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BLOC1S2  -  biogenesis of lysosomal organelles complex...

Homo sapiens

Synonyms: BLOC-1 subunit 2, BLOS2, Biogenesis of lysosome-related organelles complex 1 subunit 2, CEAP, CEAP11, ...
 
 
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Disease relevance of BLOC1S2

 

High impact information on BLOC1S2

 

Biological context of BLOC1S2

 

Anatomical context of BLOC1S2

 

Associations of BLOC1S2 with chemical compounds

  • Ultrastructural studies showed that PMN incubated in f-met-leu-phe, taxol, or both had increased (p less than 0.001) numbers of centrosome-associated microtubules, and the microtubules of cells incubated in taxol with or without f-met-leu-phe were organized into bundles [16].
  • The centrosome-associated Aurora/Ipl-like kinase family [17].
  • CVI clinical severity was classified according to CEAP as C2&C3 (mild disease), C4 (moderate disease), and C5&C6 (severe disease) [4].
  • METHODS: The study included 121 patients with nonhealing CVUs (CEAP clinical class C6) that included 67% with primary chronic venous disease (CVD), 26% with post-thrombotic ulcers, and 7% with mixed ulcer origin [18].
  • Aurora-A kinase is considered a potential cancer susceptibility gene that encodes a centrosome-associated, cell cycle-regulated serine/threonine kinase [19].
 

Regulatory relationships of BLOC1S2

 

Other interactions of BLOC1S2

 

