Biol. (1991) [Pubmed]
  9. ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. Nojiri, S., Joh, T., Miura, Y., Sakata, N., Nomura, T., Nakao, H., Sobue, S., Ohara, H., Asai, K., Ito, M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  10. ATBF1, a multiple-homeodomain zinc finger protein, selectively down-regulates AT-rich elements of the human alpha-fetoprotein gene. Yasuda, H., Mizuno, A., Tamaoki, T., Morinaga, T. Mol. Cell. Biol. (1994) [Pubmed]
  11. Expression of homeobox genes in cervical cancer. Li, H., Huang, C.J., Choo, K.B. Gynecol. Oncol. (2002) [Pubmed]
  12. Influence of hyper- and hypothyroidism on subcutaneous adipose tissue blood flow in man. Wennlund, A., Linde, B. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
  13. Endurance training and GH administration in elderly women: effects on abdominal adipose tissue lipolysis. Lange, K.H., Lorentsen, J., Isaksson, F., Juul, A., Rasmussen, M.H., Christensen, N.J., Bülow, J., Kjaer, M. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  14. Susceptibility to killer T cells of gastric cancer cells enhanced by Mitomycin-C involves induction of ATBF1 and activation of p21 (Waf1/Cip1) promoter. Miura, Y., Kataoka, H., Joh, T., Tada, T., Asai, K., Nakanishi, M., Okada, N., Okada, H. Microbiol. Immunol. (2004) [Pubmed]
  15. Translocation-excision-deletion-amplification mechanism leading to nonsyntenic coamplification of MYC and ATBF1. Van Roy, N., Vandesompele, J., Menten, B., Nilsson, H., De Smet, E., Rocchi, M., De Paepe, A., Påhlman, S., Speleman, F. Genes Chromosomes Cancer (2006) [Pubmed]
  16. Cloning of the cDNA encoding the mouse ATBF1 transcription factor. Ido, A., Miura, Y., Watanabe, M., Sakai, M., Inoue, Y., Miki, T., Hashimoto, T., Morinaga, T., Nishi, S., Tamaoki, T. Gene (1996) [Pubmed]
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