Gene Review:
Timp1 - TIMP metallopeptidase inhibitor 1
Rattus norvegicus
Synonyms:
Metalloproteinase inhibitor 1, TIMP-1, Timp, Timp-1, Tissue inhibitor of metalloproteinases 1
Roeb,
Purucker,
Gartung,
Geier,
Jansen,
Winograd,
Matern,
Rivera,
Ogier,
Jourquin,
Timsit,
Szklarczyk,
Miller,
Gearing,
Kaczmarek,
Khrestchatisky,
Curry,
Song,
Wheeler,
Soo,
Shaw,
Zhang,
Longaker,
Howard,
Ting,
Tasci,
Mas,
Vural,
Comert,
Alcigir,
Serdar,
Mas,
Isik,
Ates,
Di Sario,
Bendia,
Macarri,
Candelaresi,
Taffetani,
Marzioni,
Omenetti,
De Minicis,
Trozzi,
Benedetti,
Peterson,
Li,
Dillon,
Bryant,
- Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis. Kossakowska, A.E., Edwards, D.R., Lee, S.S., Urbanski, L.S., Stabbler, A.L., Zhang, C.L., Phillips, B.W., Zhang, Y., Urbanski, S.J. Am. J. Pathol. (1998)
- Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson, J.T., Li, H., Dillon, L., Bryant, J.W. Cardiovasc. Res. (2000)
- Gelatinase B and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia. Rivera, S., Ogier, C., Jourquin, J., Timsit, S., Szklarczyk, A.W., Miller, K., Gearing, A.J., Kaczmarek, L., Khrestchatisky, M. Eur. J. Neurosci. (2002)
- Differential expression of extracellular matrix remodeling genes in rat model of hemorrhagic shock and resuscitation. Chen, H., Inocencio, R., Alam, H.B., Rhee, P., Koustova, E. J. Surg. Res. (2005)
- Identification of a stimulator of steroid hormone synthesis isolated from testis. Boujrad, N., Ogwuegbu, S.O., Garnier, M., Lee, C.H., Martin, B.M., Papadopoulos, V. Science (1995)
- Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. Iredale, J.P., Benyon, R.C., Pickering, J., McCullen, M., Northrop, M., Pawley, S., Hovell, C., Arthur, M.J. J. Clin. Invest. (1998)
- Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model. Allaire, E., Forough, R., Clowes, M., Starcher, B., Clowes, A.W. J. Clin. Invest. (1998)
- Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis. Baker, A.H., Zaltsman, A.B., George, S.J., Newby, A.C. J. Clin. Invest. (1998)
- Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: association with arrested alveolarization. Hosford, G.E., Fang, X., Olson, D.M. Pediatr. Res. (2004)
- Rat liver fibrosis regresses better with pegylated interferon alpha2b and ursodeoxycholic acid treatments than spontaneous recovery. Tasci, I., Mas, M.R., Vural, S.A., Comert, B., Alcigir, G., Serdar, M., Mas, N., Isik, A.T., Ates, Y. Liver Int. (2006)
- Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis. Arthur, M.J., Mann, D.A., Iredale, J.P. J. Gastroenterol. Hepatol. (1998)
- Effect of glutathione depletion and hydrophilic bile acids on hepatic acute phase reaction in rats with extrahepatic cholestasis. Roeb, E., Purucker, E., Gartung, C., Geier, A., Jansen, B., Winograd, R., Matern, S. Scand. J. Gastroenterol. (2003)
- The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen alpha1(I), TIMP-1 and MMP-2. Di Sario, A., Bendia, E., Macarri, G., Candelaresi, C., Taffetani, S., Marzioni, M., Omenetti, A., De Minicis, S., Trozzi, L., Benedetti, A. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. (2004)
- Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Phillips, P.A., McCarroll, J.A., Park, S., Wu, M.J., Pirola, R., Korsten, M., Wilson, J.S., Apte, M.V. Gut (2003)
- Unbalanced collagenases/TIMP-1 expression and epithelial apoptosis in experimental lung fibrosis. Ruiz, V., Ordóñez, R.M., Berumen, J., Ramírez, R., Uhal, B., Becerril, C., Pardo, A., Selman, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2003)
- Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts. Varghese, S., Yu, K., Canalis, E. Am. J. Physiol. (1999)
- Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-beta1. Knittel, T., Mehde, M., Kobold, D., Saile, B., Dinter, C., Ramadori, G. J. Hepatol. (1999)
- Cellular localization of gelatinases and tissue inhibitors of metalloproteinases during follicular growth, ovulation, and early luteal formation in the rat. Curry, T.E., Song, L., Wheeler, S.E. Biol. Reprod. (2001)