Analytical, diagnostic and therapeutic context of BLOC1S2

References

  1. FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33). Guasch, G., Mack, G.J., Popovici, C., Dastugue, N., Birnbaum, D., Rattner, J.B., Pébusque, M.J. Blood (2000) [Pubmed]
  2. Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Wang, X., Zhou, Y.X., Qiao, W., Tominaga, Y., Ouchi, M., Ouchi, T., Deng, C.X. Oncogene (2006) [Pubmed]
  3. Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines. Katsetos, C.D., Reddy, G., Dráberová, E., Smejkalová, B., Del Valle, L., Ashraf, Q., Tadevosyan, A., Yelin, K., Maraziotis, T., Mishra, O.P., Mörk, S., Legido, A., Nissanov, J., Baas, P.W., de Chadarévian, J.P., Dráber, P. J. Neuropathol. Exp. Neurol. (2006) [Pubmed]
  4. Comparison of new continuous measurements of ambulatory venous pressure (AVP) with conventional tiptoe exercise ambulatory AVP in relation to the CEAP clinical classification of chronic venous disease. Eifell, R.K., Ashour, H.Y., Lees, T.A. J. Vasc. Surg. (2006) [Pubmed]
  5. Results of the national pilot screening program for venous disease by the american venous forum. McLafferty, R.B., Lohr, J.M., Caprini, J.A., Passman, M.A., Padberg, F.T., Rooke, T.W., Bush, R.L., Zakaria, A.A., Flinn, W.R., Eklof, B.G., Dalsing, M.C., Markwell, S.J., Wakefield, T.W. J. Vasc. Surg. (2007) [Pubmed]
  6. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Krämer, A., Mailand, N., Lukas, C., Syljuåsen, R.G., Wilkinson, C.J., Nigg, E.A., Bartek, J., Lukas, J. Nat. Cell Biol. (2004) [Pubmed]
  7. Characterization of Ceap-11 and Ceap-16, two novel splicing-variant-proteins, associated with centrosome, microtubule aggregation and cell proliferation. Wang, Z., Wei, H., Yu, Y., Sun, J., Yang, Y., Xing, G., Wu, S., Zhou, Y., Zhu, Y., Zhang, C., Zhou, T., Zhao, X., Sun, Q., He, F. J. Mol. Biol. (2004) [Pubmed]
  8. The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules. Khodjakov, A., Rieder, C.L. J. Cell Biol. (1999) [Pubmed]
  9. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. Bischoff, J.R., Anderson, L., Zhu, Y., Mossie, K., Ng, L., Souza, B., Schryver, B., Flanagan, P., Clairvoyant, F., Ginther, C., Chan, C.S., Novotny, M., Slamon, D.J., Plowman, G.D. EMBO J. (1998) [Pubmed]
  10. Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules. Barros, T.P., Kinoshita, K., Hyman, A.A., Raff, J.W. J. Cell Biol. (2005) [Pubmed]
  11. Identification and localization of a novel, cytoskeletal, centrosome-associated protein in PtK2 cells. Baron, A.T., Salisbury, J.L. J. Cell Biol. (1988) [Pubmed]
  12. Centrosome-associated RNA in surf clam oocytes. Alliegro, M.C., Alliegro, M.A., Palazzo, R.E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  13. Characterization of Su48, a centrosome protein essential for cell division. Wang, Q., Du, X., Meinkoth, J., Hirohashi, Y., Zhang, H., Liu, Q., Richter, M., Greene, M.I. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  14. Abrogation of the retinoblastoma tumor suppressor checkpoint during keratinocyte immortalization is not sufficient for induction of centrosome-mediated genomic instability. Piboonniyom, S.O., Duensing, S., Swilling, N.W., Hasskarl, J., Hinds, P.W., Münger, K. Cancer Res. (2003) [Pubmed]
  15. Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles. Paoletti, A., Moudjou, M., Paintrand, M., Salisbury, J.L., Bornens, M. J. Cell. Sci. (1996) [Pubmed]
  16. Effects of taxol on human neutrophils. Roberts, R.L., Nath, J., Friedman, M.M., Gallin, J.I. J. Immunol. (1982) [Pubmed]
  17. The centrosome-associated Aurora/Ipl-like kinase family. Goepfert, T.M., Brinkley, B.R. Curr. Top. Dev. Biol. (2000) [Pubmed]
  18. Prognostic role of factor XIII gene variants in nonhealing venous leg ulcers. Tognazzo, S., Gemmati, D., Palazzo, A., Catozzi, L., Carandina, S., Legnaro, A., Tacconi, G., Scapoli, G.L., Zamboni, P. J. Vasc. Surg. (2006) [Pubmed]
  19. Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. Chen, J., Sen, S., Amos, C.I., Wei, C., Jones, J.S., Lynch, P., Frazier, M.L. Mol. Carcinog. (2007) [Pubmed]
  20. Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest. Arachchige Don, A.S., Dallapiazza, R.F., Bennin, D.A., Brake, T., Cowan, C.E., Horne, M.C. Exp. Cell Res. (2006) [Pubmed]
  21. Oncostatin M-stimulated apical plasma membrane biogenesis requires p27(Kip1)-regulated cell cycle dynamics. Van IJzendoorn, S.C., Théard, D., Van Der Wouden, J.M., Visser, W., Wojtal, K.A., Hoekstra, D. Mol. Biol. Cell (2004) [Pubmed]
  22. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. Ou, Y.Y., Mack, G.J., Zhang, M., Rattner, J.B. J. Cell. Sci. (2002) [Pubmed]
  23. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. Cuif, M.H., Possmayer, F., Zander, H., Bordes, N., Jollivet, F., Couedel-Courteille, A., Janoueix-Lerosey, I., Langsley, G., Bornens, M., Goud, B. EMBO J. (1999) [Pubmed]
  24. Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Bergoglio, V., Pillaire, M.J., Lacroix-Triki, M., Raynaud-Messina, B., Canitrot, Y., Bieth, A., Garès, M., Wright, M., Delsol, G., Loeb, L.A., Cazaux, C., Hoffmann, J.S. Cancer Res. (2002) [Pubmed]
  25. Mechanisms of spindle-pole organization are influenced by kinetochore activity in Mammalian cells. Manning, A.L., Compton, D.A. Curr. Biol. (2007) [Pubmed]
  26. Molecular requirements for kinetochore-associated microtubule formation in mammalian cells. Tulu, U.S., Fagerstrom, C., Ferenz, N.P., Wadsworth, P. Curr. Biol. (2006) [Pubmed]
  27. Effect of external valvuloplasty of the deep vein in the treatment of chronic venous insufficiency of the lower extremity. Wang, S.M., Hu, Z.J., Li, S.Q., Huang, X.L., Ye, C.S. J. Vasc. Surg. (2006) [Pubmed]
  28. Nek2A kinase regulates the localization of numatrin to centrosome in mitosis. Yao, J., Fu, C., Ding, X., Guo, Z., Zenreski, A., Chen, Y., Ahmed, K., Liao, J., Dou, Z., Yao, X. FEBS Lett. (2004) [Pubmed]
  29. Postembedding alpha-tubulin immunolabelling of isolated centrosomes. Gowen, B.E., Buendia, B., Karsenti, E., Fuller, S.D. Histochem. J. (1995) [Pubmed]
 
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