- Expression of matrix metalloproteinase -2, -9 and tissue inhibitors of metalloproteinase -1, -2, -3 mRNAs in rat uterus during early pregnancy. Zhao, Y.G., Xiao, A.Z., Cao, X.M., Zhu, C. Mol. Reprod. Dev. (2002)
- Gelatinases A and B are up-regulated in rat lungs by subacute hyperoxia: pathogenetic implications. Pardo, A., Barrios, R., Maldonado, V., Meléndez, J., Pérez, J., Ruiz, V., Segura-Valdez, L., Sznajder, J.I., Selman, M. Am. J. Pathol. (1998)
- Terazosin modifies the content of glycosaminoglycans and the activity of matrix metalloproteinase 2 in the rat ventral prostate. Mitropoulos, D., Papakonstantinou, E., Aletras, A.J., Kalinderis, N., Zervas, A., Hatzichristou, D., Karakiulakis, G. Eur. Urol. (2007)
- Effects of benazepril on renal function and kidney expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in diabetic rats. Sun, S.Z., Wang, Y., Li, Q., Tian, Y.J., Liu, M.H., Yu, Y.H. Chin. Med. J. (2006)
- Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinases. McLennan, S.V., Kelly, D.J., Cox, A.J., Cao, Z., Lyons, J.G., Yue, D.K., Gilbert, R.E. Diabetologia (2002)
- Low dose pirfenidone suppresses transforming growth factor beta-1 and tissue inhibitor of metalloproteinase-1, and protects rats from lung fibrosis induced by bleomycina. Tian, X.L., Yao, W., Guo, Z.J., Gu, L., Zhu, Y.J. Chin. Med. Sci. J. (2006)
- Induction of cell death in activated hepatic stellate cells by targeted gene expression of the thymidine kinase/ganciclovir system. Janoschek, N., van de Leur, E., Gressner, A.M., Weiskirchen, R. Biochem. Biophys. Res. Commun. (2004)
- Follicle-stimulating hormone increases the expression of tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 and induces TIMP-1 AP-1 site binding complex(es) in prepubertal rat Sertoli cells. Ulisse, S., Farina, A.R., Piersanti, D., Tiberio, A., Cappabianca, L., D'Orazi, G., Jannini, E.A., Malykh, O., Stetler-Stevenson, W.G., D'Armiento, M. Endocrinology (1994)
- Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. Maitra, S.R., Shapiro, M.J., Bhaduri, S., El-Maghrabi, M.R. Crit. Care Med. (2005)
- Transforming growth factor beta1 inhibits collagenase 3 expression by transcriptional and post-transcriptional mechanisms in osteoblast cultures. Rydziel, S., Varghese, S., Canalis, E. J. Cell. Physiol. (1997)
- Inhibitory Effect of Emodin on Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Expression in Rat Hepatic Stellate Cells. Gui, M., Zhang, Y.F., Xiao, Z.Y., Sun, P., Dai, J.F., Wang, S.F., Rui, Y.C., Zhang, J.P. Dig. Dis. Sci. (2007)
- Insulin-like growth factors inhibit interstitial collagenase synthesis in bone cell cultures. Canalis, E., Rydziel, S., Delany, A.M., Varghese, S., Jeffrey, J.J. Endocrinology (1995)
- Scarless fetal wounds are associated with an increased matrix metalloproteinase-to-tissue-derived inhibitor of metalloproteinase ratio. Dang, C.M., Beanes, S.R., Lee, H., Zhang, X., Soo, C., Ting, K. Plast. Reconstr. Surg. (2003)
- Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL-10. Zheng, W.D., Zhang, L.J., Shi, M.N., Chen, Z.X., Chen, Y.X., Huang, Y.H., Wang, X.Z. World J. Gastroenterol. (2005)
- Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat. Knittel, T., Mehde, M., Grundmann, A., Saile, B., Scharf, J.G., Ramadori, G. Histochem. Cell Biol. (2000)
- Low protein diet blunts the rise in glomerular gene expression in focal glomerulosclerosis. Nakamura, T., Fukui, M., Ebihara, I., Tomino, Y., Koide, H. Kidney Int. (1994)
- Vitamin A deficiency alters the structure and collagen IV composition of rat renal basement membranes. Marín, M.P., Esteban-Pretel, G., Alonso, R., Sado, Y., Barber, T., Renau-Piqueras, J., Timoneda, J. J. Nutr. (2005)
- Differential expression of matrix metalloproteinases and their tissue-derived inhibitors in cutaneous wound repair. Soo, C., Shaw, W.W., Zhang, X., Longaker, M.T., Howard, E.W., Ting, K. Plast. Reconstr. Surg. (2000)
- Differential mRNA expression of renal cortical tissue inhibitor of metalloproteinase-1, -2, and -3 in experimental hydronephrosis. Engelmyer, E., van Goor, H., Edwards, D.R., Diamond, J.R. J. Am. Soc. Nephrol. (1995)